Shin-Fu Chen
JobTitle： Assistant Professor
CurrentJob： Chang Chung University
E-mail： sfchen@cgu.edu.tw
Phone： +886-3-211-8800 ext. 3199
Education： Ph.D., National Taiwan University
Expertise： Biochemistry, Molecular Biology, Structural Biology, and Macromolecular Complexes
Chang Chung University Academic Capacity Ensemble
https://pure.lib.cgu.edu.tw/en/persons/shin-fu-chen/Research Directions and Laboratory Features
- Our lab focuses on transcriptional regulation in eukaryotes, with a particular emphasis on the structural and functional studies of the Mediator complex and its kinase module. We further investigate their interactions with diverse transcription factors and cellular signaling molecules to uncover the molecular mechanisms underlying transcriptional regulation. We utilize a variety of experimental techniques, including single-particle cryo-electron microscopy (cryo-EM), X-ray crystallography, biochemical and biophysical approaches, and AI-assisted computational modeling, to investigate the structures and regulatory mechanisms of these complexes.
Our research encompasses:
- Protein–nucleic acid interactions
- Protein conformational dynamics
- Assembly mechanisms of macromolecular complexes
- Structural and functional impacts of disease-related mutations
- Protein–small molecule interactions
Grounded in structural biology, we aim to elucidate disease-related mechanisms and, through interdisciplinary and clinical collaborations, bridge fundamental discoveries with cancer therapy, opening new avenues for precision medicine.
AWARD
-
First Prize, Poster Session, Postgraduate Group
CPRIT BIG-TCR Annual Retreat, 2024 -
First Place, Poster Presentation
Department of Biochemistry and Molecular Biology Annual Retreat, McGovern Medical School, 2024 -
CPRIT BIG-TCR Postdoctoral Research Fellowship
Funded by the Cancer Prevention and Research Institute of Texas, 2023–2024 -
Third Place, Oral Presentation
Department of Biochemistry and Molecular Biology Annual Retreat, McGovern Medical School, 2023 -
First Place, Oral Presentation
Department of Biochemistry and Molecular Biology Annual Retreat, McGovern Medical School, 2022 -
Distinguished Thesis Prize
15th Tien-Te Lee Biomedical Award, 2019
第十五屆永信李天德醫藥科技獎 — 傑出論文獎 -
Outstanding Award for Postgraduate Students’ Publications
National Taiwan University College of Medicine, 2019
國立臺灣大學醫學院研究生優秀著作獎 — 107 學年度博士班傑出著作獎 -
First Place, Student Oral Presentation in Biological Science
The 23rd NSRRC Users’ Meeting and Workshops, National Synchrotron Radiation Research Center, 2017
Publication
4. Lindsey Barron, Subash Khadka, Robert Schenken, Long He, John Blenis, Julian Blagg, Shin-Fu Chen, Kuang-Lei Tsai, Thomas G Boyer. (2021) Identification and characterization of the mediator kinase-dependent myometrial stem cell phosphoproteome. F&S Science. Volume 2, Issue 4, Pages 383-395
5. Feng Xiong†, Ruoyu Wang†, Joo-Hyung Lee, Shenglan Li, Shin-Fu Chen, Zian Liao, Lana Al Hasani, Phuoc T Nguyen, Xiaoyu Zhu, Joanna Krakowiak, Dung-Fang Lee, Leng Han, Kuang-Lei Tsai, Ying Liu, Wenbo Li. (2021) RNA m6A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability. Cell Res. 31(8):861-885. (†co first author)
6. Yi-Chuan Li†, Ti-Chun Chao†, Hee Jong Kim, Timothy Cholko, Shin-Fu Chen, Guojie Li, Laura Snyder, Kotaro Nakanishi, Chia-en Chang, Kenji Murakami, Benjamin A Garcia, Thomas G Boyer#, Kuang-Lei Tsai#. (2021) Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module. Sci Adv. 7(3):eabd4484.