Guang-Huar Young
JobTitle： Assistant Professor
CurrentJob： Assistant Professor
E-mail： D000019047@cgu.edu.tw
Phone： 03-2118800#3812
Education： Ph. D. Institute of Microbiology and Biochemistry, Biochemistry Division, National Taiwan University, Taipei, Taiwan.
Expertise： New Drug Evaluation and Development in early-stage, Biotech Intellectual Property, Proteomics, Biochemistry, Enzyme Chemistry, Nephrology.
Professional Experience
2023/08-Present Department of Biomedical Sciences, Chang Gung University
Assistant Professor.
2018/08-2023/07 Department of Translational Medicine, Energenesis-Biomedical Co. Ltd.
Director.
2021/10-Present Master & PhD Program in Biotechnology Industry, Chang Gung University
Assistant Professor (Adjunct).
2014/08-2018/07 Department of Scientific Research, Energenesis-Biomedical Co. Ltd.
Chief Scientific Officer.
2013/10-2014/10 MediaTek-National Taiwan University Advanced Research Center, Taipei, Taiwan
Technical Consultant.
2009/08-2014/07 Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Postdoctoral fellow.
2007/02-2009/07 Institute of Molecular Biology, Academia Sinica, Nankang, Taipei
Postdoctoral fellow.
2005/07-2006/09 The Ministry of National Defense, Miaoli County Reserve Command, Taiwan
Compulsory Military Service: Second Lieutenant, Chemical Officer.Awards
1. 第19屆台塑企業應用技術研討會(2024) 健康醫療與生物科技領域 學校組 優勝
2. The 80th American Diabetes Association (2020). ADA2020 Virtual Highlights.3. The Internal Stroke Conference 2018. Moderated Poster Presentation.
4. The 1st International Congress of Chinese/ Nephrologist (ICCN2015) Highlighted Poster for the Best Poster Award.
5. The 50th European Renal Association—European Dialysis and Transplantation Association (2013) Best Abstracts presented by Young Authors.Patent
USE OF ADENINE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING DIABETIC ULCER (No. I792983)Lab & Research Interest
Since Taiwan entered into high-aged society, the public health expenditure on renal disease is remaining obstinately high. The issue for prevention of renal disease becomes one of top public health challenges in our society.
The nephron composed a renal corpuscle and a renal tubule, as the functional unit of the kidney, in charge of metabolites re-absorption and urine production. In adults, the nephron exhibits a limited capacity for regeneration and differentiation, thereby the glomerular filtration rate in elderly is decline year by year. Furthermore, a growing literature provides evidence that kidney suffering injury accelerates the progression of chronic and irreversible kidney disease.
To contribute the good health and wellbeing for lives, our lab is dedicated to the study of translational medicine in kidney injury and develop the methods for early prediction and drug therapy, from the bench to the bedside.
Currently, the topics of our studies as follows:
1. Developing the methods of early prediction and drug treatment after kidney injury.
2. Slowing the progression of diabetic kidney disease by modulating purine salvage pathway.
Publications
2.
, , , , , , SH Lin, YH Lin, LG Wei, Tom J Liu, , , , , , , , , , , , , , , , EClinicalMedicine. 2022 Jul 10;51:101497. ENERGI-F703 gel, as a new topical treatment for diabe
4. GH Young, JT Lin, YF Cheng, CF Ho, QY Kuok, RC Hsu, WR Liao, CC Chen, and HM Chen. FASEB J. 2021 Mar; 35(3): e21296. Modulation of adenine phosphoribosyltransferase-mediated salvage pathway to accelerate diabetic wound healing.
5. HM Chang, KY Peng, CK Chan , CY Sun , YY Chen , HM Chang, CL Huang , PC Liu , PY Chen , KC Wang, WJ Wang , CC Wu, YF Lin, TS Lai , TM Huang , GH Young, SL Lin, Marlies Ostermann, TS Chu, Jeff S Chueh , VC Wu. Cell Death & Disease. 2021 Apr 17;12(5):409. FGF23 ameliorates ischemia-reperfusion induced acute kidney injury via modulation of endothelial progenitor cells: targeting SDF-1/CXCR4 signaling.
6. GH Young, SC Tang, VC Wu, KC Wang, JY Nong, PY Huang, CJ Hu, HY Chiou, JS Jeng, CY Hsu. J Cereb Blood Flow Metab. 2020 Jun; 40(6):1316-1327. The functional role of hemojuvelin in acute ischemic stroke.
7. TTa Wu, CC Chen, JT Lin, GH Young, HC Wang, HM Chen. Biosci Biotechnol Biochem. 2019 Dec; 83(12):2220-2229. The anti-inflammatory function of adenine occurs through AMPK activation and its downstream transcriptional regulation in THP-1 cells.
8. WC Shen, CJ Liang, TM Huang, CW Liu, SH Wang, GH Young, JS Tsai, YC Tseng, YS Peng, VC Wu, YL Chen. Archives of Toxicology. 2016 (90) 2779–2792. Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway.
9. GH Young, JT Lin, YF Cheng, CF Huang, CY Chao, JY Nong, PK Chen and HM Chen, Journal of Proteomics 2015 Apr 29;120:204-14. Identification of Adenine modulating AMPK activation in NIH/3T3 cells by Proteomic Approach.
10. YF Cheng*, GH Young*, JT Lin, HH Jang, CC Chen, JY Nong, PK Chen, CY Kuo, SH Kao, YJ Liang, HM Chen. PLoS One. 2015 Nov 6;10(11):e0142283. Activation of AMP-activated protein kinase by adenine alleviates TNF-alpha-induced inflammation in human umbilical vein endothelial cells.
11. YF Cheng, GH Young, TM Chiu, JT Lin, PR Huang, CY Kuo, YJ Liang, PK Chen, SF Chen, CY Cheng, HM Chen. Experimental Dermatology. 2016 Feb; 25(2):162-4. doi: 10.1111/exd.12881. Adenine supplement delays senescence in cultured human follicle dermal papilla cells.
12. GH Young, TM Huang, CH Wu ,CF Lai, CC Hou, KY Peng, CJ Liang, SL Lin, SC Chang, PR Tsai, KD Wu, VC Wu*, WJ Ko*, the NSARF group. Antioxidants & Redox Signaling.2014 Mar 10;20 (8):1181-94. Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor.
13. CY Sun, GH Young, YT Hsieh, YH Chen, MS Wu, JH Lee, CC Lee. Journal of the American Society of Nephrology. 2015 Feb;26(2):281-90. Protein-bound uremic toxins induce tissue remodeling by targeting epidermal growth factor receptor.
14. CF Lai, SL Lin, WC Chiang, YM Chen, VC Wu, GH Young, WJ Ko, ML Kuo, TJ Tsai, and KD Wu. The American Journal of Physiology-Renal Physiology. 2014 Jun 11. pii: ajprenal.00670.2013. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury.
15. CJ Liang, WC Shen, FB Chang, VC Wu, SH Wang, GH Young, JS Tsai, YC Tseng, YS Peng, YL Chen. Cell Transplantation. 2015;24(7):1363-77. Endothelial progenitor cells derived from Wharton's jelly of human umbilical cord attenuate ischemic acute kidney injury by increasing vascularization and decreasing apoptosis, inflammation, and fibrosis.
16. VC Wu, CK Wu, YC Chang, GH Young, SC Chen, WS Yang, CY Chen, WJ Wang, CY Lin, YH Lin, SL Lin, SC Chueh, KD Wu,TAIPAI study group. Journal of Hypertension 2013 July 31(7):1396-1405. Association of the variations in the HSD3[beta] gene with primary aldosteronism.
17. VC Wu*, GH Young*, PH Huang, SC Lo, KC Wang, CY Sun, CJ Liang, TM Huang, JHan Chen, FC Chang, YL Chen, YS Kuo, JB Chen, JW Chen, YM Chen, WJ Ko, KD Wu. Angiogenesis, 2013 Jul;16(3):609-24. In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin.
18. WC Shen, CJ Liang, VC Wu, SH Wang, GH Young, IR Lai, CL Chien, SM Wang, KD Wu, and YL Chen. Stem Cells and Development. 2013 May 1;22(9):1408-18. Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression.
19. CC Shiao, WJ Ko, VC Wu, TM Huang, CF Lai, YF Lin, CT Chao, TS Chu, HB Tsai, PC Wu, GH Young, TW Kao, JW Huang, YM Chen, SL Lin, MS Wu, PR Tsai, KD Wu, MJ Wang. PLoS One 2012, Aug 7(8):e42952. U-Curve Association between Timing of Renal Replacement Therapy Initiation and In-Hospital Mortality in Postoperative Acute Kidney Injury.
20. GH Young and VC Wu (2012, Apr). Kidney International 2012 Apr;81(7):611-2. KLOTHO methylation is linked to uremic toxins and chronic kidney disease.
21. YC Lin, HM Chen, IM Chou, AN Chen, CP Chen, GH Young, CT Lin, CH Cheng, SC Chang, RH Juang (2012, Apr). PLoS One 2012, 7:e35336. Plastidial Starch Phosphorylase in Sweet Potato Roots Is Proteolytically Modified by Protein-Protein Interaction with the 20S Proteasome.
22. VC Wu, CF Lai, CC Shiao, YF Lin, PC Wu, CT Chao, FC Hu, TM Huang, YC Yeh, IJ Tsai, TW Kao, YY Han, WC Wu, CC Hou, GH Young, WJ Ko, TJ Tsai, KD Wu. PLoS One 2012 Mar 7:e30836. Effect of Diuretic Use on 30-Day Postdialysis Mortality in Critically Ill Patients Receiving Acute Dialysis.
23. VC Wu, TM Huang, PC Wu, WJ Wang, CT Chao, SY Yang, CC Shiao, FC Hu, CF Lai, YF Lin, YY Han, YS Chen, RB Hsu, GH Young, SS Wang, PR Tsai, YM Chen, TT Chao, WJ Ko, KD Wu, the NSARF Group. PLoS One 2012 Jan 7:e27687. Preoperative Proteinuria Is Associated with Long-Term Progression to Chronic Dialysis and Mortality after Coronary Artery Bypass Grafting Surgery.
24. VC Wu, TM Huang, CF Lai, CC Shiao, YF Lin, TS Chu, PC Wu, CT Chao, JY Wang, TW Kao, GH Young, PR Tsai, HB Tsai, CL Wang, MS Wu, WC Chiang, IJ Tsai, FC Hu, SL Lin, YM Chen, TJ Tsai, WJ Ko and KD Wu, on behalf of the NSARF Group Kidney International 2011 Aug 7:e27687. Acute-on-chronic kidney injury at hospital discharge is associated with long-term dialysis and mortality.
25. YH Chou, TM Huang, VC Wu, CY Wang, CC Shiao, CF Lai, HB Tsai, CT Chao, GH Young, WJ Wang, TW Kao, SL Lin, YY Han, Anne Chou, TH Lin, YW Yang, YM Chen, PR Tsai, YF Lin, JW Huang, WC Chiang, NK Chou, WJ Ko, KD Wu, TJ Tsai1 and the NSARF Study Group. Critical Care 2011 Jun 15: R134. Impact of timing of renal replacement therapy initiation on outcome of septic acute kidney injury.
26. TM Huang*, VC Wu*, GH Young, YF Lin, CC Shiao, PC Wu, WY Li, HY Yu, FC Hu, JW Lin, YS Chen, YH Lin, SS Wang, RB Hsu, FC Chang, NK Chou, TS Chu, YC Yeh, PR Tsai, JW Huang, SL Lin, YM Chen, WJ Ko and KD Wu. Journal of the American Society of Nephrology 2010 Nov 22(1):156-63. Preoperative Proteinuria Predicts Adverse Renal Outcomes after Coronary Artery Bypass Grafting.
27. CC Shiao, VC Wu, WY Li, YF Lin, FC Hu, GH Young. CC Kuo, TW Kao, DM Huang, YM Chen, PR Tsai, SL Lin, NK Chou, TH Lin, YC Yeh, CH Wang, Anne Chou, WJ Ko, KD Wu. Critical Care 2009 Oct 13(5): R171. Late initiation of renal replacement therapy is associated with worse outcomes in acute kidney injury after major abdominal surgery.
28. GH Young, HM Chen, CT Lin, KC Tseng, JS Wu, RH Juang. Planta 2006 Feb 223:468-478. Site-specific phosphorylation of L-form starch phosphorylase by the protein kinase activity from sweet potato roots.