Chang Gung University

CurrentJob： Chairman of Department and Graduate Institute of Medical Biotechnology and Laboratory Science

Expertise： Immuno-Regulation, Immunotherapy and Vaccine Development, Gene Therapy, Clinical Laboratory Science, Molecular Imaging

Research Direction

Prof. Chia-Rui Shen received a Ph.D. degree in Immunology from the University of Bristol in United Kingdom, and now is a professor also the Chair at Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taiwan. Dr. Shen was one of the Council members in the Chinese Society of Immunology (Taipei) (2012-2018) and the Taiwan Artificial Intelligence Application Association (2019-2022). Also, she is the Council member in the Taiwan Society of Chitin and Chitosan (2009-), and the Executive Supervisor in the Taiwan Artificial Intelligence Application Association (2022-). The immune system always attracts attentions due to its efficient induction of antigen specific responses. Dr. Shen’s “Medical Immunology Lab” aims to understand the regulation of autoreactive T cell responses and develop specific immunotherapies, gene and cell therapies against hypersensitivity as well as tumors.

Publications

Chen YS, Hwang CH, Liu CL, Chen HS, Wu ST, Lee MH, Shen CR (correspondence). Locally targeting the IL-17/ IL-17RA axis reduced tumor growth in a murine B16F10 melanoma model. Hum Gene Ther 2019 Mar; 30(3):273-285. SCI=5.695 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY, 15.09%) (CMRPD3B0053, CORPD1F0031-3, BMRP440)
Barker NM, Li YX, Lee MM, Shen CR, Krause JA, Sun SS, Lu N, Connick WB, and McMillin DR. Synthesis, luminescence, and structure of a polymorphic polyfluorinated diiodoplatinum (II) diimine complex. Inorg Chem. 2019 Aug; 58(16):10716-10724. SCI=5.165 (CHEMISTRY, INORGANIC & NUCLEAR, 11.11%)
Elakkat V, Chang CC, Chen JY, Fang YC, Shen CR (correspondence), Liu LK, Lu N. The first two examples of halogen bonding with a sigma hole-donating fluorine in the Csp3–F⋯Osp3 interaction from polyfluorinated trans-dihalo-palladium(II) di-substituted pyridine complexes. Chem Commun (Camb). 2019 Nov; 55(95):14259-14262.SCI=6.222 (CHEMISTRY, MULTIDISCIPLINARY, 24.72%)(MOST108-2320B-182-032)
Lin HC, Chen CY, Kao CW, Wu ST, Chen CL Shen CR, Juang JH, IM Chu. In situ gelling-polypeptide hydrogel systems for the subcutaneous transplantation of MIN6 cells. J Polym Res. 2020 Feb; 27, 64. SCI=3.097 (POLYMER SCIENCES, 40.91%)
Shen CR, Chen YS, Hwang YS, Chen HJ, Liu CL. Differential bicistronic gene translation mediated by the internal ribosome entry site element of encephalomyocarditis virus. Biomed J 2020 Jun. doi:10.1016/j.bj.2020.06.006. SCI=4.910 (BIOCHEMISTRY&MOLECULAR BIOLOGY, 31.99%) (MOST105-2221-E-131-035, BMRP440, CMRPD1I0071-2)
Chiu CF, Ho JH, Tessema E, Lu Y, Shen CR, Lin CW, Lu N. Short-chained platinum complex catalyzed hydrosilylation under thermomorphic conditions: heterogeneous phase separation at ice temperature.. Molecules 2021 Jan; 26(2):378. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
Tessema E, Elakkat V, Chiu CF, Zheng JH, Chan KL, Shen CR, Zhang P, Lu N. Recoverable Phospha-Michael additions catalyzed by a 4-N,N-dimethylaminopyridinium saccharinate salt or a fluorous long-chained pyridine: two types of reusable base catalysts. Molecules 2021 Feb; 26(4):1159. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
Tessema E, Elakkat V, Chiu CF, Tsai ZL, Chan KL, Shen CR, Su HC, Lu N. Recoverable palladium‐catalyzed carbon‐carbon bond forming reactions under thermomorphic mode: Stille and Suzuki‐Miyaura reactions. Molecules 2021 Mar; 26(5), 1414. SCI=4.411 (CHEMISTRY, MULTIDISCIPLINARY, 35.39%)
Juang JH, Lin HC, Chen CY, Kao CW, Chen CL, Wu ST, Lin SH, Shen CR, Wang JJ, Tsai ZT, Chu IM. Noninvasive tracking of mPEG-poly(Ala) hydrogel-embedded MIN6 cells after subcutaneous transplantation in mice. Polymers 2021 Mar; 13(6), 885. SCI=4.329 (POLYMER SCIENCE, 20.45%)
Juang JH, Wang JJ, Shen CR (equal to first), Chen CY, Kao CW, Chen CL, Lin SH, Wu ST, Li WC, Tsai ZT. Magnetic resonance imaging of transplanted porcine neonatal pancreatic cell clusters labeled with chitosan-coated superparamagnetic iron oxide nanoparticles in mice. Polymers 2021 Apr; 13(8), 1238. SCI=4.329 (POLYMER SCIENCE, 20.45%)
Lo SM, Hwang YS, Liu CL, Shen CN, Hong WH, Yang WC, Lee MH, Shen CR (correspondence). Inhibiting TLR7 expression in the retinal pigment epithelium suppresses experimental autoimmune uveitis. Front Immunol (in revision) 2021. SCI=7.561 (IMMUNOLOGY, 14.81%) (MOST 109-2320-B-182-037, CMRPD1I0071-2, BMRP440)
Hsu LJ, Liu CL, Kuo ML, Shen CN, Shen CR (correspondence). An alternative cell therapy for cancers: induced pluripotent stem cell (iPSC)-derived natural killer cells. Biomedicines (in revision) 2021. SCI=6.081 (BIOCHEMISTRY & MOLECULAR BIOLOGY, 14.81%) (MOST 109-2320-B-182-037, CMRPD1H0621, CMRPD1K0491, BMRP440)
Juang JH, Shen CR (equal to first),Wang JJ, Wu ST, Lin SH, Chen CY, Kao CW, Chen CL, Wang YM. Exendin-4-conjugated manganese magnetism-engineered iron oxide nanoparticles as a potential magnetic resonance imaging contrast agent for tracking transplanted b-cells. (in revision) 2021.

Awards

2021 Invited Speech, the 11th International Congress of Diabetes and Metabolism (ICDM) (Virtual meeting, Korea, 7th -9th Oct, 2021)
2020 Distinguished Alumni, College of Medicine, National Cheng Kung University, Taiwan.
2019 Excellence Award and Merit Award, AI Smart Application New Generation Talent Cultivation Program, Industry Development Bureau, Ministry of Economic Affairs.
2017, 2018 College Student Research Creativity Award (Supervisor), Ministry of Science and Technology (MOST), Taiwan.
2017, 2019 Invited Speech, The Asia Islet Biology and Incretin Symposium (AIBIS), Seoul, Korea.
2015 Outstanding Faculty Teaching Award, Chang Gung University, Taiwan