Chang Gung University

Expertise： Biological mass spectrometry、Proteomics、Metabolomics、Analytical Chemistry、Urology

Research Direction

Dr. Yi-Ting Chen's research focus is on developing high-throughput technologies to detection of biomolecules, primarily based on mass spectrometry for application in translational studies of urological diseases. Dr. Chen participates in several integrated research programs and serves as an investigator in the detection of bladder, kidney, and oral cancers using proteomics, metabolomics, and systems biology approaches to understand human diseases. Our group’s research is dedicated to the development of targeted and untargeted proteomic and metabolomic platforms for disease diagnosis / prognosis. We have established several workflows for the identification of novel biosignature candidate molecules, including proteins and metabolites, for human disease. The methods are primarily based on analytical chemistry, mass spectrometry and bioinformatics to study the real world and clinical unmet needs. We have established Omics approaches to investigate the alteration of biological molecules in various biomedical specimens including blood, tissue, cell lysates and secretome, urine, saliva, and amniotic fluids, etc. The current research focus is the development of a systems biology approach to the identification and quantification of proteins/peptides and metabolites associated with the bladder cancer, oral cancer, renal diseases, and energy-metabolism during disease progression. We have established the standard workflow for targeted and precise quantification of more than two hundred of biomolecules in a LC-MS run using multiple reaction monitoring mass spectrometry (MRM-MS), which has been called the gold standard of MS-based quantitation methods. The laboratory is interested in research directed toward disease biomarker discovery using clinical human tissues, body fluids and associated cell models. The laboratory is also involved in various collaborations with chemical and biomedical researchers as well as clinical physicians (oncologists, urologists, pediatrician, and obstetrician) at the national and international levels.

Publications

(1) “MALDI-TOF MS”，Yi-Ting Chen、Y. C. Ling, Instruments Today, 19, 60-70, 1997.

(2) Y. C. Ling, L. Lin and Y. T. Chen, ²Quantitative Analysis of Antibiotics by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry², Rapid Commun. Mass Spectrometry. 12, 317-327, 1998 (SCI).

(3) Y. T. Chen and Y. C. Ling, ²An Overview of Supercritical Fluid Extraction in Chinese Herbal Medicine：from Preparation to Analysis², Journal of Food and Drug Analysis, Special Issue on Chinese Herbal Medicines, 8, 235-247, 2000 (SCI).

(4) Y. T. Chen and Y. C. Ling, ²Detection of Water-soluble Vitamins by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry using Porphyrin Matrices², J. Mass. Sepctrom. 37, 716-730, 2002 (SCI).

(5) Y. T Chen, C. Y. Tsao, J. M Li, C. Y. Tsai, S. F. Chiu, T. L. Tseng*, ² Large-scale Protein Identification of Human Urine Proteome by Multi-dimensional Liquid Chromatography and Tandem Mass Spectrometry ², Proteomics Clin. Appl. 1, 577-587, 2007 (SCI).

(6) Hui-Chu Hsieh, Yi-Ting Chen, Jen-Ming Li, Ting-Yu Chou, Ming-Fong Chang, See-Chang Huang, Tzu-Ling Tseng, Chung-Cheng Liu, and Sung-Fang Chen*, “Protein Profilings in Mouse Liver Regeneration after Partial Hepatectomy using iTRAQ Technology”. J. Proteome Res. 8, 1004-1043, 2009 (SCI).

(7) Yi-Ting Chen*, Chien-Lun Chen, Hsiao-Wei Chen, Ting Chung, Chih-Ching Wu, Chi-De Chen, Chia-Wei Hsu, Meng-Chieh Chen, Ke-Hung Tsui, Phei-Lang Chang, Yu-Sun Chang, Jau-Song Yu*, ² Discovery of Novel Bladder Cancer Biomarkers by Comparative Urine Proteomics Using iTRAQ Technology ², J. Proteome Research. 9, 5803-5815, 2010 (SCI).

(8) Shih-Yuan Chen, Yi-Ting Chen, Jey-Jau Lee, Soofin Cheng*, Tuning Pore Diameter of Platelet SBA-15 Materials for Enzyme Adsorption, J. Mater. Chem. 21, 5693-5703. 2011 (SCI).

(9) Yi-Ting Chen, Hsiao-Wei Chen, Derek Smith, Kung-Hao Liang, Ting Chung, Chien-Lun Chen, Yu-Sun Chang, Christoph Borchers,* Jau-Song Yu.* Multiplexed quantification of 63 proteins in human urine by multiple reaction monitoring-based mass spectrometry for discovery of potential bladder cancer biomarkers. J. Proteomics. 75, 3529-3545, 2012 (SCI).

(10) Yi-Ting Chen*, Fu-Shing Wang, Zhendong Li, Liang Li*, Yong-Chien Ling*. Development of a Matrix-assisted Laser Desorption Ionization Mass Spectrometric Method for Rapid Process-Monitoring of Phthalocyanine Compounds. Analytica Chimica Acta. 736, 69–77, 2012. (SCI)

(11) Chien-Lun Chen, Yue-Fan Lai,, Kun-Yi Chien, Jau-Song Yu, Hsiao-Wei Chen, Petrus Tang, Chia-Wei Hsu, Chi-De Chen, Yu-Sun Chang, Phei-Lang Chang, Yi-Ting Chen*, Comparative and Targeted Proteomic Analyses of Urinary Exosomes from Bladder Cancer and Hernia Patients. J. Proteome Research. 11, 5611−5629, 2012. (SCI)

(12) Yen-Heng Lin*, Ying-Ju Chen, Chao-Sung Lai*, Yi-Ting Chen, Chien-Lun Chen, Jau-Song Yu, and Yu-Sun Chang, A negative-pressure-driven microfluidic chip for the rapid detection of a bladder cancer biomarker in urine using bead-based enzyme-linked immunosorbent assay. Biomicrofluidics 7, 024103, 2013. (SCI)

(13) Chien-Lun Chen, Tsung-Shih, Lin, Cheng-Han, Tsai, Chih-Ching Wu, Ting Chung, Kun-Yi Chien, Maureen Wu, Yu-Sun Chang, Jau-Song Yu*, Yi-Ting Chen*, Identification of Potential Bladder Cancer Markers in Urine by Abundant-Protein Depletion Coupled with Quantitative Proteomics. J. Proteomics. 85, 28-43, 2013. (SCI)

(14) Chi-De Chen, Chih-Liang Wang, Chia-Jung Yu, Kun-Yi Chien, Yi-Ting Chen, Min-Chi Chen, Yu-Sun Chang, Chin-Ching Wu*, Jau-Song Yu*. Targeted Proteomics Pipeline Reveals Potential Biomarkers forthe Diagnosis of Metastatic Lung Cancer in Pleural Effusion. J. Proteome Research. 13(6):2818-29, 2014.

(15) Jun Peng, Yi-Ting Chen, Chien-Lun Chen and Liang Li, Development of a Universal Metabolome-Standard Method for Long-term LC-MS Metabolome Profiling and Its Application for Bladder Cancer Urine-Metabolite-Biomarker Discovery. Anal. Chem. 86(13):6540-7, 2014.

(16) Chiun-Gung Juo*, Chien-Lun Chen, Shiang-Ting Lin, Shu-Hsuan Fu, Yi-Ting Chen, Yu-Sun Chang and Jau-Song Yu. Mass accuracy improvement of ESI-RPLC-MS based urinary metabolomic analysis by post-run calibration using sodium formate cluster ions. Rapid Commun. Mass Spectrom. 28, 1813-1820, 2014.

(17) Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Shi-Liang Chen, Min-Cong Xiao, Chien-Lun Chen, Mu-Yi Hua*. A sensitive and selective magnetic graphene composite-modified polycrystalline-silicon nanowire field-effect transistor for bladder cancer diagnosis. Biosensors and Bioelectronics. 66, 198–207, 2015 . (Co-first author)

(18) Yi-Ting Chen, Li-Ping Tuan, Hsiao-Wei Chen, I-An Wei, Min-Yuan Chou, Han-Min Chen, Yu-Chang Tyan, Sung-Fang Chen*. Quantitative analysis of prostate specific antigen isoforms using immunoprecipitation and isotope dilution mass spectrometry. Anal. Chem. 2015, 87(1):545-53. (Co-first author)

(19) Chien-Lun Chen, Ting Chung, Chih-Ching Wu, Kwai-Fong Ng, Jau-Song Yu, Cheng-Han Tsai, Yu-Sun Chang, Ying Liang, Yi-Ting Chen*. Comparative tissue proteomics of microdissected specimens reveals novel biomarkers of bladder cancer. Mol. Cell Proteomics. 2015. 14(9), 2466-2478. (Co-first and corresponding author)

(20) Chih-Hsiang Chang, Chia-Hung Yang, Huang-Yu Yang, Tien-Hsing Chen, Chan-Yu Lin, Su-Wei Chang, Yi-Ting Chen, Cheng-Chieh Hung, Ji-Tseng Fang, Chih-Wei Yang, Yung-Chang Chen*. Urinary Biomarkers Improve the Diagnosis of Intrinsic Acute Kidney Injury in Coronary Care units. Medicine. 2015 Oct;94(40):e1703.

(21) Chih-Hsiang Chang, Pei-Chun Fan, Chan-Yu Lin, Chia-Hung Yang, Yi-Ting Chen, Su-Wei Chang, Huang-Yu Yang, Chang-Chyi Jenq, Cheng-Chieh Hung, Chih-Wei Yang, and Yung-Chang Chen. Elevation of Interleukin-18 Correlates with Cardiovascular, Cerebrovascular, and Peripheral Vascular Events: A Cohort Study of Hemodialysis Patients. Medicine. 2015 Oct;94(42):e1836.

(22) Cheng-Hung Lee , Kuo-Sheng Liu , Shang-Hung Chang , Wei-Jan Chen , Kuo-Chun Hung , Shih-Jung Liu* , Jong-Hwei S. Pang , Jyuhn-Huarng Juang , Chou Chung-Chuan , Po-Cheng Chang , Yi-Ting Chen , Fu-Shing Wang. Promoting Diabetic Wound Therapy Using Biodegradable rhPDGF-loaded Nanofibrous Membranes: CONSORT-Compliant Article. Medicine. 2015 Nov;94(47):e1873.

(23) Chia-Hung Yang, Chih-Hsiang Chang, Tien-Hsing Chen, Pei-Chun Fan, Su-Wei Chang, Chun-Chi Chen, Pao-Hsien Chu, Yi-Ting Chen, Huang-Yu Yang, Chih-Wei Yang, Yung-Chang Chen. Combination of Urinary Biomarkers Improve Early Detection of Acute Kidney Injury in Patients with Heart Failure. Circulation Journal, 2016, 25;80(4):1017-23.

(24) Cheng-Hung Lee, Yin-Kai Chao, Shang-Hung Chang, Wei-Jan Chen, Kuo-Chun Hung, Shih-Jung Liu,* Jyuhn-Huarng Juang, Yi-Ting Chen and Fu-Shing Wang. Nanofibrous rhPDGF-eluting PLGA–collagen hybrid scaffolds enhance healing of diabetic wounds. RSC Adv., 2016, 6, 6276–6284.

(25) Jau-Song Yu, Yi-Ting Chen, Wei-Fang Chiang, Yung-Chin Hsiao, Lichieh Julie Chu, Lai-Chu See, Chi-Sheng Wu, Hui-Tzu Tu, Hsiao-Wei Chen, Chia-Chun Chen, Wei-Chao Liao, Ya-Ting Chang, Chih-Ching Wu, Che-Yi Lin, Shyun-Yeu Liu, Shu-Ti Chiou, Shu-Li Cha, Kai-Ping Chang, Chih-Yen Chien, Chee-Jen Chang, John D. Young, Chia C. Pao, Yu-Sun Chang*, Leland H. Hartwell*, Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan, PNAS, 2016, 113, 11549–11554. (Co-first author).

(26) Yi-Ting Chen*, Hsiao-Wei Chen, Chun-Feng Wu, Lichieh Julie Chu, Wei-Fang Chiang, Chih-Ching Wu, Jau-Song Yu, Cheng-Han Tsai, Kung-Hao Liang, Yu-Sun Chang, Maureen Wu, Wei-Ting Ou Yang, Development of a multiplexed LC-MRM/MS method for evaluation of salivary proteins as oral cancer biomarkers. Mol. Cell Proteomics. 16, 799-811. 2017.

(27) Chi-hung Shao, Chien-Lun Chen, Chao-Jung Chen, Shu-Hsuan Fu, Yi-Ting Chen, Yu-Sun Chang, Jau-Song Yu, Chiun-Gung Juo*, Kun-Pin Wu*, Metabolite marker discovery for the detection of bladder cancer by comparative metabolomics. Oncotarget, 2017 Jun 13;8(24):38802-38810. 2017.

(28) Yung-Chin Hsiao, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Szu-Fan Chen, Yao-Ning Chuang, Shih-Yu Lin, Chia-Chun Wu, Ya-Ting Chang, Lichieh Julie Chu, Yi-Ting Chen, Shu-Li Chia, Chih-Yen Chien, Kai-Ping Chang,Yu-Sun Chang, and Jau-Song Yu, Development of a multiplexed assay for oral cancer candidate biomarkers using peptide immunoaffinity enrichment and targeted mass spectrometry. Mol. Cell Proteomics. 2017 Oct;16(10):1829-1849.

(29) Cheng-Han Tsai, Yi-Ting Chen*, Clinical proteomics of genitourinary cancer for the development of biomarkers. Clinics in Oncology, 2017, 2, 1326-1327.

(30) Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih-De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang* & Yu-Sun Chang*. APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. NATURE COMMUNICATIONS. 2017, 8: 465.

(31) Yung-Chin Hsiao, Lichieh Julie Chu, Yi-Ting Chen, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Ya-Ting Chang, Szu-Fan Chen, Wei-Shun Wang, Yao-Ning Chuang, Shih-Yu Lin, Chih-Yen Chien, Kai-Ping Chang, Yu-Sun Chang, and Jau-Song Yu. Variability assessment of 90 salivary proteins in intra-day and inter-day samples from healthy donors by multiple reaction monitoring-mass spectrometry. Proteomics Clinical Applications, 2018 Mar;12(2). doi: 10.1002/prca.201700039. Epub 2018 Feb 7.

(32) Cheng-Han Tsai1, Yi-Ting Chen*, Ying-Hsu Chang, Chuen Hsueh, Chung-Yi Liu, Yu-Sun Chang, Chien-Lun Chen*, Jau-Song Yu*. Systematic Verification of Bladder Cancer-Associated Tissue Protein Biomarker Candidates in Clinical Urine Specimens. Oncotarget, 2018, 9:30731-30747. (Co-first author and co-corresponding author).

(33) Cheng-Chia Lee, Chih-Hsiang Chang, Shao-Wei Chen*, Pei-Chun Fan, SuWei Chang, Yi-Ting Chen, Yu-Yun Nan, Pyng-Jing Lin, Feng-Chun Tsai. Preoperative Risk Assessment Improves Biomarker Detection for Predicting Acute Kidney Injury After Cardiac Surgery, PLOS ONE, 2018, 13 (9), e0203447.

(34) Wei-Cheng Lin, Archan Chakraborty, Shih-Chia Huang, Pei-Yu Wang, Ya-Ju Hsieh, Kun-Yi Chien, Yen-Hsien Lee, Chia-Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin, Chang-Shung Tung, Ji-Dung Luo, Ting-Wen Chen, Tzu-Yang Lin, Mei-Ling Cheng, Yi-Ting Chen, Chau-Ting Yeh, Ji-Long Liu, Li-Ying Sung, Ming-Shi Shiao, Jau-Song Yu, Yu-Sun Chang, and Li-Mei Pai*. Histidine-dependent protein methylation is required for compartmentalization of CTP Synthase, Cell Reports, 2018, 24, 2733–2745.

(35) Cheng-Chia Lee, Ya-Ju Hsieh, Shao-Wei Chen, Shu-Hsuan Fu, Chia-Wei Hsu, Chih-Ching Wu, Wei Han, Yunong Li, Huan Tao, Yu-Sun Chang, Jau-Song Yu, Liang Li, Chih-Hsiang Chang, Yi-Ting Chen*, Bretschneider solution-induced alterations in the urine metabolome in cardiac surgery patient. Scientific Reports, 2018, 8, Article number: 17774.

(36) Yi-Ting Chen*, Cheng-Han Tsai, Chien-Lun Chen, Jau-Song Yu, Ying-Hsu Chang*. Development of Biomarkers of Genitourinary Cancer using Mass Spectrometry-Based Clinical Proteomics, Journal of Food and Drug Analysis, 2019, 27, 2: 387-403.

(37) Yi-Ting Chen*, Hsin-Chien Huang, Ya-Ju Hsieh, Shu-Hsuan Fu, Liang Li, Chien-Lun Chen, Lichieh Julie Chu, Jau-Song Yu. Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers. Journal of Food and Drug Analysis, 2019, 27(2), 460-474.

(38) Chia-Wei Hsu, Yi-Ting Chen, Ya-Ju Hsieh, Kai-Ping Chang, Pei-Chun Hsueh, Ting-Wen Chen, Jau-Song Yu, Yu-Sun Chang, Liang Li*, Chih-Ching Wu*. Integrated analyses utilizing metabolomics and transcriptomics reveal perturbation of the polyamine pathway in oral cavity squamous cell carcinoma. Analytica Chimica Acta. 2019, 1050, 113-122. (Co-first author)

(39) Jia-Jin Chen, Pei-Chun Fan, George Kou, Su-Wei Chang, Yi-Ting Chen, Cheng-Chia Lee, Chih-Hsiang Chang*, Meta-analysis: urinary calprotectin for discrimination of intrinsic and prerenal acute kidney injury, J. Clin. Med., 2019, 8(1), E74.

(40) Pei-Chun Fan, Jason Chih-Hsiang Changa, Chia-Ni Lin,Cheng-Chia Leea, Yi-Ting Chen, Pao-Hsien Chu, George Koua, Yueh-An Lu, Chih-Wei Yang, Yung-Chang Chen*. Serum Indoxyl Sulfate Predicts Adverse Cardiovascular Events in Patients with Chronic Kidney Disease. Journal of the Formosan Medical Association, 2019, 118, 1099-1106.

(41) Hao-Wei Chu, Kai-Ping Chang, Chia-Wei Hsu, Ian Yi-Feng Chang, Hao-Ping Liu, Yi-Ting Chen, and Chih-Ching Wu, Identification of salivary biomarkers for oral cancer detection with untargeted and targeted quantitative proteomics approaches. Molecular & Cellular Proteomics. 2019, 18(9), 1796-1806.

(42) Yi-Ting Chen*, Wei-Ting Ou Yang, Horng-Heng Juang, Chien-Lun Chen*, Hsiao-Wei Chen, Ke-Hung Tsui, Ying-Hsu Chang, Cheng-Han Tsai, Chuen Hsueh, Wei-Chao Liao, Proteomic characterization of arsenic and cadmium exposure in bladder cells", Rapid Commun Mass Spectrom. 2020;34(S1):e8578.

(43) Cheng-Chia Lee, Chih-Hsiang Chang, Ya-Lien Cheng, George Kuo, Shao-Wei Chen, Yi-Jung Li, Yi-Ting Chen, Ya-Chung Tian*, Diagnostic performance of Cyclophilin A in cardiac surgery-associated acute kidney injury. J. Clin. Med. 2020, 9, 108; doi:10.3390/jcm9010108.

(44) Pei-Chun Hsueh; Kuo-An Wu; Chia-Yu Yang; Chia-Wei Hsu; Chih-Liang Wang; Chu-Mi Hung; Yi-Ting Chen; Jau-Song Yu; Chih-Ching Wu*. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Analytica Chimica Acta. 2020, 1128, 238-250.

(45) Jo-Chuan Liu, Yi-Ting Chen, Ya-Ju Hsieh, Chia-Chun Wu, Ming-Chyi Huang, Yu-Chao Hsu, Chun-Te Wu, Chih-Ken Chen, Srinivas Dash & Jau-Song Yu*. Association of urinary ketamine and APOA1 levels with bladder dysfunction in ketamine abusers revealed via proteomics and targeted metabolite analyses. Sci. Rep. 11, 9583 (2021). https://doi.org/10.1038/s41598-021-89089-4.

(46) Jia‑You Lin, Bao‑Rong Juo, Yu‑Hsuan Yeh, Shu‑Hsuan Fu, Yi‑Ting Chen, Chien‑Lun Chen* and Kun‑Pin Wu*. Putative markers for the detection of early-stage bladder cancer selected by urine metabolomics, BMC Bioinformatics. 2021, 22, 305. https://doi.org/10.1186/s12859‑021‑04235‑z.

(47) Ming-Yu Fang, Kuan-Hsun Huang, Wei-Ju Tu, Yi-Ting Chen, Pei-Yun Pan, Wan-Chi Hsiao, Yi-Yu Ke, Lun K. Tsou, Mingzi M. Zhang*. Chemoproteomic profiling reveals cellular targets of nitro-fatty acids. Redox Biology. 46, 102126 (2021). https://doi.org/10.1016/j.redox.2021.102126.

(48) Ya-Ju Hsieh, Kun-Yi Chien, Chun-Ming Chang, Cheng-Yu Hung, Liang Li, Wei-Fan Chiang5, Cheng-Chia Lee, Chih-Hsiang Chang, Ying-Hsu Chang, Jau-Song Yu*, Yi-Ting Chen*. Development of a Method for Dansylation of Metabolites Using Organic Solvent-Compatible Buffer Systems for Amine/Phenol Submetabolome Analysis. Analytica Chimica Acta. 2022, 1189, 339218. https://doi.org/10.1016/j.aca.2021.339218

(49) Eric Yi-Hsiu Huang, Yu-Kuang Chen, Chen-Pu Ou, Yi-Ting Chen, Sung-Fang Chen, William J. Huang, Kung-Hao Liang * Oncogenic roles of Polycomb Repressive Complex 2 in bladder cancer and upper tract urothelial carcinoma. Biomedicines. 2022 Nov 14;10(11):2925. doi: 10.3390/biomedicines10112925.

(50) Yi-Ting Chen, Wan-Rou Liao, Hsueh-Ting Wang, Hsiao-Wei Chen, Sung-Fang Chen*. Targeted Protein Quantitation in Human Body Fluids by Mass Spectrometry. Mass Spectrom Rev. 2023.; 42(6):2379-2403. doi: 10.1002/mas.21788.

(51) Chien-Lun Chen, Yi-Ting Chen, Wen-Yu Liao, Yu-Sun Chang, Jau-Song Yu, and Bao-Rong Juo*, Urinary Metabolomic Analysis of Prostate Cancer by UPLC-FTMS and UPLC-Ion Trap MSn. Diagnostics. 2023, 13, 2270. https://doi.org/10.3390/diagnostics13132270

(52) Yi-Ting Chen*, Wei-Ju Tu, Zong-Han Ye, Chih-Ching Wu, Shir-Hwa Ueng, Kai-Jie Yu, Chien-Lun Chen, Pei-Hua Peng, Jau-Song Yu, Ying-Hsu Chang*, Integration of the cancer cell secretome and transcriptome reveals potential noninvasive diagnostic markers for bladder cancer. Proteomics Clin. Appl. 2024 Jan 9:e2300033. https://onlinelibrary.wiley.com/doi/10.1002/prca.202300033.

(53) Chih-Hsiang Chang, Cheng-Chia Lee, Yung-Chang Chen, Pei-Chun Fan, Pao-Hsien Chu, Lichieh Julie Chu, Jau-Song Yu, Hsiao-Wei Chen, Chih-Wei Yang, Yi-Ting Chen*. Identification of endothelial cell protein c receptor by urinary proteomics as a novel prognostic marker in non-recovery kidney injury, International Journal of Molecular Sciences, 2024, 25(5), 2783; https://doi.org/10.3390/ijms250527834.

Selected Patents (Total items >30)

1. 陳怡婷、余兆松、陳建綸、張玉生 (2013) 膀胱癌之生物標記及其檢測方法。中華民國專利發明第I390204號。

2. 陳怡婷、余兆松、陳建綸、張玉生 (2016) 尿液生物標記作為預測膀胱及腎臟癌的用途。中華民國專利發明第I522367號。

3. 陳怡婷、張鈺、陳建綸、張英勛、陳建綸、虞凱傑、張榮興(2023)，腎臟罹癌風險之判斷方法，中華民國專利發明第I817329號。

Awards

1. Scholarship award of Chung Hwa Rotary Educational Foundation, 1999-2000, Taiwan.
2. The best paper awards, Industrial Technology Research Institute, 2010 & 2007, Taiwan.
3. The excellent paper award, Association of Chemical Sensors in Taiwan, 2015.
4. TSMS Young Scholar Award, Taiwan Society for Mass Spectrometry, 2017.
5. Young Scholar Award, LCY Education Foundation, 2018, Taiwan.