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Department of Biomedical Sciences (Master's Program in Clinical Trials Assessment)

Department of Biomedical Sciences (Master's Program in Clinical Trials Assessment)
:::
洪

Li-Man Hung

JobTitle： Professor

CurrentJob： Professor

E-mail： lisahung@mail.cgu.edu.tw

Phone： lisahung@mail.cgu.edu.tw

Education： Ph.D. College of Medicine, National Taiwan University, Taiwan

Expertise： Heart physiology

Lab & Research Interest

    A close link between heart failure (HF) and diabetes mellitus (DM) has long been recognized in the clinical setting. However, the challenge of understanding the association between DM and HF is complicated by the multifaceted interplay between various hemodynamic, metabolic, and other physiological factors that ultimately impact on cardiovascular system. Moreover, the multifarious web of interconnected processes begins with the onset of DM and the cumulative effects on the cardiac abnormalities may not become clinically apparent for several years or more. Thus, in terms of the actual impact of DM on the HF, we are still only seeing the tip of the proverbial iceberg today. Currently, increasing attention has been paid to insulin resistance as a distinct cause of cardiac dysfunction and heart failure in diabetic patients. Insulin resistance and abnormal glucose metabolism are very common in heart failure patients, being identified in 43% of these patients, and such abnormalities are associated with decreased cardiac function. In addition, evidence has emerged that myocardial insulin resistance is central to altered metabolism in the failing heart and may play a crucial role in the development of HF. Hence, my current research interest is to investigate how the metabolic changes affected cardiac maladaptive remodeling and consequently development of cardiomyopathy. Specifically, we have manipulated several insulin resistant and inflammatory animal models to illustrate the correlation and interaction of the multiple risk factors which affect metabolism and cardiovascular functions during diabetes process.

Publications

(Selected Publications)

1.          Ma H, Zhang J, Zhou L, Wen S, Tang HY, Jiang B, Zhang F, Suleman M, Sun D, Chen A, Zhao W, Lin F, Tsau MT, Shih LM, Xie C, Li X, Lin D, Hung LM* (correspondence), Cheng ML, Li Q. c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3. Cell Rep. 24;30(12)：4235-4249, 2020.

2.          Chan YH, Chang GJ, Lai YJ, Chen WJ, Chang SH, Hung LM, Kuo CT, Yeh YH. Atrial fibrillation and its arrhythmogenesis associated with insulin resistance. Cardiovasc Diabetol.  26;18(1):125, 2019.

3.          Huang JP, Hsu SC, Li DE, Chen KH, Kuo CY, Hung LM* (correspondence). Resveratrol Mitigates High-Fat Diet-Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and Sirt1/ER Pathway. Journal of Cardiovascular Pharmacology. 72(5):231-241, 2018.

4.          Chu WK, Hung LM, Hou CW, Chen JK. Heterogeneous ribonucleoprotein F regulates YAP expression via a G-tract in 3'UTR. Biochim Biophys Acta Gene Regul Mech. S1874-9399 (18)30174-3, 2018.

5.          Chung YH, Lu KY, Chiu SC, Lo CJ, Hung LM, Huang JP, Cheng ML, Wang CH, Tsai CK, Lin YC, Chang SH, Lin G. Early Imaging Biomarker of Myocardial Glucose Adaptations in High-Fat-Diet-Induced Insulin Resistance Model by Using 18F-FDG PET and [U-13C]glucose Nuclear Magnetic Resonance Tracer. Contrast Media Mol Imaging.  Jul 12;2018

6.          Huang JP, Hsu SC, Meir YJ, Hsieh PS, Chang CC, Chen KH, Chen JK, Hung LM* (correspondence). Role of dysfunctional adipocytes in cholesterol-induced nonobese metabolic syndrome. J Mol Endocrinol. 60(4)：307-321, 2018.

7.          Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung LM, Ruan J, Mak TW, Li Q, Han J. 2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter. Cell Rep. 30;19(9)：1846-1857, 2017.

8.          Jiang B, Zhang J, Xia J, Zhao W, Wu Y, Shi M, Luo L, Zhou H, Chen A, Ma H, Zhao Q, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, He Y, Li X, Hung LM, Mak TW, Li Q. IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation. Cell Rep. 11;19(2)：389-400, 2017.

9.          Huang JP, Cheng ML, Hung CY, Wang CH, Hsieh PS, Shiao MS, Chen JK, Li DE, Hung LM*(correspondence). Docosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high-fat and high-fructose diets. Journal of Diabetes.  9(10)：936-946, 2017.

10.      Jiung-Pang Huang, Mei-Ling Cheng, Chao-HungWang, Ming-Shi Shiao, Jan-Kan Chen & Hung LM*(correspondence). High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy. International Journal of Cardiology. 215 (2016): 65–76, 2016.

11.      Chih-Chun Chang, Keng-Yang Lin, Kang-Yu Peng, Yuan-Ji Day & Hung LM* (correspondence). Resveratrol exerts anti-obesity in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells. Endocrine Journal. 63 (2): 169-78, 2016.