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沈家瑞

沈家瑞 / Prof. Chia-Rui Shen

JobTitle： Professor

CurrentJob： Department of Medical Biotechnology and Laboratory Science

E-mail： crshen@mail.cgu.edu.tw

Phone： 03-2118800 #5200

Education： PhD

Expertise： Immunotherapy; Medical laboratory science; Vaccine development; Molecular imaging

Education and experience

Education
1998 PhD Pathology and Microbiology, University of Bristol, UK
1993 BSc Medical Technology, National Cheng Kung University

Experience
2021- Professor, Molecular Clinical Immunology Center, Chang Gung University
2019- Board Member and Executive Supervisor, Taiwan AI Application Development Association
2019 Graduated from the 4th Manager Class, Northern Region, Taiwan AI Academy
2018- Professor and Department Chair, Department of Medical Biotechnology and Laboratory Science, Chang Gung University
2018- Professor and Division Head, Division of Biotechnology, Graduate Institute of Biomedical Sciences, Chang Gung University
2016- Associate Researcher, Department of Ophthalmology, Retina Division, Linkou Chang Gung Memorial Hospital
2008- Board Member, Taiwan Chitin and Chitosan Society
2013-2018 Board Member, Chinese Society of Immunology
2013 Visiting Researcher, Genomics Research Center, Academia Sinica
2010-2018 Associate Professor, Department of Medical Biotechnology and Laboratory Science, Chang Gung University
2006-2007 Visiting Scholar, Department of Radiology, Washington University in St. Louis, USA
2003- Member of the Examination and Question Review Committee for National Examinations for Physicians, Chinese Medicine Practitioners, and Medical Technologists, Ministry of Examination
2000-2010 Assistant Professor, Department of Medical Biotechnology and Laboratory Science, Chang Gung University
1998-2000 Postdoctoral Researcher, Institute of Biomedical Sciences, Academia Sinica
1993-1994 Full-time Assistant Professor, Department of Medical Technology, National Cheng Kung University

Awards and honors

2020 Outstanding Award and Honorable Mention in the “AI Smart Application New Generation Talent Cultivation Program” by the Industrial Development Bureau, Ministry of Economic Affairs
2020 Distinguished Alumnus, College of Medicine, National Cheng Kung University
2018 Research Creation Award, Ministry of Science and Technology College Student Research Project (as a supervising professor)
2017 Research Creation Award, Ministry of Science and Technology College Student Research Project (as a supervising professor)
2018 First Place in the Student Forum, Medical Laboratory Science Society (as a supervising professor, co-supervised with Rui-Lin Guo and Qiao-Ni Wen)
2015: Excellent Teacher Teaching Award, Chang Gung University

Selected research

  • Huang SE, Kuo CH, Shiao SY, Shen CR, et al. Soluble CD93 lectin-like domain sequesters HMGB1 to ameliorate inflammatory diseases. Theranostics 2023;13:4059-4078.
  • Lo SM, Hwang YS, Liu CL, Shen CN, Hong WH, Yang WC, Lee MH, Shen CR (correspondence). Inhibiting TLR7 expression in the retinal pigment epithelium suppresses experimental autoimmune uveitis. Front Immunol. 2022; 12:736261.
  •  Hsu LJ, Liu CL, Kuo ML, Shen CN, Shen CR (correspondence). An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells. Biomedicines 2021; 9(10):1323.  
  • Chen YS, Hwang CH, Liu CL, Chen HS, Wu ST, Lee MH, Shen CR (correspondence). Locally targeting the IL-17/ IL-17RA axis reduced tumor growth in a murine B16F10 melanoma model. Hum Gene Ther. 2019 Mar; 30(3):273-285.
  • Yang WC, Hwang YS, Chen YY, Liu CL, Shen CN, Hong WH, Lo SM, Shen CR (correspondence). Interleukin-4 supports the suppressive immune responses elicited by regulatory T cells. Front Immunol 2017 Nov; 8: Article 1508.
  • Shen CR, Yang WC, Chen HW. The fate of regulatory T cells: survival or apoptosis. Cell Mol Immunol 2014 Jan; 11(1):11-13. doi:10.1038/cmi.2013.49.
  • Tsai JP, Lee MH, Hsu SC, Chen MY, Liu SJ, Chang JT, Liao CT, Cheng AJ, Chong P, Shen CR (correspondence), Chen HW. CD4+ T cells disarm or delete cytotoxic T lymphocytes under IL-17-polarizing conditions. J Immunol 2012 189:1671-1679.
  • Yang CJ, Liu YK, Liu CL, Shen CN, Kuo ML, Su CC, Tseng CP, Yen TC, Shen CR (correspondence). Inhibition of acidic mammalian chitinase by RNAi suppresses OVA-sensitized allergic asthma. Hum Gene Ther 2009 Dec; 20(12): 1597- 1606.
  • Hall AM, Ward FJ, Shen CR (equal to first), et al. Deletion of the dominant autoantigen in NZB mice with autoimmune hemolytic anemia: effects on autoantibody and T-helper responses. Blood 2007 Dec 15; 110(13): 4511- 4517.
  • Shen CR, Youssef AR, Devine A, et al. Peptides containing a dominant T-cell epitope from red cell band 3 have in vivo immunomodulatory properties in NZB mice with autoimmune hemolytic anemia. Blood 2003 Nov 15; 102(10):3800-6.
  • Shen CR, Ward FJ, Devine A, et al. Characterization of the dominant autoreactive T-cell epitope in spontaneous autoimmune haemolytic anaemia of the NZB mouse. J. Autoimmun. 2002 Mar; 18(2):149-57.