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郭敏玲

郭敏玲 / Prof. Ming-Ling Kuo

JobTitle： Professor

CurrentJob： Graduate Institute of Biomedical Sciences

E-mail： mingling@mail.cgu.edu.tw

Phone： 03-211-8800 #3319/3320

Education： PhD

Expertise： Allergic Diseases and their molecular mechanisms and novel therapies; Gene therapy for asthma; Development of drugs or antibodies to Mmdulate T Cells; Investigating scientific evidence for traditional Chinese medicine in treating asthma; Umbilical cord blood lymphocyte activity; Regulation of T helper cells and natural killer cells in umbilical cord blood by cytokines

Education and experience

Education
1988-1994 PhD Microbiology and Molecular Genetics, Rutgers University/Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey
1986-1988 MSc Medical Microbiology and Immunology, The Ohio State University
1981-1985 BSc Agricultural chemistry, Agricultural Products Manufacturing Division, National Taiwan University

Experience
1996-2004 Technical Director, Children’s Health Research Division, Chang Gung Children’s Hospital
1997-2002 Adjunct Associate Professor, Graduate Institute of Basic Medical Sciences/Microbiology and Immunology, Chang Gung University
1996-2002 Associate Researcher, Medical Research Center, Chang Gung Hospital
1994-1996 Postdoctoral Researcher, Hepatitis Research Center, National Taiwan University Hospital
1989-1994 Research assistant, Dept. of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey
1987-1988 Research assistant, Dept. of Medical Microbiology and Immunology, The Ohio State University
1985-1986 Full-time Assistant Professor, Department of Biochemistry, National Defense Medical Center

Honors and awards

2021-2024 Ministry of Science and Technology Innovation and Translation Research Project
2013 Excellent Teacher - Teaching Award, Chang Gung University
2012 Outstanding Scholar Award, Chinese Society of Immunology
2002-2006 Career Development Grant Award, National Health Research Institute, Taiwan
1988-1989 Excellence fellowship, Graduate School-New Brunswick, Rutgers University

Research direction

Allergic diseases, focusing on the molecular mechanisms and development of new therapies
Gene therapy for asthma
Development of regulatory T cells induced by drugs or antibodies
Scientific evidence for traditional Chinese medicine in treating asthma
Research on the activity of umbilical cord blood lymphocytes
Regulation of the replication, death, and activity of T helper cells and natural killer cells in umbilical cord blood using different cytokine combinations

Selected research

  • Chiang P-C, Chen J-C, Chen L-C, Kuo M-L*. Adeno-associated virus-mediated interleukin12 gene expression alleviates lung inflammation and type 2 T-helper-responses in ovalbumin-sensitized asthmatic mice. Hum. Gene Ther. 2022; 33: 1052-1061. (DOI:10.1089/hum.2022.034)
  • Ting N-C, Chen Y-H, Chen J-C, Huang W-C, Liou C-J, Chen L-C, Yang S-H‡, Kuo M-L‡.Perilla fruit water extract attenuates inflammatory responses and alleviates neutrophilrecruitment via MAPK/JNK-AP-1/c-Fos signaling pathway in ARDS animal model. eCAM 2022; 2022: 4444513, 12 pages. (DOI:10.1155/2022/4444513)
  • Lai Y-R, Chang Y-F, Ma J, Chiu C-H, Kuo M-L‡, Lai C-H‡. From DNA damage to cancerprogression: potential effects of cytolethal distending toxin. Front. Immunol. 2021; 2021: 12(DOI: 10.3389/fimmu.2021.760451)
  • Chen L-C, Tseng H-M, Kuo M-L, Chiu C-Y, Liao S-L, Su K-W, Tsai M-H, Hua M-C, Lai SH, Yao T-S, Yeh K-W, Wu A-H, Yu H-Y, Huang J-L, Huang S-K. Levels of 15-HETE and TXB in exhaled breadth condensates as markers for diagnosis of childhood asthma and its therapeutic outcome. Pediatr. Allergy Immunol. 2021; 32: 1673-1680 (DOI:10.1111/pai.13587.)
  • Ma J, Liu M-X, Chen L-C, Shen J-J, Kuo M-L* Ding Chuan Tang attenuates airway inflammation and eosinophil infiltration in ovalbumin-sensitized asthmatic mice. Biomed. Res. Int. 2021; 2021: 6692772, 10 pages. (DOI: 10.1155/2021/6692772)
  • Chang-Chien J, Huang J-L, Tsai H-J, Wang S-L, Kuo M-L‡. Yao T-C‡. Particulate mattercauses telomere shortening and cellular senescence in human lung epithelial cells. Ecotox Environ Safe. 2021. 222: 112484-112492. (DOI: 10.1016/j.ecoenv.2021.112484)
  • 7. Chen J-C, Chan C-C, Ting N-C, Kuo M-L*. Allergen exposure in murine neonates promoted the development of allergic lungs. Biomedicines. 2021; 9: 688-703. (DOI: 10.3390/biomedicines9060688)
  • Huang Y-A, Chen J-C, Wu C-C, Hsu C-W, Ko Albert M-S, Chen L-C, Kuo M-L*. Reducing lung ATP levels and alleviating asthmatic airway inflammation through adeno-associated viral vector-mediated CD39 expression. Biomedicines. 2021; 9: 656-669. (DOI:10.3390/biomedicines9060656)
  • Chen J-C, Ou L-S, Kuo M-L, Tseng L-Y, Chang H-L, Chen S-C, Chui C-H. Fetal macrophages exposed to Salmonella antigens elicit protective immunity against overwhelming Salmonella challenge in a murine model. Biomedicines. 2021; 9: 245-260. (DOI: 10.3390/biomedicines9030245)
  • Chen Y-W, Huang M-Z, Chen C-L, Kuo C-Y, Yang C-Y, Ni-Chiang C, Chen Y-Y, Hsieh CM, Wu H-Y, Kuo M-L, Chiu C-H, Lai C-H. PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. Part. Fibre. Toxicol. 2020; 17:37-51. (DOI: 10.1186/s12989-020-00362-2.)
  • Khan M, Huang Y-A, Kuo C-Y, Lin T, Lu C-H, Chen L-C, Kuo M-L*. Blocking pannexin1 reduces airway inflammation in a murine model of asthma. Am. J. Transl. Res. 2020; 12:4074-4083. (PMCID: PMC7407700)
  • Ma J, Chan C-C, Huang W-C, Kuo M-L*. Berberine inhibits pro-inflammatory cytokineinduced IL-6 and CCL11 production via modulation of STAT6 pathway in human bronchial epithelial cells. Int. J. Med. Sci. 2020; 17: 1464-1473. (DOI: 10.7150/ijms.45400)
  • Lu C-H, Chen C-M, Ma J, Wu C-J, Chen L-I, Kuo M-L*. DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation. Int. Immunopharmacol. 2020; 84:106542. (DOI:10.1016/j.intimp.2020.106542)
  • Lin T-C, Kuo C-C, Wu C-Y, Yeh K-W, Kuo M-L‡, Huang J-L‡. The role of 5-methoxytryptophan in pediatric-onset lupus nephritis: a retrospective cohort study. J.Microbiol. Immunol. Infect. 2020; 53: 797-802. (DOI: 10.1016/j.jmii.2018.12. 003)
  • Wu C-J, Cho S, Huang H-Y, Lu C-H, Russ J, Cruz L-O, Cunha da Cunha F-F, Chen M-C, Lin L-L, Warner L-M, Liao H-K, Utzschneider D-T, Quon S, Berner J, Camara N-O-S, Zehn D, Belmonte J-C-I, Chen L-C, Huang S-K, Kuo M-L, Lu L-F. MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation. Sci. Adv. 2019; 5: eaaw1715. (DOI: 10.1126/sciadv.aaw1715)
  • Ting N-C, Hung W-C, Chen L-C, Yang S-H, Kuo M-L*. Descurainia sophia water extract ameliorates eosinophil infiltration and airway hyperresponsiveness by reducing Th2 cytokine production in asthmatic mice. Am. J. Chin. Med. 2019; 47: 1507-1522. (DOI:10.1142/S0192415X19500770.)
  • Lin S-J, Kuo M-L, Hsiao H-S, Lee P-T, Lee W-I, Chen J-Y, Huang J-L. Cytotoxic function and cytokine production of natural killer cells and natural killer T-like cells in systemic lupus erythematosis-regulation with interleukin-15. Mediat. Inflamm. 2019; 2019: 4236562, 12 pages. (DOI:10.1155/2019/4236562)
  • Wu C-J, Tseng P-H, Chan C-C, Sara Quon, Chen L-C, Kuo M-L*. OK-432 acts as adjuvant to modulate T helper 2 inflammatory responses in a murine model of asthma. J. Immunol. Res. 2018; 2018: 1-9. (DOI: 10.1155/2018/1697276)
  • Chen J-C, Ou L-S, Chan C-C, Kuo M-L, Tseng L-Y, Chang H-L. In utero exposure to exosomal and B-cell alloantigens lessens alloreactivity of recipients’ lymphocytes rather than confers allograft tolerance. Front. Immunol. 2018. 9: 418-426. (DOI: 10.3389/fimmu.2018.00418)
  • Kuo C-Y, Huang W-C, Liou C-J, Chen L-C, Shen J-J, Kuo M-L*. Tomatidine attenuates airway hyperresponsiveness and inflammation by suppressing Th2 cytokines in a mouse model of asthma. Mediat. Inflamm. 2017; 4: 5261803. (DOI 10.1155/2017/5261803)