Current Appointment: Director/Distinguished Professor, Research Center for Emerging Viral Infections, Chang Gung University, Taiwan
Education： Ph.D. Graduate Program in Molecular Biology and Biochemistry, Rutgers University, the State University of New Jersey, New Brunswick, New Jersey, U.S.A.
Specialties：Clinical Virology、Biotechnology、Molecular Biology、Biochemistry
TEL：(03) 211-8800 ext. 5497
Mail：srshih@mail.cgu.edu.tw

Shin-Ru Shih got her bachelors degree in Medical Biotechnology and masters degree in Biochemistry from National Taiwan University, and her Ph.D. in Biochemistry and Molecular Biology from Rutgers University, USA. Since 1996, she established a molecular virology laboratory in Chang Gung University and the Research Center for Emerging Viral Infections in 2008. Her team has been studying many aspects of emerging RNA viruses, including identification of unknown viruses using novel biotechnologies, mechanisms of pathogenesis and development of antiviral compounds. Their study of EV71 began in 1998, when a large EV71 outbreak occurred in Taiwan. Their participation contributed significantly to the laboratory diagnosis of EV71. They subsequently focused on viral-host interactions, in which molecular targets for drug discovery were identified, and series of compounds were developed that inhibit EV71 replication. Dr. Shih was awarded the National Medal for Outstanding Youth in 2004 for contributing to EV71 research in Taiwan.
Influenza virus is another focus of her team. This research includes molecular surveillance of Taiwanese strains, mechanistic study of host-restriction of influenza virus infection, pathogenesis study and development of anti-flu agents. 

Current Appointments:
Director/Distinguished Professor, Research Center for Emerging Viral Infections, Chang Gung University
Faculty in the Department of Medical Biotechnology and Laboratory Science & Graduate Program of Biomedical Sciences, Chang Gung University
Medical Director, Clinical Virology Laboratory, Department of Clinical Pathology, Chang Gung Memorial Hospital

Education:
1991-1995       Ph.D. Graduate Program in Molecular Biology and Biochemistry, Rutgers University, the State University of New Jersey, New Brunswick, New Jersey, U.S.A.
1989-1991       M.S. Department of Biochemistry, National Taiwan University, Taipei, Taiwan, R.O.C.
1984-1988       B.S. Department of Medical Technology, National Taiwan University, Medical Technologist Licensure, Taiwan.

Research and Professional Positions/Appointments:
1995-1996       Postdoctoral Fellow       Department of Microbiology, Center for Advanced Biotechnology and Medicine of New Jersey, New Brunswick, NJ, USA
1996-1997       Lecturer                       School of Medical Technology, Chang Gung University (CGU), Tao-Yuan, Taiwan
1997-2004       Associate Professor       School of Medical Technology & Institute of Basic Medicine, CGU
2003-2009       Chair                           Department of Medical Biotechnology and Laboratory Science, CGU
2004-2012       Adjunct Investigator      Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes
2012-2014       Chair                           Study section of Microbiology and Medical Biotechnology, Ministry of Science and Technology
2004-present    Professor                     Department of Medical Biotechnology and Laboratory Science/Graduate Program of Biomedical Science, CGU
1999-present    Medical Director           Clinical Virology LaboratoryChang Gung Memorial Hospital
2003-present    Member                      Committee of Preparedness for Influenza Pandemic, Department of Health (gov.), Taiwan
2006-present    Chair                          Clinical Virology, Professional & Technical Examinations (National) for Medical Technologists, Ministry of Examination, Taiwan
2009-present    Director                       Research Center for Emerging Viral Infections 
2004-2012        Adjunct Investigator    Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes
2006-2020       Chair                           Clinical Virology, Professional & Technical Examinations (National) for Medical Technologists, Ministry of Examination, Taiwan
2012-2014       Chair                           Study section of Microbiology and MedicalBiotechnology, Ministry of Science and Technology
1999-present   Principal Investigator  Viral Surveillance Program Reference Laboratory for CDC 
2003-2020       Member                      Committee of Preparedness for Influenza Pandemic, Department of Health (gov.), Taiwan
2018-2020       President                    Taiwan Society for Virology
2020-2021       Member                      Committee of Preparedness for Pandemic, Department of Health (gov.), Taiwan

Teaching Experience:
Certificate of Competence – competent in teaching courses of expertise in English

Courses:
Clinical Virology
Advanced Virology
Molecular Biology
Advanced Biotechnology
Scientific Methods
Supervisory experience
Graduated Ph.D. students: 24 persons

Dr. Shih-Cheng Chang (Research Director, Department of Clinical Pathology, CGMH); Dr. Jing-Yi Lin (Assistant Professor, Department of Laboratory Science and Medical Biotechnology, National Taiwan University); Dr. Tzu-Chun-Chen (Research Associate, Stanford University); Dr. Chiayn Chiang (Project Leader, Taigen Biotech); Dr. Kuo-Feng Weng (Research Associate, Stanford University), Dr. Chi-Jene Chen (Assistant Professor, China Medical University); Dr. Sherry Hsieh (Chief Researcher, Medigen Vaccinology Corp.); Dr. Peng-Nien Huang (Assistant Professor/Professional Manager for Industrial Cooperation, CGU); Dr. Lilien Chen (FDA), Dr. CH Huang (Assistant Professor, National Defense Medical University); Dr. Chee-Keng Mok (Researcher at National University of Singapore); Dr. Yen-Chin Lui (Assistant Investigator, RCEVI); Arul Balaji Velu (Chief Scientific Officer, Hive Serene PVT.LTD); Dr. Yi-Hsiang Chen, (Chief Manager, Far East Bio-Tec Co. Ltd.) Dr. Yu-An Kung (Assistant Investigator, RCEVI); Dr. Chuan-Tien Hung (postdoc, Icahn School of Medicine at Mount Sinai); Dr. Cheng-Kai-Chang (postdoc, National Taiwan University). ; Dr. Po-Tien Hsieh ( UBI Vaccinology Corp.); Dr. Chung-Guei Huang (Director, Department of Clinical Pathology, CGMH); Dr. Sheng-Yu Huang (postdoc, RCEVI)

Trainee in postdoctorial program:
Dr. Mei-Feng Chen (Assistant Researcher, CGMH); Dr. Shu-Ming Kuo (Associate Professor, Pasteur Institute, Shanghai); Dr. Kuo-Ming Lee (AssistantProfessor, RCEVI, CGU); Dr. Yen-Ron Fu (National Taiwan University); Dr. Hsin-Ping Chiu (Icahn School of Medicine at Mount Sinai); Dr. Ami Shih (China Medical University); Pei-Yu Wang; Tsu-Haou Shi
Graduated Master students: 42 persons
Current postdoctoral fellows: 4 persons (Dr. Pei-Yu Wang;  Dr. Tsu-Haou Shi, Dr. Gui-Ching Hsiung, Dr. Sebastian Reining)
Current Ph.D students: 6 persons
Current Master students: 4 persons

Students’ Awards:
Kuo-Feng Weng: Outstanding Master Thesis Award (CGU), 2004
Chiayn Chiang: Outstanding Ph.D. Thesis Award (NSC), 2008
Peng-Nien Huang, Outstanding Master Thesis Award (the first place, CGU), 2008
Chia-Ron Tsai, Creative Research Award for student (NSC, 2011)
Chee-Keng Mok, Outstanding Ph. D. Thesis Award (CGU), 2011
Li-Ting Lin, Outstanding Master Thesis Award (the first place, CGU), 2011
Peng-Nien Huang, Outstanding Ph.D. Thesis Award (CGU), 2112
Shiou-Wen Chen, Outstanding Master Thesis Award (CGU), 2012
Chun-Tien Hung, Outstanding Thesis Award (CGU), 2013
Chien-Shun Lee, Outstanding master Thesis Award (CGU), 2013
Po-Ting Hsieh, Oral Presentation Award (The second place, The 12th Chinese Biomedical Science Symposium, Shanghai), 2013
Hsin-Ju Wang, Outstanding Master Thesis Award (the first place, CGU), 2014
Nien-Shin Shih, Presentation Award, (Taiwanese Association of Medical Technology), 2015
Shen-Yu Huang, Presentation Award (Taiwanese Society for Virology Annual Meeting), 2017
Chuan-Tien Hung, Outstanding Paper Award (Taiwanese Society for Microbiology), 2017.
Sheng-Yu Huang, Outstanding Research Award for Ph.D. students (the second place, CGU, 2018)
Chuan-Tien Hung, Outstanding Paper Award (Taiwanese Society for Microbiology), 2017.
Sheng-Yu Huang, Outstanding Research Award for Ph.D. students (the second place, CGU, 2018)
Yu-An Kung, Outstanding Paper Award (Taiwanese Society for Microbiology), 2018.
Jeff KT Liu, Outstanding Master Thesis Award (the second place, CGU), 2019.
Rei-Ping Wang, Outstanding Master Thesis Award (CGU), 2019.
Wade Lin, Outstanding Master Thesis Award (CGU), 2020.
Princy KY Yu, Outstanding Master Thesis Award (CGU), 2021.
Hsin-Yi Wang, Outstanding Master Thesis Award (CGU), 2022.
Hang-Pin Chang, Outstanding Young Person Award (CGU), 2023.

Interviews by TV and press
Science 101 (Da-Ai TV, Taiwan)
Influenza viruses (National TV, Taiwan)
Cross reactivity of SARS and HTLV (Bloomberg News)
Enteroviruses (National TV, Taiwan)
Human infection by avian influenza virus (Vardfokus -www.vardfokus.se, Sweden)
Control of COVID-19 in Taiwan (Discovery)

Grant Supports (currently):
Source:  National Science Council, Taiwan
Title: Role of ACSL-4 in picornavirus infection
Role: Principle Investigator
Period: 8/1/2021- 7/31/2024

Source: Ministry of Education 
Title: Center for Excellence (Research Center for Emerging Viral Infections)
Role: Principle Investigator 
Period: 1/1/2018- 12/31/2027

Source: NIH, USA (integrated project)
Title: United World Antiviral Research Network (UWARN) 
Role: Principle Investigator (for a component project)
Period: 5/1/2020- 4/30/2025

Editor of Journal
1997-2006        Assistant Editor, Journal of Biomedicine and Laboratory Science    (Taipei)
2003-2006        Executive Guest Editor, Current Pharmaceutical Design (Netherlands)
2005-present    Member of the Editorial Board, Biomedical Journal (Taiwan)  
2012-2014        Section Editor (positive stranded RNA viruses), Virology Journal (UK)
2009-present    Member of the Editorial Board, Microbes and Infection (Paris, France)
2018-2020        Associate Editor, PLoS Pathogens (USA)
2020-2023        Section Editor for COVID-19, PLoS Pathogens (USA)

Expert Reviewer
PLoS Pathogens, Journal of Virology; Virology; Journal Medical Virology; Journal of Virological Methods; Journal of General Virology; Archives of Virology
FEBS Letter; Nucleic Acids Research; Cellular Microbiology; Journal of Biomedical Sciences
Lancet, Emerging Infectious Diseases; Journal of Infectious Diseases; International Journal of Infectious Diseases; Journal of Clinical Microbiology
Antiviral Research; Microbial Pathogenesis
Nature Communications, PNAS ; Trends in Microbiology; mBio; Science, Nature

Societies and Memberships:
American Society for Microbiology
American Society of Virology
International Society for Antiviral Research
Society of Medical Technologists in Taiwan
Society of Microbiology in Taiwan

International Speeches (invited):
Sequence Analysis of the Entire Genome of Enterovirus 71 Isolated from the 1998 Outbreak in Taiwan. In 3rd International Symposium on Viral and Chlamydial Infections. 1999.
Molecular virology study of enterovirus 71 isolated in an epidemic in Chinese Taipei, 1998. In APEC Enteroviral Watch Program for Children Symposium – Enterovirus 71 Epidemic in Asia Pacific Area. 2000.
The 3C protease activity of enterovirus 71 induced human neural cell apoptosis. In the 9th SCBA International Symposium. 2001.
Development of anti-EV71 drugs. The Symposium of Enterovirus 71 in Taiwan, Past and Future. Taoyuan, Taiwan. 2003.
Pyridyl Imidazolidinones: a novel capsid-binder against enterovirus 71. Bio/Pharm 2003 – Opportunities across the Asia Pacific. King of Prussia, Pennsylvania, USA. 2003.
Epidemiology of influenza in Taiwan. International Conference on Influenza and the Resurgence of Severe Acute Respiratory Syndrome (SARS). Taipei, Taiwan. 2003.
Surveillance and genetic analysis of human influenza viruses in Taiwan. In APEC Conference on Avian Influenza, Taichung, 2005.
Sequence variations of influenza A viruses. First Taiwan-Netherlands Workshop on Pathogenomics. Amsterdam, Netherlands, 2006.
Plasticity of influenza viral genome. Pasteur/NHRI/CDC symposium on re-emerging virus infections. Tainan. 2006;
Plasticity of influenza viral genome. Pasteur-Asia Virology Course, Hong Kong, 2007. .
Consensus and diversity of influenza viral RNP genes and their functions. Orchid Meeting, Pasteur Institute, Paris, France, 2008.
Research on emerging RNA Viruses. Pasteur Institute, Shanghai, China, 2008.
Molecular diagnosis of influenza viruses. The 15th Chinese Laboratory Medicine Conference, Hong Kong, 2009.
Convener of the session “Positive Strand RNA Viruses and Host Proteins Interactions”. Annual Meeting of “American Society for Virology”, Vancouver, Canada, 2009
Genomic signatures of pandemic (H1N1) 2009 influenza virus. Workshop Taiwan-Japan “Host-Pathogen Interaction”. Japan Science and Technology Institute. Kyoto, Japan, 2009.
Dissecting viral host interactions by an emerging virus - enterovirus 71. 2011 International Symposium on Infectious Diseases, Tainan, 2011.
Convener of the session “Picornaviruses”. Annual Meeting of “American Society for Virology”, Madison, Wisconsin, USA, 2012.
Molecular targets for anti-enterovirus 71 drug development. Keynote speaker, The 16th Annual Meeting of Society for Neurovirology, Japan, 2012.  
Viral host interplay in enterovirus 71 infection. Keynote speaker, Frontiers in Biomedical Research, the University of Hong Kong, HK, 2012.
Viral host interaction in EV71 – infected cells. The 12th Chinese Biomedical Science Symposium, Shanghai, 2013.
Plasticity of influenza virus. The 31st World Congress Biomedical Laboratory Science, Taipei.2015
Host factors involved in enterovirus 71 infection, Keystone Symposia (positive strand RNA viruses), Texas, USA, 2016
Novel machinery for regulation of enterovirus viral translation. HFMD international conference, Singapore, 2016.
New emerging enterovirus infections, Europic, Geneva, Switzerland, 2016. (Keynote speaker)
Epidemiology and viral host interactions, enterovirus workshop, NIAID, NIH, USA, 2017
Enterovirus A-71: from basic to clinical research, Seminar in CIIID, University of Washington, Seattle, USA. 
Genome translation and replication of EV-A71, Europic, Netherlands, 2018 (Keynote speaker)
Virus and host – basic and clinical researches for COVID-19, Bio Incheon Global Conference, Korea (invited on-line speaker), 2020.
Developments of diagnostic methods, vaccine and antivirals for COVID-19 in Taiwan. Cold Spring Harbor Asia COVID19/SARS CoV2 Rapid Research Reports (invited on line speaker), 2020.
Novel serology test for COVID-19. NonaMedicine, EEE international meeting (invited on line speaker), 2021.
Molecular virology study of SARS-CoV-2 and related clinical applications. 14th International Congress of Cell Biology & 9th Asian Pacific Organization for Cell Biology, 2022.
RNA viruses unleashed – bridging science and heal. Chan Zukerburg Biohub, SF, USA, 2024. 

Scientific Function
Scientific committee for APCMV-2015, Board in Taiwanese Society of Virology, Biosecurity Officer for CGMH BSL3 Laboratory
President, Taiwanese Society for Virology, 2019 – 2021

Awards
The Best Poster Presentation Award. The 3rd Chinese Laboratory Medicine Conference, Hong Kong. 1997.
Outstanding Research Award. Chang Gung University, Taiwan. 2002.
The National Medal for Outstanding Young People, (93年中華民國青年獎章), Taiwan, 2004.
Outstanding Teaching Award. Chang Gung University, Taiwan. 2011.
Most Valuable Article Award, Journal of Formosan Medical Association, (臺灣醫學會雜誌年度最有價值論文獎) Taiwan, 2011.
國科會特殊優秀人才獎勵 (2010-2014)；教育部優良教授獎勵(2011-2104).
Outstanding Research Award. Chang Gung University, Taiwan. 2012.
Outstanding Research Award. National Science Council (Ministry of Science and Technology), (101國科會傑出研究獎) Taiwan. 2013.
Research Grant Award, Human Frontier Science Program (HFSP). International, 2015-2018.
Outstanding Award for Industrial Cooperation, Chang Gung University. (技合獎) 2016.
Wang Ming-Ning Award, from Wang Ming-Ning Memorial Foundation.『第26屆王民寧獎』『學術研究成果對醫藥科技發展、國民健康和國家社會傑出貢獻獎』【基礎醫學類】得獎人, 2016.
Outstanding Research Award. Ministry of Science and Technology, (105科技部傑出研究獎) Taiwan. 2017.
Futuristic Breakthrough Technology Award (Inventor), 2018-Ministry of Science and Technology, Taiwan, 2018
Outstanding Award for Industrial Cooperation, Chang Gung University. (技合獎) 2020.
Outstanding Research Award, Chang Gung University, 2020.
Taipei Biotech Award (Technology Transfer Special Mention Award -Silver) (台北生技獎)
Outstanding Award for Technology Transfer. Ministry of Science and Technology, (110科技部傑出技轉貢獻獎) Taiwan. 2021.
World’s Top 2% Scientists 2020; 2021;2022, 2023 (published by Stanford University Based on Scopus database); 史丹佛大學發布「全球前2%頂尖科學家」
杜聰明博士演講獎
Outstanding Awards for Research and Technology Transfer. Chang Gung University, 2022.
The Best Scientist, Research.com, 2023

Publications:
https://pure.lib.cgu.edu.tw/en/persons/shin-ru-shih-2/publications/