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長庚大學
:::
黃玄贏醫師

黃玄贏

職稱： 教授

現職： 高雄長庚紀念醫院解剖病理科教授級主治醫師

信箱： hyhuang@cgmh.org.tw

電話： 07-731-7123

學歷： 高雄醫學院醫學系

專長領域： 骨骼與軟組織病理、分子病理、頭頸部腫瘤病理

經歷


2023~迄今 高雄長庚紀念醫院解剖病理科主任

2012~迄今 長庚大學醫學院病理學兼任教授

2019~迄今 Editorial board member of Human Pathology (SCI)

2013-迄今 台灣病理學會常務理事

2004~迄今 衛服部國民健康局骨骼軟組織病理諮詢委員兼召集人

1999~迄今 高雄長庚紀念醫院解剖病理科主治醫師

2010~2017 高雄長庚紀念醫院解剖病理科主任

2011-2023 台灣病理學會理事

2011、2013及2021 Co-convener of the 7th (Taipei, Taiwan), 8th (Busan,Korea), and 12th (Okayama, Japan) Asia-Pacific IAP congress, bone and soft tissue session

2012~2020 台灣病理學會分子病理教育委員

2008~2009、2011~2012、2014及2017 國家科學及技術委員會解剖、法醫、病理組複審委員

2009~2011 長庚大學醫學院病理學專任副教授

2006~2009 長庚大學醫學院病理學專任助理教授

2004~2006 樹人醫護管理專科學校病理學兼任助理教授

2001~2003 美國Sloan-Kettering癌症中心骨骼與軟組織病理學研究員

1995~1999 高雄長庚紀念醫院病理科住院醫師

1995~1995 高雄醫學大學附設醫院腦神經內科住院醫師


學會與認證

台灣病理學會

United States and Candian Academy of Pathology

International Society of Bone and Soft tissue Pathology

研究計畫(近三年)

國科會 :

1.硫胺素轉運蛋白SLC19A2做為多形性黏液樣肉瘤腫瘤抑制因子的分子機制和臨床病理學意涵：在抗血管生成、抗侵襲性、粒線體相關代謝重組的新穎功能角色(111-2320-B-182A-006-MY3, 2022/8/1~ 2025/7/31)

長庚研究計畫:

1.整合轉錄組表達、全基因組外顯子定序和甲基組學分析以探索世界衛生組織定義風險等級以外之孤立性纖維瘤的預後決定分子(CMRPG8P0821)

2.分析擬似RB1缺陷性纖維脂肪瘤但具有PLAG1/HMGA2融合基因之間質腫瘤的轉錄組學和甲基組學特徵：釐清屬於一特定的新穎腫瘤實體或既有腫瘤類型之遺傳變體(CMRPG8N0891)

3.各類週邊神經鞘腫瘤之SH3PXD2A::HTRA1基因融合的綜合分子特性描述：其在獨特神經鞘瘤亞群之診斷價值、臨床病理學相關性以及潛在生物學和致病作用意涵(CMRPG8M1201, CMRPG8M1202)

廠商贊助研究計畫 :

1.結合Pan-TRK免疫組織化學篩選與融合激？限定之RNA測序用以檢測紡錘形間質腫瘤、炎性肌纖維母細胞腫瘤、和膽管癌中NTRK或功能類似的激融合(XPRPG8P0041)

2.Pan-TRK陽性胃腸道間質瘤各種潛在致病畸變之研究：強調腸道和再發病例(XPRPG8N0131, XPRPG8N0132)

論文發表(近五年)

1. Kao YC, Lee JC, Zhang L, Sung YS, Swanson D, Hsieh TH, Liu YR, Agaram NP, Huang HY, Dickson BC, Antonescu CR. Recurrent YAP1 and KMT2A Gene Rearrangements in a Subset of MUC4-negative Sclerosing Epithelioid Fibrosarcoma. Am J Surg Pathol. 2020 Mar;44(3):368-377. (SCI, 2023 IF:4.5, rank, 19/290=6.6 % in Surgery)

2. Kao YC, Lee JC, Huang HY*. What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification. Virchows Arch. 2020 Jan;476(1):121-134. Review. (corresponding author) (SCI, 2023 IF:3.4, rank, 22/88=25.0% in Pathology)

3. Liau JY, Tsai JH, Lan J, Chen CC, Wang YH, Lee JC, Huang HY.* GNA11 joins GNAQ and GNA14 as a recurrently mutated gene in anastomosing hemangioma. Virchows Arch. Virchows Archiv 2020, 476:475–481. (SCI co-corresponding author) (SCI, 2023 IF:3.4, rank, 22/88=25.0% in Pathology)

4. Chang Chien YC , Mokánszki A, Huang HY, Raimundo GS Jr, Chien CC, Beke L, Mónus A, Méhes G. First Glance of molecular profile of atypical cellular angiofibroma/cellular angiofibroma with sarcomatous transformation by next generation sequencing. Diagnostics. 2020 Jan 9;10(1):35. (SCI, 2023 IF:3.0, rank, 58/325=17.8% in Medicine,General& Internal)

5. Lee JC, Huang HY.* Soft Tissue Special Issue: Giant Cell-Rich Lesions of the Head and Neck Region Head Neck Pathol. 2020 Mar;14(1):97-108 (SCI, 2023 IF:3.2, rank, 25/88=28.4 % in Pathology)

6. Xu B, Chang K, Folpe AL, Kao YC, Wey SL, Huang HY, Gill AJ, Rooper L, Bishop JA, Dickson BC, Lee JC, Antonescu CR. Head and Neck Mesenchymal Neoplasms With GLI1 Gene Alterations: A Pathologic Entity With Distinct Histologic Features and Potential for Distant Metastasis. Am J Surg Pathol. 2020 Jun;44(6):729-737. (SCI, 2023 IF:4.5, rank, 19/290=6.6 % in Surgery)

7. Ho CH, Lin HC, Chou CC, Huang HY. Sinonasal angioleiomyoma Ear Nose Throat J. 2019 Jul 4:145561319858913. doi: 10.1177/0145561319858913 (SCI, 2023 IF:1.0, rank, 35/43=81.4 % in Otorhinolaryngology)

8.  Huang YH, Lu YC, Huang HY, Chen CC. Fine-needle aspiration cytology of melanotic schwannoma in the submandibular gland. Diagn Cytopathol. 2020 Jan;49(1):142-145. (SCI, 2023 IF:1.0, rank, 26/30=86.7 % in Medical Laboratory Technology)

9.  Wang JC, Li WS*, Kao YC, Lee JC, Lee PH, Huang SC, Tsai JW, Chen CC, Chang CD, Yu SC, Huang HY*. Clinicopathologic and molecular characterization of USP6-rearranged soft tissue neoplasms: The evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity. Histopathology. 2021 April:78.676-689  (SCI 2023 IF: 3.9, rank: 17/88 =19.3 % in Pathology, co-corresponding author)

10. Li CF, Chan TC, Wang CI, Fang FM, Lin PC, Yu SC, Huang HY*. RSF1 requires CEBP/ β and hSNF2H to promote IL-1β-mediated angiogenesis: The clinical and therapeutic relevance of RSF1 overexpression and amplification in myxofibrosarcomas. Angiogenesis. 2021 Aug;24(3):533-548 (Corresponding author, SCI 2023 IF=9.2, rank: 3/96=3.1% in Peripheral Vascular Disease)

11. Kung HC, Hsiao YT, Huang HY, Hsiao CC. Infant malignant ectomesenchymoma masquerading as inguinal hernia in two patients. Pediatr Neonatol. 021 May;62(3):324-326. (SCI 2023 IF=2.3, rank: 53/186=28.5% in Pediatrics)

12. Lee JC*, Li WS, Kao YC, Chung YC, Huang HY*. Toward a unifying entity that encompasses most, but perhaps not all, inflammatory leiomyosarcomas and histiocyte-rich rhabdomyoblastic tumors. Mod Pathol 2021 Jul;34(7):1434-1438 (co-corresponding author)(SCI,2023 IF: 7.1, rank: 5/88=5.7 % in Pathology)

13. Chen CF, Peng SL, Lee CC, Lui CC, Huang HY, Chien CY. Dynamic contrast-enhanced magnetic resonance imaging in correlation with tongue cancer stages. Acta Radiol. 2021 Dec;62(12):1618-1624.  (SCI,2023 IF: 1.1, rank: 153/204 =75.0 % in Radiology,Nuclear Medicine &Medical Imaging)

14. Mathai AM, Alexander J, Huang HY, Li CF, Jeng YM, Fung KM, Harris WP, Swanson PE, Truong C, Yeh MM. S100P as a marker for poor survival and advanced stage in gallbladder carcinoma. Ann Diagn Pathol. 2021 Mar 22;52:151736. doi: 10.1016/j.anndiagpath.2021.151736. (SCI,2023 IF: 1.5, rank: 56/88 =63.6% in Pathology)

15.Chen PC, Huang HY, Chung MY, Pan CC. Ossifying low grade endometrial stromal sarcoma with PHF1-BRD8 fusion. Cancer Genet. 2021 Apr 22;256-257:81-85. (SCI,2023 IF: 1.4, rank: 152/191=79.6% in Genetics & Heredity) 

16. Kao YC, PH Lee, Wu CL, Yu SC, Huang HY*. Superficial ALK-rearranged myxoid spindle cell neoplasm with a novel FMR1-ALK fusion gene. Mod Pathol. 2021 Mar;35(3):438-441 (corresponding author,2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology).

17. Chen CH, Chang KC, Chuang CH, Huang HY*. The emerging PRRX1-NCOA fibroblastic neoplasm: A combined reappraisal of published tumors and two new cases. Virchows Arch. 2021 (corresponding author, SCI, 2023 IF:3.4, rank, 22/88=25.0% in Pathology)

18. Liang CW, Fang PW, Huang HY, Lo CM. Deep convolutional neural networks detect tumor genotype from pathological tissue images in gastrointestinal stromal tumors. Cancers 2021 in press (SCI, 2023 IF:4.5, rank, 78/322=24.2% in oncology).

19. Lee PH, Kao YC, Hsieh TH, Liao JB, Li CF, Lee JC, Chang YM, Chang CD, Huang SC, Chen TZ, Liu TT, Yu SC, Huang HY*. Myoepithelial and oral intracranial myxoid mesenchymal tumor-like neoplasms as diagnostic considerations of the ever-expanding extracranial myxocollagenous tumors harboring FET-CREB fusions. Pathol Res Pract 2021, Nov in press (corresponding author, (SCI, 2023 IF:2.9, rank, 28/88=31.8% in Pathology)

19. Lee PH#, Huang SC#, Wu PS^, Tai HC^, Lee CH, Lee JC, Kao YC, Tsai JW, Hsieh TH, Li CF, Li WS, Liu TT, Su YL, Yu SC, Huang HY*. Molecular characterization of dermatofibrosarcoma protuberans: the clinicopathologic significance of uncommon fusion gene rearrangements and their diagnostic importance in the exclusively subcutaneous and circumscribed lesions. Am J Surg Pathol. 2022 Jul 1;46(7):942-955. (Corresponding author,( SCI, 2023 IF:4.5, rank, 19/290=6.6 % in Surgery)

20. Tsai JW§, Lee JC§, Hsieh TH, Huang SC, Lee PH, Liu TT, Kao YC, Chang CD, Weng TF, Li CF, Lin JC, Liang CW, Su YL, Chang IYF, Wang YT, Chang NY, Yu SC, Wang JC, Huang HY*. Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements. Mod Pathol. 2022 July; (35):911–921. (Corresponding author,SCI,2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology).

21. Kuo CT, Kao YC, Huang HY, Hsiao CH, Lee JC. Malignant gastrointestinal neuroectodermal tumor in head and neck: two challenging cases with diverse morphology and different considerations for differential diagnosis. Virchows Arch. 2022 Jan 18. doi: 10.1007/s00428-022-03274-y. (SCI, 2023 IF:3.4, rank, 22/88=25.0% in Pathology)

22. Kao YC, Kuo CT, Kuo PY, Huang HY, Lu TP, Hsieh TH, Fletcher CDM, Lee JC. Pulmonary "Inflammatory Leiomyosarcomas" Are Indolent Tumors With Diploid Genomes and No Convincing Rhabdomyoblastic Differentiation. Am J Surg Pathol. 2022 Mar 1;46(3):424-433. (Corresponding author, SCI, 2023 IF:4.5, rank, 19/290=6.6 % in Surgery)

23. Liu TT, Chien-Feng Li CF, Tan KT, Jan YH, Lee PH, Huang CH, Yu SC, Tsao CF, Wang JC, Huang HY* Characterization of aberrations in DNA damage repair pathways in gastrointestinal stromal tumors: the clinicopathologic relevance of γH2AX and 53BP1 in correlation with heterozygous deletions of CHEK2, BRCA2, and RB1.Cancers (Basel). 2022 Mar 31;14(7):1787. doi: 10.3390/cancers14071787. (SCI, 2023 IF:4.5, rank, 78/222=24.2% in oncology).

24. Chen CC, Wu PH, Chuang SC, Huang HY. Sublingual clear cell carcinoma with liver metastasis: A case report and literature review. Kaohsiung J Med Sci. 2022 Jun 15. doi: 10.1002/kjm2.12567. (SCI, 2023 IF:2.7, rank, 95/189=50.3% in Medicine, General & Internal).

25. Chen KH, Huang HY, Chen TC, Liu YJ, Lin IC, Ng KF, Chuang HC, Huang SC. A clinicopathological reappraisal of orbital vascular malformations and distinctive GJA4 mutation in cavernous venous malformations. Hum Pathol. 2022 Oct 6:S0046-8177(22)00241-6. doi: 10.1016/j.humpath.2022.10.002. (SCI, 2023 IF:2.7, rank, 31/88=35.2% in Pathology).

26. Chang Chien YC, Madarász K, Csoma SL, Mótyán JA, Huang HY, Méhes G, Mokánszki A. Molecular Identification and In Silico Protein Analysis of a Novel BCOR-CLGN Gene Fusion in Intrathoracic BCOR-Rearranged Sarcoma. Cancers (Basel). 2023 Jan 31;15(3):898. (SCI, 2023 IF:4.5, rank, 78/322=24.2% in Oncology).

27. Huang SC, Chang IYF, Chang CJ, Liu H, Chen KH, Liu TT, Hsieh TY, Chuang HC, Chien-Cheng Chen, Lin IC, Ng KF, Huang HY*, Chen TC*. Association between hepatic angiosarcoma and end-stage renal disease: nationwide population-based evidence and enriched mutational signature of aristolochic acid exposure. J Pathol. 2023 June;260(2):165–176 (co-corresponding authors, SCI in press, (SCI, 2023 IF:5.6, rank, 8/88=9.1% in Pathology).

28. Kao YC, Yoshida A, Hsieh TH, Nord KH, Saba KH, Ichikawa H, Tsai JW, Huang HY, Chih-Hsueh Chen P, Fletcher CDM, Lee JC. Identification of COL1A1/2 Mutations and Fusions With Noncoding RNA Genes in Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion). Mod Pathol. 2023 Feb;36(2):100011 (SCI, 2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology).

29. Huang SC, Lee JC, Hsu YC, Tsai JW, Kao YC, Hsieh TH, Chang YM, Chang KC, Wu PS, Chen PCH, Chen CH, Chang CD, Lee PH, Tai HC, Liu TT, Wen MC, Li WS, Yu SC, Wang JC, Huang HY*. Extraskeletal myxoid chondrosarcomas: the uncommon clinicopathologic manifestations and significance of TAF15::NR4A3 fusion in 58 molecularly confirmed cases. Mod Pathol. 2023 Jul;36(7):100161. (Corresponding author, SCI, 2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology).

30. Li CF, Chan TC, Fang FM, Yu SC, Huang HY.* PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry. Int J Biol Sci. 2023 Jul 31;19(12):3920-3936. (Corresponding author, SCI, 2023 IF:8.2, rank: 31/313 =9.9 % in
Biochemistry & Molecular Biology).

31. Lee JC, Hsieh TH, Kao YC, Tsai CF, Huang HY, Shih CY, Song HL, Oda Y, Chen PC, Pan CC, Sittampalam K, Petersson F, Konishi E, Chiu WY, Chen CF, Carpenter TO, Lu TP, Chang CD, Huang SC, Folpe AL. Klotho overexpression is frequently associated with upstream rearrangements in fusion-negative phosphaturic mesenchymal tumors of bone and sinonasal tract. Mod Pathol. 2023 Sep 22:100336. doi:10.1016/j.modpat.2023.100336.( SCI, 2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology.)

32. Koshyk O, Dehner CA, van den Hout MFCM, Vanden Bempt I, Sciot R, Huang HY, Agaimy A, Din NU, Klubíčková N, Mosaieby E, Skálová A, Michalová K, Schöffski P, Oliveira AM, Halling KC, Gupta S, Gross JM, Nin JWM, Michal M, Folpe AL, Kosemehmetoglu K, Torres-Mora J, Michal M. EWSR1::POU2AF3(COLCA2) Sarcoma: An aggressive, polyphenotypic sarcoma with a head and neck predilection. Mod Pathol. 2023 Sep 22:100337. doi: 10.1016/j.modpat.2023.100337. (SCI, 2023 IF:7.1, rank: 5/88 =5.7 % in Pathology.)

33. Wang SH, Huang HY, Medeiros LJ, Chang KC. ALK-positive histiocytosis of external auditory canal in a 3-year-old boy. Am J Hematol. 2023 Oct 26. doi: 10.1002/ajh.27143. Online ahead of print. (SCI, 2023 IF: 10.1, rank: 8/97 =8.2 % in Hematology.)

34. Huang HY, Lo CM, Lu HI, Chang JP. Huge ancient schwannoma causing acute respiratory failure: a case report. J Cardiothorac Surg. 2024 Mar 15;19(1):131. (SCI, 2023 IF: 1.5, rank: 153/290 =52.8 % in Surgery.) 

35. Lee JC#, Lee PH#, Li SC^,, Liao KC^, Chang YM, Chen HC, Kao YC, Wu PS, Huang SC, Tsai JW, Hu CF, Li CH, Liu TT, Yu SC, Wang JC, Huang HY*. Systematic characterization of the clinical and pathological features of schwannomas harboring SH3PXD2A::HTRA1 fusion. Mod Pathol. 2024 Mar;37(3):100427. (Corresponding author, (SCI, 2023 IF: 7.1, rank: 5/88 =5.7 % in Pathology;) #, co-first authors, ^, equal contribution).

36. Lee PH, Huang SC, Lee JC, Li SC, JTsai JW, Chang YM, Kao YC, Wen-Lang Fan WL, Chang CD, Chen HC, Li CH, Hu CF, Liu TT, Wu PS, Nam MH, Yu SC, Wang JC, Huang HY*. In-frame insertions of SOX10 are highly enriched and characterize a distinct transcriptomic profile in gastrointestinal schwannomas. J Pathol. 2025 March. (corresponding authors, SCI in press, (SCI, 2023 IF:5.6, rank, 8/88=9.1% in Pathology).

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