Yi-Ting Chen
JobTitle： Professor
CurrentJob： Professor
E-mail： ytchen@mail.cgu.edu.tw
Phone： 03-2118800#3558
Education： Ph.D. in Chemistry, National Tsing Hua University, Taiwan
Expertise： Biological Mass Spectrometry, Translational Proteomics, Metabolomics, Urologic Oncology
Website： https://reurl.cc/Kl23y9
Professional Experience
2024.8- Associate Director, Molecular Medicine Research Center, Chang Gung University
2023.8- Professor, Department of Biomedical Sciences, Chang Gung University.
2018-2023 Associate professor, Department of Biomedical Sciences, Chang Gung University.
2013-2018 Assistant professor, Department of Biomedical Sciences, Chang Gung University.
2007-2013 Associate research fellow, Chang Gung University
2002-2007 Research scientist, Industrial Technology Research Institute, Taiwan.
2001 Research assistant, Department of chemistry, University of Alberta, Canada.
Awards
TSMS Young Scholar Award, Taiwan Society for Mass Spectrometry, 2017.
Young Scholar Award, LCY Education Foundation, 2018, Taiwan.
Awards for students
1. Hsiao-Wei Chen, Master’s student from the Graduate Institute of Biomedical Sciences at Chang Gung University, Best Poster Award (corresponding author), 2009 TPS International Proteomics Conference and 5th AUHUPO MPI Workshop, June 19-20, 2009, Taipei, Taiwan. (Taiwan Proteomics Society Annual Meeting)
2. Hsiao-Wei Chen, Master’s student from the Graduate Institute of Biomedical Sciences at Chang Gung University, Best Poster Award (corresponding author), 2nd CGMH International Symposium on Disease Proteomics, June 6th, 2009, Taoyuan, Taiwan.
3. Hsiao-Wei Chen, Master’s student from the Graduate Institute of Biomedical Sciences at Chang Gung University, Best Poster Award, 2010 Disease Biomarker and TPS International Proteomics Conference, April 23-24, 2010, Taipei, Taiwan. (Taiwan Proteomics Society Annual Meeting)
4. Yue-Fan Lai, Master’s student from the Graduate Institute of Biomedical Sciences at Chang Gung University, Best Poster Award, 2011 Translational Medicine Conference and Taiwan Proteomics Society Annual Symposium, April 27-28, 2011, Taipei, Taiwan. (Taiwan Proteomics Society Annual Meeting)
5. Hsiao-Wei Chen, Master’s student from the Graduate Institute of Biomedical Sciences at Chang Gung University, Dissertation Award, Chinese Chemical Society, Dec. 3-4, 2011, Hsinchu, Taiwan. (Graduate Dissertation Award in Analytical Chemistry - First Prize)
6. Meng-Kai Chou, Master’s student from the Graduate Institute of Biomedical Sciences at Chang Gung University, Best Poster Award, Taiwan Proteomics Society Annual Conference & Translational and Systems Biology Symposium, Nov. 11-12, 2014, Taipei, Taiwan. (Taiwan Proteomics Society Annual Meeting)
7. Yi-Huai Tsai, Master’s student from the Graduate Institute of Biomedical Sciences at Chang Gung University, R&D Paper Award, 16th Formosa Plastics Group Applied Technology Symposium, Academic Category, June 6, 2018.
8. Wei-Hsuan Wang, Medical Student from Chang Gung University, 2020 National Science and Technology Council Research, TW
9. Hsien-Min Tang, Biomedical Sciences Student from Chang Gung University, 2020 National Science and Technology Council Research, TW
10. Wei-Hsuan Wang, Medical Student from Chang Gung University, 2021 National Science and Technology Council Research, TW
11. Hsiang-Cheng Tu, Third-year undergraduate student from the Department of Biomedical Sciences at Chang Gung University, Poster Presentation Excellence Award, 37th Joint Annual Conference of Biomedical Sciences (JACBS), The Chinese Society of Cell And Molecular Biology and 2023 Yungshin Tien-Te Lee Biomedical Foundation Poster Excellence Award. March 19, 2023
12. Wen-Chen Chen, Fourth-year undergraduate student from the Department of Biomedical Sciences at Chang Gung University, Oral Presentation Excellence Award, 28th symposium on analytical technologies, National Cheng Kung University, May 14, 2023.
13. Wen-Chen Chen, Fourth-year undergraduate student from the Department of Biomedical Sciences at Chang Gung University, First Place in the Research Short Talk Competition, 2023 Symposium on Food and Health Technology, Chang Gung University of Science and Technology, May 18, 2023.
14. Wei-Ju Tu, PhD student, Third Place in the Research Short Talk Competition, 2023 Symposium on Food and Health Technology, Chang Gung University of Science and Technology, May 18, 2023.
15. Hsiang-Cheng Tu, Third-year undergraduate student from the Department of Medical Technology at Chang Gung University, National Science and Technology Council Research, TW
16. Yi-Hsin Wu Third-year undergraduate student from the Department of Biomedical Sciences at Chang Gung University, National Science and Technology Council Research, TW
17. Hsiao-Wei Chen, Assistant from Chang Gung University Molecular Medicine Research Center, Bronze Award for Oral Presentation in the Medical Science Academic Category, 15th Memorial Symposium of Chang Gung Medical Week in Honor of the Founder Wang Yung-Ching, Oct. 21, 2023.
18. Wen-Chen Chen, graduate student in Bachelor's and Master's programs from the Graduate Institute of Biomedical Sciences at CGU, Top Award in Poster Competition and Finalist in Poster Presentation at the 2023 MOPM Multiomics and Precision Medicine Joint Symposium, Nov. 12, 2023.
19. Hsiang-Cheng Tu, Fourth-year undergraduate student from the Department of Medical Technology at CGU Top Award in Poster Competition at the 2023 MOPM Multiomics and Precision Medicine Joint Symposium, Nov. 12, 2023.
20. Yu Chang, Assistant from CGU Molecular Medicine Research Center, Top Award in the R&D Paper and Poster Competition, Academic Category, Formosa Plastics Group Applied Technology Symposium, June 24, 2024.
21. Wen-Chen Chen, graduate student in Bachelor's and Master's programs from the Graduate Institute of Biomedical Sciences at CGU, Student Travel Award, 72nd Annual Conference of the Mass Spectrometry Society of Japan (MSSJ), June 10-12, 2024, Tsukuba City, Japan.
22. Hsiang-Cheng Tu, Fourth-year undergraduate student from the Department of Medical Technology at CGU, Student Travel Award, 72nd Annual Conference of the Mass Spectrometry Society of Japan (MSSJ), June 10-12, 2024, Tsukuba City, Japan.
23. Hsiang-Cheng Tu, Fourth-year undergraduate student from the Department of Medical Technology at CGU, College Student Creation Award, The Chemistry Department of the National Science Council, 112th National Science and Technology Council Research Creation Award, July 2, 2024.
24. Wen-Hsin Mai, Medical Student from CGU, 2024 National Science and Technology Council Research, TW
Special Achievements
1. 2015.7-Present Elected Council Member, Taiwan Society for Mass Spectrometry
2. 2017.11-Present Elected Council Member, Taiwan Proteomics Society
Lab & Research Interest
The major topics of our research group are to develop methods and strategies, primarily based on mass spectrometry (MS), for the detection and quantification of biological molecules, including peptides, proteins, and metabolites. There approaches have been applied to study real-world biological systems including cells, tissues, and body fluids. Our research goals are focused on understanding the basis of molecular oncology of urological system by applying our specialties, including proteomics, metabolomics, biological mass spectrometry, and analytical biochemistry, through independent research ability and international collaboration.
Interest in
exploring human proteome has broadened the search for new biomarkers, as well
as disease etiology studies. Biomarker discovery in body fluid recently has
gained prominence, and numerous investigations have found that levels of
specific proteins increase or decrease during disease. One of the main
challenges in biomarker discovery is high biological variation between
individuals. Therefore, after the discovery phase, potential biomarkers must be
verified in a large number of samples. Accurate quantitation of proteins in
each sample is part of this verification phase. However, absolute quantitation
of numerous proteins in body fluids has not been systematically performed, and
their roles as useful “biosignatures” are unknown. This study thus focuses on
developing the SISCAP (stable isotope standards and capture by anti-peptide
antibodies, namely immuno-MRM-MS) platform to quantitate proteins and peptides
in biological specimens. Our lab is responsible for setting up the MRM-MS assay
for biomarker verification in a large number of clinical specimens. Using data
generated from various techniques of the individual patient combined with large
scale modeling of the network of cancer relevant pathways in the individual
tumor, a relevant prediction can be deduced towards an individualized therapy
for cancer.
Our current research projects include the following topics:
1. Using a Systems Approach to Discover and Assess Urological Cancer
Biomarkers.
System approaches for biomarker discovery and mechanism study of urological cancer
2. Targeted and Multiplexed Quantitation of Proteins for Verification of Biomarker Panels using Multiple-Reaction-Monitoring MS (MRM-MS) and immune MRM-MS. (Collaboration with Prof. Christoph Borchers, the Director of the University of Victoria Genome BC Proteomics Centre,
Publications
(1) “MALDI-TOF MS”，Yi-Ting Chen、Y. C. Ling, Instruments Today, 19, 60-70, 1997.
(2) Y. C. Ling, L. Lin and Y. T. Chen, ²Quantitative Analysis of Antibiotics by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry², Rapid Commun. Mass Spectrometry. 12, 317-327, 1998 (SCI).
(3) Y. T. Chen and Y. C. Ling, ²An Overview of Supercritical Fluid Extraction in Chinese Herbal Medicine：from Preparation to Analysis², Journal of Food and Drug Analysis, Special Issue on Chinese Herbal Medicines, 8, 235-247, 2000 (SCI).
(4) Y. T. Chen and Y. C. Ling, ²Detection of Water-soluble Vitamins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry using Porphyrin Matrices², J. Mass. Sepctrom. 37, 716-730, 2002 (SCI).
(5) Y. T Chen, C. Y. Tsao, J. M Li, C. Y. Tsai, S. F. Chiu, T. L. Tseng*, ² Large-scale Protein Identification of Human Urine Proteome by Multi-dimensional Liquid Chromatography and Tandem Mass Spectrometry ², Proteomics Clin. Appl. 1, 577-587, 2007 (SCI).
(6) Hui-Chu Hsieh, Yi-Ting Chen, Jen-Ming Li, Ting-Yu Chou, Ming-Fong Chang, See-Chang Huang, Tzu-Ling Tseng, Chung-Cheng Liu, and Sung-Fang Chen*, “Protein Profilings in Mouse Liver Regeneration after Partial Hepatectomy using iTRAQ Technology”. J. Proteome Res. 8, 1004-1043, 2009 (SCI).
(7) Yi-Ting Chen*, Chien-Lun Chen, Hsiao-Wei Chen, Ting Chung, Chih-Ching Wu, Chi-De Chen, Chia-Wei Hsu, Meng-Chieh Chen, Ke-Hung Tsui, Phei-Lang Chang, Yu-Sun Chang, Jau-Song Yu*, ² Discovery of Novel Bladder Cancer Biomarkers by Comparative Urine Proteomics Using iTRAQ Technology ², J. Proteome Research. 9, 5803-5815, 2010 (SCI).
(8) Shih-Yuan Chen, Yi-Ting Chen, Jey-Jau Lee, Soofin Cheng*, Tuning Pore Diameter of Platelet SBA-15 Materials for Enzyme Adsorption, J. Mater. Chem. 21, 5693-5703. 2011 (SCI).
(9) Yi-Ting Chen, Hsiao-Wei Chen, Derek Smith, Kung-Hao Liang, Ting Chung, Chien-Lun Chen, Yu-Sun Chang, Christoph Borchers,* Jau-Song Yu.* Multiplexed quantification of 63 proteins in human urine by multiple reaction monitoring-based mass spectrometry for discovery of potential bladder cancer biomarkers. J. Proteomics. 75, 3529-3545, 2012 (SCI).
(10) Yi-Ting Chen*, Fu-Shing Wang, Zhendong Li, Liang Li*, Yong-Chien Ling*. Development of a Matrix-assisted Laser Desorption Ionization Mass Spectrometric Method for Rapid Process-Monitoring of Phthalocyanine Compounds. Analytica Chimica Acta. 736, 69–77, 2012. (SCI)
(11) Chien-Lun Chen, Yue-Fan Lai,, Kun-Yi Chien, Jau-Song Yu, Hsiao-Wei Chen, Petrus Tang, Chia-Wei Hsu, Chi-De Chen, Yu-Sun Chang, Phei-Lang Chang, Yi-Ting Chen*, Comparative and Targeted Proteomic Analyses of Urinary Exosomes from Bladder Cancer and Hernia Patients. J. Proteome Research. 11, 5611−5629, 2012. (SCI)
(12) Yen-Heng Lin*, Ying-Ju Chen, Chao-Sung Lai*, Yi-Ting Chen, Chien-Lun Chen, Jau-Song Yu, and Yu-Sun Chang, A negative-pressure-driven microfluidic chip for the rapid detection of a bladder cancer biomarker in urine using bead-based enzyme-linked immunosorbent assay. Biomicrofluidics 7, 024103, 2013. (SCI)
(13) Chien-Lun Chen, Tsung-Shih, Lin, Cheng-Han, Tsai, Chih-Ching Wu, Ting Chung, Kun-Yi Chien, Maureen Wu, Yu-Sun Chang, Jau-Song Yu*, Yi-Ting Chen*, Identification of Potential Bladder Cancer Markers in Urine by Abundant-Protein Depletion Coupled with Quantitative Proteomics. J. Proteomics. 85, 28-43, 2013. (SCI)
(14) Chi-De Chen, Chih-Liang Wang, Chia-Jung Yu, Kun-Yi Chien, Yi-Ting Chen, Min-Chi Chen, Yu-Sun Chang, Chin-Ching Wu*, Jau-Song Yu*. Targeted Proteomics Pipeline Reveals Potential Biomarkers forthe Diagnosis of Metastatic Lung Cancer in Pleural Effusion. J. Proteome Research. 13(6):2818-29, 2014.
(15) Jun Peng, Yi-Ting Chen, Chien-Lun Chen and Liang Li, Development of a Universal Metabolome-Standard Method for Long-term LC-MS Metabolome Profiling and Its Application for Bladder Cancer Urine-Metabolite-Biomarker Discovery. Anal. Chem. 86(13):6540-7, 2014.
(16) Chiun-Gung Juo*, Chien-Lun Chen, Shiang-Ting Lin, Shu-Hsuan Fu, Yi-Ting Chen, Yu-Sun Chang and Jau-Song Yu. Mass accuracy improvement of ESI-RPLC-MS based urinary metabolomic analysis by post-run calibration using sodium formate cluster ions. Rapid Commun. Mass Spectrom. 28, 1813-1820, 2014.
(17) Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Shi-Liang Chen, Min-Cong Xiao, Chien-Lun Chen, Mu-Yi Hua*. A sensitive and selective magnetic graphene composite-modified polycrystalline-silicon nanowire field-effect transistor for bladder cancer diagnosis. Biosensors and Bioelectronics. 66, 198–207, 2015 . (Co-first author)
(18) Yi-Ting Chen, Li-Ping Tuan, Hsiao-Wei Chen, I-An Wei, Min-Yuan Chou, Han-Min Chen, Yu-Chang Tyan, Sung-Fang Chen*. Quantitative analysis of prostate specific antigen isoforms using immunoprecipitation and isotope dilution mass spectrometry. Anal. Chem. 2015, 87(1):545-53. (Co-first author)
(19) Chien-Lun Chen, Ting Chung, Chih-Ching Wu, Kwai-Fong Ng, Jau-Song Yu, Cheng-Han Tsai, Yu-Sun Chang, Ying Liang, Yi-Ting Chen*. Comparative tissue proteomics of microdissected specimens reveals novel biomarkers of bladder cancer. Mol. Cell Proteomics. 2015. 14(9), 2466-2478. (Co-first and corresponding author)
(20) Chih-Hsiang Chang, Chia-Hung Yang, Huang-Yu Yang, Tien-Hsing Chen, Chan-Yu Lin, Su-Wei Chang, Yi-Ting Chen, Cheng-Chieh Hung, Ji-Tseng Fang, Chih-Wei Yang, Yung-Chang Chen*. Urinary Biomarkers Improve the Diagnosis of Intrinsic Acute Kidney Injury in Coronary Care units. Medicine. 2015 Oct;94(40):e1703.
(21) Chih-Hsiang Chang, Pei-Chun Fan, Chan-Yu Lin, Chia-Hung Yang, Yi-Ting Chen, Su-Wei Chang, Huang-Yu Yang, Chang-Chyi Jenq, Cheng-Chieh Hung, Chih-Wei Yang, and Yung-Chang Chen. Elevation of Interleukin-18 Correlates with Cardiovascular, Cerebrovascular, and Peripheral Vascular Events: A Cohort Study of Hemodialysis Patients. Medicine. 2015 Oct;94(42):e1836.
(22) Cheng-Hung Lee , Kuo-Sheng Liu , Shang-Hung Chang , Wei-Jan Chen , Kuo-Chun Hung , Shih-Jung Liu* , Jong-Hwei S. Pang , Jyuhn-Huarng Juang , Chou Chung-Chuan , Po-Cheng Chang , Yi-Ting Chen , Fu-Shing Wang. Promoting Diabetic Wound Therapy Using Biodegradable rhPDGF-loaded Nanofibrous Membranes: CONSORT-Compliant Article. Medicine. 2015 Nov;94(47):e1873.
(23) Chia-Hung Yang, Chih-Hsiang Chang, Tien-Hsing Chen, Pei-Chun Fan, Su-Wei Chang, Chun-Chi Chen, Pao-Hsien Chu, Yi-Ting Chen, Huang-Yu Yang, Chih-Wei Yang, Yung-Chang Chen. Combination of Urinary Biomarkers Improve Early Detection of Acute Kidney Injury in Patients with Heart Failure. Circulation Journal, 2016, 25;80(4):1017-23.
(24) Cheng-Hung Lee, Yin-Kai Chao, Shang-Hung Chang, Wei-Jan Chen, Kuo-Chun Hung, Shih-Jung Liu,* Jyuhn-Huarng Juang, Yi-Ting Chen and Fu-Shing Wang. Nanofibrous rhPDGF-eluting PLGA–collagen hybrid scaffolds enhance healing of diabetic wounds. RSC Adv., 2016, 6, 6276–6284.
(25) Jau-Song Yu, Yi-Ting Chen, Wei-Fang Chiang, Yung-Chin Hsiao, Lichieh Julie Chu, Lai-Chu See, Chi-Sheng Wu, Hui-Tzu Tu, Hsiao-Wei Chen, Chia-Chun Chen, Wei-Chao Liao, Ya-Ting Chang, Chih-Ching Wu, Che-Yi Lin, Shyun-Yeu Liu, Shu-Ti Chiou, Shu-Li Cha, Kai-Ping Chang, Chih-Yen Chien, Chee-Jen Chang, John D. Young, Chia C. Pao, Yu-Sun Chang*, Leland H. Hartwell*, Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan, PNAS, 2016, 113, 11549–11554. (Co-first author).
(26) Yi-Ting Chen*, Hsiao-Wei Chen, Chun-Feng Wu, Lichieh Julie Chu, Wei-Fang Chiang, Chih-Ching Wu, Jau-Song Yu, Cheng-Han Tsai, Kung-Hao Liang, Yu-Sun Chang, Maureen Wu, Wei-Ting Ou Yang, Development of a multiplexed LC-MRM/MS method for evaluation of salivary proteins as oral cancer biomarkers. Mol. Cell Proteomics. 16, 799-811. 2017.
(27) Chi-hung Shao, Chien-Lun Chen, Chao-Jung Chen, Shu-Hsuan Fu, Yi-Ting Chen, Yu-Sun Chang, Jau-Song Yu, Chiun-Gung Juo*, Kun-Pin Wu*, Metabolite marker discovery for the detection of bladder cancer by comparative metabolomics. Oncotarget, 2017 Jun 13;8(24):38802-38810. 2017.
(28) Yung-Chin Hsiao, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Szu-Fan Chen, Yao-Ning Chuang, Shih-Yu Lin, Chia-Chun Wu, Ya-Ting Chang, Lichieh Julie Chu, Yi-Ting Chen, Shu-Li Chia, Chih-Yen Chien, Kai-Ping Chang,Yu-Sun Chang, and Jau-Song Yu, Development of a multiplexed assay for oral cancer candidate biomarkers using peptide immunoaffinity enrichment and targeted mass spectrometry. Mol. Cell Proteomics. 2017 Oct;16(10):1829-1849.
(29) Cheng-Han Tsai, Yi-Ting Chen*, Clinical proteomics of genitourinary cancer for the development of biomarkers. Clinics in Oncology, 2017, 2, 1326-1327.
(30) Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih-De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang* & Yu-Sun Chang*. APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. NATURE COMMUNICATIONS. 2017, 8: 465.
(31) Yung-Chin Hsiao, Lichieh Julie Chu, Yi-Ting Chen, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Ya-Ting Chang, Szu-Fan Chen, Wei-Shun Wang, Yao-Ning Chuang, Shih-Yu Lin, Chih-Yen Chien, Kai-Ping Chang, Yu-Sun Chang, and Jau-Song Yu. Variability assessment of 90 salivary proteins in intra-day and inter-day samples from healthy donors by multiple reaction monitoring-mass spectrometry. Proteomics Clinical Applications, 2018 Mar;12(2). doi: 10.1002/prca.201700039. Epub 2018 Feb 7.
(32) Cheng-Han Tsai1, Yi-Ting Chen*, Ying-Hsu Chang, Chuen Hsueh, Chung-Yi Liu, Yu-Sun Chang, Chien-Lun Chen*, Jau-Song Yu*. Systematic Verification of Bladder Cancer-Associated Tissue Protein Biomarker Candidates in Clinical Urine Specimens. Oncotarget, 2018, 9:30731-30747. (Co-first author and co-corresponding author).
(33) Cheng-Chia Lee, Chih-Hsiang Chang, Shao-Wei Chen*, Pei-Chun Fan, SuWei Chang, Yi-Ting Chen, Yu-Yun Nan, Pyng-Jing Lin, Feng-Chun Tsai. Preoperative Risk Assessment Improves Biomarker Detection for Predicting Acute Kidney Injury After Cardiac Surgery, PLOS ONE, 2018, 13 (9), e0203447.
(34) Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh, Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, and Li-Mei Pai*. Histidine-dependent protein methylation is required for compartmentalization of CTP Synthase, Cell Reports, 2018, 24, 2733–2745.
(35) Cheng-Chia Lee, Ya-Ju Hsieh, Shao-Wei Chen, Shu-Hsuan Fu, Chia-Wei Hsu, Chih-Ching Wu, Wei Han, Yunong Li, Huan Tao, Yu-Sun Chang, Jau-Song Yu, Liang Li, Chih-Hsiang Chang, Yi-Ting Chen*, Bretschneider solution-induced alterations in the urine metabolome in cardiac surgery patient. Scientific Reports, 2018, 8, Article number: 17774.
(36) Yi-Ting Chen*, Cheng-Han Tsai, Chien-Lun Chen, Jau-Song Yu, Ying-Hsu Chang*. Development of Biomarkers of Genitourinary Cancer using Mass Spectrometry-Based Clinical Proteomics, Journal of Food and Drug Analysis, 2019, 27, 2: 387-403.
(37) Yi-Ting Chen*, Hsin-Chien Huang, Ya-Ju Hsieh, Shu-Hsuan Fu, Liang Li, Chien-Lun Chen, Lichieh Julie Chu, Jau-Song Yu. Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers. Journal of Food and Drug Analysis, 2019, 27(2), 460-474.
(38) Chia-Wei Hsu, Yi-Ting Chen, Ya-Ju Hsieh, Kai-Ping Chang, Pei-Chun Hsueh, Ting-Wen Chen, Jau-Song Yu, Yu-Sun Chang, Liang Li*, Chih-Ching Wu*. Integrated analyses utilizing metabolomics and transcriptomics reveal perturbation of the polyamine pathway in oral cavity squamous cell carcinoma. Analytica Chimica Acta. 2019, 1050, 113-122. (Co-first author)
(39) Jia-Jin Chen, Pei-Chun Fan, George Kou, Su-Wei Chang, Yi-Ting Chen, Cheng-Chia Lee, Chih-Hsiang Chang*, Meta-analysis: urinary calprotectin for discrimination of intrinsic and prerenal acute kidney injury, J. Clin. Med., 2019, 8(1), E74.
(40) Pei-Chun Fan, Jason Chih-Hsiang Changa, Chia-Ni Lin,Cheng-Chia Leea, Yi-Ting Chen, Pao-Hsien Chu, George Koua, Yueh-An Lu, Chih-Wei Yang, Yung-Chang Chen*. Serum Indoxyl Sulfate Predicts Adverse Cardiovascular Events in Patients with Chronic Kidney Disease. Journal of the Formosan Medical Association, 2019, 118, 1099-1106.
(41) Hao-Wei Chu, Kai-Ping Chang, Chia-Wei Hsu, Ian Yi-Feng Chang, Hao-Ping Liu, Yi-Ting Chen, and Chih-Ching Wu, Identification of salivary biomarkers for oral cancer detection with untargeted and targeted quantitative proteomics approaches. Molecular & Cellular Proteomics. 2019, 18(9), 1796-1806.
(42) Yi-Ting Chen*, Wei-Ting Ou Yang, Horng-Heng Juang, Chien-Lun Chen*, Hsiao-Wei Chen, Ke-Hung Tsui, Ying-Hsu Chang, Cheng-Han Tsai, Chuen Hsueh, Wei-Chao Liao, Proteomic characterization of arsenic and cadmium exposure in bladder cells", Rapid Commun Mass Spectrom. 2020;34(S1):e8578.
(43) Cheng-Chia Lee, Chih-Hsiang Chang, Ya-Lien Cheng, George Kuo, Shao-Wei Chen, Yi-Jung Li, Yi-Ting Chen, Ya-Chung Tian*, Diagnostic performance of Cyclophilin A in cardiac surgery-associated acute kidney injury. J. Clin. Med. 2020, 9, 108; doi:10.3390/jcm9010108.
(44) Pei-Chun Hsueh; Kuo-An Wu; Chia-Yu Yang; Chia-Wei Hsu; Chih-Liang Wang; Chu-Mi Hung; Yi-Ting Chen; Jau-Song Yu; Chih-Ching Wu*. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Analytica Chimica Acta. 2020, 1128, 238-250.
(45) Jo-Chuan Liu, Yi-Ting Chen, Ya-Ju Hsieh, Chia-Chun Wu, Ming-Chyi Huang, Yu-Chao Hsu, Chun-Te Wu, Chih-Ken Chen, Srinivas Dash & Jau-Song Yu*. Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses. Sci. Rep. 11, 9583 (2021). https://doi.org/10.1038/s41598-021-89089-4.
(46) Jia‑You Lin, Bao‑Rong Juo, Yu‑Hsuan Yeh, Shu‑Hsuan Fu, Yi‑Ting Chen, Chien‑Lun Chen* and Kun‑Pin Wu*. Putative markers for the detection of early-stage bladder cancer selected by urine metabolomics, BMC Bioinformatics. 2021, 22, 305. https://doi.org/10.1186/s12859‑021‑04235‑z.
(47) Ming-Yu Fang, Kuan-Hsun Huang, Wei-Ju Tu, Yi-Ting Chen, Pei-Yun Pan, Wan-Chi Hsiao, Yi-Yu Ke, Lun K. Tsou, Mingzi M. Zhang*. Chemoproteomic profiling reveals cellular targets of nitro-fatty acids. Redox Biology. 46, 102126 (2021). https://doi.org/10.1016/j.redox.2021.102126.
(48) Ya-Ju Hsieh, Kun-Yi Chien, Chun-Ming Chang, Cheng-Yu Hung, Liang Li, Wei-Fan Chiang5, Cheng-Chia Lee, Chih-Hsiang Chang, Ying-Hsu Chang, Jau-Song Yu*, Yi-Ting Chen*. Development of a Method for Dansylation of Metabolites Using Organic Solvent-Compatible Buffer Systems for Amine/Phenol Submetabolome Analysis. Analytica Chimica Acta. 2022, 1189, 339218. https://doi.org/10.1016/j.aca.2021.339218
(49) Eric Yi-Hsiu Huang, Yu-Kuang Chen, Chen-Pu Ou, Yi-Ting Chen, Sung-Fang Chen, William J. Huang, Kung-Hao Liang * Oncogenic roles of Polycomb Repressive Complex 2 in bladder cancer and upper tract urothelial carcinoma. Biomedicines. 2022 Nov 14;10(11):2925. doi: 10.3390/biomedicines10112925.
(50) Yi-Ting Chen, Wan-Rou Liao, Hsueh-Ting Wang, Hsiao-Wei Chen, Sung-Fang Chen*. Targeted Protein Quantitation in Human Body Fluids by Mass Spectrometry. Mass Spectrom Rev. 2023.; 42(6):2379-2403. doi: 10.1002/mas.21788.
(51) Chien-Lun Chen, Yi-Ting Chen, Wen-Yu Liao, Yu-Sun Chang, Jau-Song Yu, and Bao-Rong Juo*, Urinary Metabolomic Analysis of Prostate Cancer by UPLC-FTMS and UPLC-Ion Trap MSn. Diagnostics. 2023, 13, 2270. https://doi.org/10.3390/diagnostics13132270
(52) Yi-Ting Chen*, Wei-Ju Tu, Zong-Han Ye, Chih-Ching Wu, Shir-Hwa Ueng, Kai-Jie Yu, Chien-Lun Chen, Pei-Hua Peng, Jau-Song Yu, Ying-Hsu Chang*, Integration of the cancer cell secretome and transcriptome reveals potential noninvasive diagnostic markers for bladder cancer. Proteomics Clin. Appl. 2024 Jan 9:e2300033. https://onlinelibrary.wiley.com/doi/10.1002/prca.202300033.
(53) Chih-Hsiang Chang, Cheng-Chia Lee, Yung-Chang Chen, Pei-Chun Fan, Pao-Hsien Chu, Lichieh Julie Chu, Jau-Song Yu, Hsiao-Wei Chen, Chih-Wei Yang, Yi-Ting Chen*. Identification of endothelial cell protein c receptor by urinary proteomics as a novel prognostic marker in non-recovery kidney injury, International Journal of Molecular Sciences, 2024, 25(5), 2783; https://doi.org/10.3390/ijms250527834.