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傅崇安

傅崇安 / Prof. Sebastian D. Fugmann

JobTitle： Professor

CurrentJob： Department of Biomedical Sciences；Fugmann lab

E-mail： sdfugmann@mail.cgu.edu.tw

Phone： 03-211-8800 #3478

Education： PhD

Expertise： Gene expression profiling of S. purpuratus coelomocytes；Immune receptor signaling in S. purpuratus； Inflammatory responses conserved in invertebrates RNA-editing leading to the divorce of a symbiotic relationship ；Geographic isolation and the evolution of immunity

Education and experience

Education
PhD Universität Ulm, Germany

Experience
2013- Department of Biomedical Sciences, Chang Gung University, Professor
2004-2013 National Insitute on Aging, PI

Research direction

Gene expression profiling of S. purpuratus coelomocytes
Immune receptor signaling in S. purpuratus
Inflammatory responses conserved in invertebrates
RNA-editing lead to the divorce of a symbiotic relationship
Geographic isolation and the evolution of immunity

Selected research

  • Chou ST, Lin TM, Yang HY, Fugmann SD. Functional characterization of the MyD88 homologs in Strongylocentrotus purpuratus. Dev Comp Immunol (in press).
  • Li YR, Lai HW, Huang HH, Chen HC, Fugmann SD, Yang SY. Trajectory mapping of the early Drosophila germline reveals controls of zygotic activation and sex differentiation. Genome Res. 2021 Apr 15:gr.271148.120. doi: 10.1101/gr.271148.120
  • Liu MC, Liao WY, Buckley KM, Yang SY,Rast JP, Fugmann SD. AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates. Nat Commun. 2018 May 16;9(1):1948. doi: 10.1038/s41467-018-04273-x.
  • Liao WY, Fugmann SD. Lectins identifydistinct populations of coelomocytes in Strongylocentrotus purpuratus. PLoS One. 2017 Nov 10;12(11):e0187987. doi: 10.1371/journal.pone.0187987. 
  • Wang XR, Ling LB, Huang HH, Lin JJ, Fugmann SD, Yang SY. Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis. Proc Biol Sci. 2017 May 1;284(1855):20170324. doi: 10.1098/rspb.2017.0324.
  • Carmona LM, Fugmann SD, Schatz DG. Collaborationof RAG2 with RAG1-like proteins during the evolution of V(D)J recombination. Genes Dev. 2016 Apr 15;30(8):909-17. doi: 10.1101/gad.278432.116. 
  • Fugmann SD. Form follows function -the three-dimensional structure of antigen receptor gene loci. Curr Opin Immunol. 2014 Apr;27:33-7. doi: 10.1016/j.coi.2014.01.011.