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Master & PhD Program in Biotechnology Industry

Master & PhD Program in Biotechnology Industry
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Yen-Heng Lin

Yen-Heng Lin

JobTitle： Professor

CurrentJob： Professor

E-mail： yenheng@mail.cgu.edu.tw

Phone： 3789

Education： Ph.D. in Engineering Science, National Cheng Kung University, Taiwan

Expertise： Design and Fabrication of Microfluidic Device, Optoelectronic Tweezers, MEMS, Fabrication of Nanowire sensor

Website： https://sites.google.com/site/bolcgu/

Research Direction

1. Development of biomedical electronic medical testing instruments

2. The rapid PCR platform is applied to the detection of pathogenic bacteria

3. Microdroplet coating DNA and cell technology

4. Photoelectric biomedical particle control platform

Publications


Update 2013.04.15
(A) Journal paper:
Sum of the Times Cited: 493 (Scopus database)
h-index: 10
A1. Yen-Heng Lin*, Anirban Das, and Chao-Sung Lai*, A simple and convenient set-up of light addressable potentiometric sensors (LAPS) for chemical imaging using a commercially available projector as a light source, International Journal of Electrochemical Science, In press, 2013.
A2. Yen-Heng Lin*, Anirban Das, Min-Hsien Wu, Tung-Ming Pan, and Chao-Sung Lai*, “Microfluidic chip integrated with an electrolyte-insulator-semiconductor sensor for pH and glucose level measurement, ” International Journal of Electrochemical Science, Vol. 8, pp. 5886- 5901, 2013.
A3. Yen-Heng Lin*, Ying-Ju Chen, Chao-Sung Lai*, Yi-Ting Chen, Chien-Lun Chen, Jau-Song Yu, and Yu-Sun Chang, “A negative-pressure-driven microfluidic chip for the rapid detection of a bladder cancer biomarker in urine using bead-based ELISA,” Biomicrofluidics, Vol. 7, pp. 024103, 2013.
A4. Atanu Das, Anirban Das, Liann-Be Chang*, Chao-Sung Lai, Ray-Ming Lin, Fu-Chuan Chu, Yen-Heng Lin, Lee Chow, and Ming-Jer Jeng, “GaN Thin Film Based Light Addressable Potentiometric Sensor for pH Sensing Application,” Applied Physics Express, Vol. 6, pp. 036601, 2013.
A5. Song-Bin Huang, Min-Hsien Wu, Yen-Heng Lin, Chia-Hsun Hsie, Chih-Liang Yang, Hung-Chih Lin, Ching-Ping Tseng*, and Gwo-Bin Lee*, “High-purity and label-free isolation of circulating tumor cells (CTCs) in a microfluidic platform by using optically-induced-dielectrophoretic (ODEP) force,” Lab on a chip, Vol. 13, pp. 1371-1383, 2013.
A6. Yen-Heng Lin*, Shih-Hao Wang, Min-Hsien Wu, Tung-Ming Pan, Chao-Sung Lai, Ji-Dung Luo, and Chiuan-Chian Chiou, “Integrating solid-state sensor and microfluidic devices for glucose, urea and creatinine detection based on enzyme-carrying alginate microbeads,” Biosensors and Bioelectronics, Vol. 43, pp. 328-335, 2013.
A7. Yen-Heng Lin, Ya-Wen Yang, Yi-Dao Chen, Shih-Siou Wang, Yu-Han Chang*, and Min-Hsien Wu*, “The application of an optically switched dielectrophoretic (ODEP) force for the manipulation and assembly of cell-encapsulating alginate microbeads in a microfluidic perfusion cell culture system for bottom-up tissue engineering,” Lab on a chip, Vol. 12, pp. 1164-1173, 2012.
A8. Yen-Heng Lin*, Chien-Hung Chiang, Min-Hsien Wu, Tung-Ming Pan, Ji-Dung Luo, and Chiuan-Chian Chiou, “Solid-state sensor incorporated in microfluidic chip and magnetic-bead enzyme immobilization approach for creatinine and glucose detection in serum,” Applied Physics Letters, Vol. 99, pp. 253704, 2011.
A9. Yen-Heng Lin and Gwo-Bin Lee*, “An integrated cell counting and continuous cell lysis device using optically induced dielectrophoresis,” Sensors and Actuators B: Chemical, Vol. 145, pp. 854-860, 2010.
A10. Wei Wang, Yen-Heng Lin, Ten-Chin Wen, Tzung-Fang Guo, and Gwo-Bin Lee*, “Selective manipulation of microparticles using polymer-based optically-induced dielectrophoretic devices,”Applied Physics Letters, Vol. 96, pp. 113302, 2010.
A11. Shih-Hsun Hung, Yen-Heng Lin, and Gwo-Bin Lee*, “A new platform for manipulation and separation of oil-in-water emulsion droplets using optically induced dielectrophoresis,” Journal of Micromechanics and Microengineering, Vol. 20, pp. 045026, 2010.
A12. Ming-Wei Lee, Yen-Heng Lin, and Gwo-Bin Lee*, “A platform to manipulate carbon nanotubes utilizing optically-induced dielectrophoretic forces,” Microfluidics and Nanofluidics, Vol. 8, pp. 609-617, 2010.
A13. Wang-Ying Lin, Yen-Heng Lin, and Gwo-Bin Lee*, “Optically-induced Dielectrophoretic Forces for Continuous Micro-particle Separation,” Microfluidics and Nanofluidics, Vol. 8, pp. 217-229, 2010.
A14. Wei Wang, Yen-Heng Lin, Ruei-Syuan Guan, Ten-Chin Wen, Tzung-Fang Guo, and Gwo-Bin Lee*, “Bulk-heterojunction polymers in optically-induced dielectrophoretic devices for the manipulation of microparticles,” Optics Express, Vol. 17, pp. 17603-17613, 2009.
A15. Yen-Heng Lin, Chen-Min Chang, and Gwo-Bin Lee*, “Manipulation single DNA molecule by using optically-induced dielectrophoresis,” Optics Express, Vol. 17, pp. 15318-15329, 2009.
A16. Yen-Heng Lin and Gwo-Bin Lee*, “An Optically-Induced Cell Lysis Device Using Dielectrophoresis,” Applied Physics Letters, Vol. 94, pp. 033901, 2009.
A17. Chen-Yi Lee, Yen-Heng Lin, and Gwo-Bin Lee*, “Droplet-Based Microfluidic System Capable of Droplet Formation and Manipulation,” Microfluidics and Nanofluidics, Vol. 6, pp. 599-610, 2009.
A18. Yen-Heng Lin and Gwo-Bin Lee*, “Optically-induced Flow Cytometry for Continuous Microparticle Counting and Sorting,” Biosensors and Bioelectronics, Vol. 24, pp. 572-578, 2008.
A19. Chia-Wei Lai, Yen-Heng Lin, and Gwo-Bin Lee*, “A Microfluidic Chip for Formation and Collection of Emulsion droplets Utilizing Active Pneumatic Micro-choppers and Micro-switches,”Biomedical Microdevices, Vol. 10, pp. 749-756, 2008.
A20. Yen-Heng Lin, Chun-Hong Lee, and Gwo-Bin Lee*, “Droplet Formation Utilizing Controllable Moving-wall Structures for Double Emulsion Applications,” Journal of Microelectromechanical Systems, Vol. 17, pp. 573-581, 2008.
A21. Yen-Heng Lin, Cheng-Tso Chen, Lynn L.H. Huang, and Gwo-Bin Lee*, “Multiple-channel Emulsion Chips Utilizing Pneumatic Choppers for Biotechnology Applications,” Biomedical Microdevices, Vol. 9, pp. 833-843, 2007.
A22. Lung-Ming Fu, Gwo-Bin Lee*, Yen-Heng Lin, and Ruey-Jen Yang, ”Manipulation of Micro-particles Using New Modes of Travelling-wave-dielectrophoretic Forces - Numerical Simulation and Experiments,” IEEE/ASME Transactions on Mechatronics, Vol. 9, pp. 377-383, 2004.
A23. Gwo-Bin Lee*, Shu-Hui Chen, Chin-She Lin, Guan-Ruey Huang, and Yen-Heng Lin, “Microfabricated Electrophoresis Chips on Quartz Substrates and Their Applications on DNA Analysis, “, Journal of The Chinese Chemical Society, Vol. 48, No. 6B, 2001.
A24. Che-Hsin Lin, Gwo-Bin Lee*, Yen-Heng Lin, and Guang-Liang Chang, “A Fast-Prototyping Process for Fabrication of Microfluidic Systems on Soda-Lime Glass,“ Journal of Micromechanics and Microengineering, Vol. 11, pp. 726-732, 2001. Highly cited papers in 10 years, top 1% selected by ISI.
A25. Gwo-Bin Lee*, Shu-Hui Chen, Guan-Ruey Huang, Wang-Chou Sung, and Yen-Heng Lin, “Microfabricated Plastic Chips by Hot Embossing Methods and Their Applications for DNA Separation and Detection, “ Sensors and Actuators B: Chemical, Vol. 75, pp. 142-148, 2001. Highly cited papers in 10 years, top 1% selected by ISI.

(B) Conference paper:
International conference paper:
B1. Chia-Chu Wang, Yen-Heng Lin*, Kin-Fong Lei, “A chaotic bubble mixer microfluidic device for rapid detection of bladder cancer using bead-based ELISA,” IEEE-NEMS 2013, Suzhou, China.
B2. Anirban Das, Yen-Heng Lin*, Tatsuo YOSHINOBU, and Chao-Sung Lai*, “A Novel Flexible Chemical Imaging Set-Up of Amorphous- Si-Based Light-Addressable Potentiometric Sensor Using Video Projector as a Programmable Scanning Light Source,” IMCS 2012, Nuremberg, Germany.
B3. Shih-Hao Wang, Yen-Heng Lin*, Chih-Pin Chu, Min-Hsien Wu, Tung-Ming Pan, “Integration of Solid-state Sensor and Microfluidic Chip for Glucose, Urea, and Creatinine Measurement,” IEEE-NEMS 2012, Kyoto, Japan.
B4. Ying-Ju Chen, Yen-Heng Lin*, Chao-Sung Lai, Yi-Ting Chen, Jau-Song Yu, and Yu-Sun Chang, “A syringe-vacuum driven microfluidic chip integrated with beads-based ELISA for early setection of bladder cancer,” Micro-TAS 2011, Seattle, USA.
B5. Yen-Heng Lin*, Anirban Das, Kai-Siang Ho, Yu-Jen Pan, Chao-Sung Lai, Liann-Be Chang, “Investigation of possibility of generating high resolution chemical image by using light-addressable potentiometric sensor with amorphous silicon as substrate and commercial projector as light source,” ISMM 2011, Seoul, Korea.
B6. Yen-Heng Lin*, Anirban Das, Kai-Siang Ho, Chao-Sung Lai, “A Novel Light-Addressable Potentiometric Sensors Set-Up with LCD Projector as Scanning Light Source,” IEEE NEMS 2011, Kaohsiung, R.O.C.
B7. S.-J. Lin, W. Wang, Y.-H. Lin, B.-C. Yeh, T.-F. Guo, G.-B. Lee*, “Separation and manipulation of micro-particles using optical images on flexible polymer devices,” IEEE MEMS 2011, Cancun, Mexico.
B8. Yen-Heng Lin and Gwo-Bin Lee*, “Continuous cell lysis devices using optically-induced electric field,”ASME-MNHMT 2009, Shanghai, China. (Invited talk co-author)
B9. Yen-Heng Lin, Chen-Min Chang, and Gwo-Bin Lee*, “A new platform for manipulating a single DNA molecule by using optically-induced dielectrophoresis,”Transducer 2009, Denver, USA. (Oral presentation)
B10. Gwo-Bin Lee*, Yen-Heng Lin, Wang-Ying Lin, Wei Wang, and Tzung-Fang Guo, “Optically-induced dielectrophoresis using polymer materials for biomedical applications,”Transducer 2009, Denver, USA. (Invited talk co-author)
B11. Shih-Hsun Hung, Yen-Heng Lin and Gwo-Bin Lee*, A new platform for manipulation and separation of oil-in-water emulsion droplets using optically induced dielectrophoresis,’ Transducer 2009, Denver, USA.
B12. Wang-Ying Lin, Yen-Heng Lin and Gwo-Bin Lee*, “Continuous micro-particle separation using optically-induced dielectrophoretic forces,” IEEE-MEMS 2009, Sorrento, Italy. (Oral presentation co-author)
B13. Wei Wang, Yen-Heng Lin, Tzung-Fang Guo and Gwo-Bin Lee*, “Manipulation of biosamples and microparticles using optical images on polymer devices,” IEEE-MEMS 2009, Sorrento, Italy.
B14. Yen-Heng Lin and Gwo-Bin Lee*, “A new micro flow cytometer using optically-induced dielectrophoretic forces for continuous microparticle counting and sorting,”Micro-TAS 2008, San Diego, USA. (Oral presentation)
B15. Chen-Yi Lee, Yen-Heng Lin and Gwo-Bin Lee*, “A new microfluidic device for formation and switching of micro-droplets,” Micro-TAS 2008, San Diego, USA.
B16. Yen-Heng Lin, Chun-Hong Lee and Gwo-Bin Lee*, “A New Droplet Formation Chip Utilizing Controllable Moving-wall Structures for Double Emulsion Applications,” IEEE-MEMS 2008, Tucson, USA. (Oral presentation)
B17. Che-Hsin Lin, Gwo-Bin Lee*, Yen-Heng Lin and Guang-Liang Chang, “A Fast-Prototyping Process for Fabrication of Microfluidic Systems on Soda-Lime Glass Substrates,“The 2nd Cross-Strait Symposium on Microsystem Technologies, Hung-Chou, China, Oct. 29-31, 2001.
B18. Gwo-Bin Lee*, Cheng-I Hung, Bin-Jo Ke, Guan-Ruey Huang, Bao-Herng Hwei, Yen-Heng Lin, Wan-Yu Wu, “ Development of high-throughput microfluidic chips with continuous sample introduction and separation functions,” International Symposium on Smart Structures and Microsystems (IS3M), Hong Kong, October 19-21, 2000.
B19. Gwo-Bin Lee*, Guan-Ruey Huang, Yen-Heng Lin, Wang-Chou Sung, Shu-Hui Chen, “Microfabricated Plastic Chips by Hot Embossing Methods and Their Applications for DNA Separation and Detection, “ SPIE micromachining and microfabrication, Santa Clara, CA, USA, September 18-20, 2000, pp. 113-122. (EI)
Other conference paper:
B20. Kai-Siang Ho, Yen-Heng Lin*, Tsung-Cheng Chen, Chin-Tien Yang, Jung-Hao Wang, and Chao-Sung Lai, “A new platform for assembling nanowire sensor by using the combination of optically switched dielectrophoresis and dielectrophoresis,” 2013 SEMBA, Tainan.
B21. 王嘉駒, 林彥亨*, 李健峰, “高效率氣泡混合微流體裝置結合磁珠式酵素連結免疫分析法應用於膀胱癌之檢測,” 2012生物醫學工程科技研討會, 中壢, 桃園 (壁報論文優等獎)
B22. 楊志亮, 黃菘斌, 邱子耕, 林彥亨, 吳旻憲*, “應用光介電泳力之微流體平台於高純度純化分離已利用傳統方法篩選之循環腫瘤細胞,” 2012生物醫學工程科技研討會, 中壢, 桃園 (壁報論文優等獎)
B13. Ying-Ju Chen, Yen-Heng Lin*, Chao-Sung Lai, Yi-Ting Chen, Jau-Song Yu, and Yu-Sun Chang, “Development of microfluidic chip for rapid detection of biomarker,” 第十屆台塑關係企業應用技術研討會, 龜山, 桃園
B24. Yen-Heng Lin*, Shih-Hao Wang, Chih-Pin Chu, Tung-Ming Pan, Chao-Sung Lai, Ji-Dung Luo, Chiuan-Chian Chiou, “An solid-state sensor incorporated microfluidic chip for human blood monitoring,” 2012 Symposium on Emerging Technologies in Biomedical & Healthcare Applications, Taoyuan, Taiwan.
B25. Yen-Heng Lin*, Chien-Hung Chiang, Tung-Ming Pan, Min-Hsien Wu, “An Enzyme Immobilization Method for Creatinine and Glucose measurement in microfluidic chip,” 2012 SEMBA, Taichung.
B26. Ying-Ju Chen, Yen-Heng Lin*, Chao-Sung Lai, Yi-Ting Chen, Jau-Song Yu, and Yu-Sun Chang, “An Integrated Microfluidic Chip for Rapid Detection of Bladder Cancer,” 2012 SEMBA, Taichung.
B27. 林彥亨*, 王世豪, 潘同明, 吳旻憲, 賴朝松, “血糖、尿素、肌酐酸ISFET微流體感測晶片,” 2011第十五屆奈米工程暨微系統技術研討會, 台北 (大會最佳論文獎)
B28. Ya-Wen Yang, Yen-Heng Lin, Yi-Dao Chen, Min-Hsien Wu*, „The Assembly of Cell-Encapsulated Microgel Particles in a Microfluidic System Using Optically Induced Dielectrophoretic (ODEP) Force for Structurally-Controllable Cartilage Tissue Engineering,” 2011生物醫學工程科技研討會, 台南 (壁報論文特優獎)
B29. Yen-Heng Lin*, Chien-Hung Chiang, Tung-Ming Pan, Min-Hsien Wu, Chao-Sung Lai, “A novel enzyme deliver approach for glucose sensing in electrolyte-insulator-semiconductor embedded microfluidic chip,” 2011 SEMBA, Dashu, Kaohsiung.
B30. 林彥亨*, 王世豪, 潘同明, 吳旻憲, 賴朝松, “新式酵素固定技術應用於EIS微流體血糖感測晶片,” 第九屆台塑關係企業應用技術研討會, 龜山, 桃園 (績優獎論文)
B31. Yen-Heng Lin and Gwo-Bin Lee*, “A new platform for manipulating cells by using optically-induced dielectrophoretic force, “The 33rd National Conference on Theoretical and Applied Mechanics, Miaoli, Taiwan, November 13-14, 2009.
B32. 黃聖傑, 林彥亨, 李國賓* “製備膠原蛋白微粒之新型微流體晶片,” 第十一屆奈米工程暨微系統技術研討會, 台中, August 30-31, 2007.
B33. Chia-Wei Lai, Yen-Heng Lin, Cheng-Tso Chen and Gwo-Bin Lee*, „A Microfluidic Chip for Formation and Sorting of droplets Utilizing Active Pneumatic Micro-choppers and Micro-switches,”The 23rd Annual Conference on Mechanical Engineering, Dec., 2006.
B34. 林彥亨，李國賓*，傅龍明，楊瑞珍, “利用介電泳力操控細胞之生物晶片研究,” 第十九屆機械工程研討會, 雲林，虎尾Nov. 29-30, 2002.


Awards

  1. Guiding undergraduate students Hong Jiaze and Huang Guanbo to participate in the Taipei Innovation Laboratory 20X23 Angel Talent Show & Entrepreneur Annual Meeting, Investment and Entrepreneurship Golden Idea Group Winner
  2. Guiding undergraduate students Hong Jiaze and Huang Guanbo to participate in the 2022 Sixth National Medical Engineering Creativity Competition, College Group Excellent Works
  3. Guiding undergraduate students Hong Jiaze and Huang Guanbo to participate in the third place in the 2022 Chang Gung Memorial University [Gengxin Cup] Campus Innovation and Entrepreneurship Competition
  4. Guiding undergraduate special subject student Zeng Peiqi to participate in the 2019 ICSS and win the Honorary Poster Award.
  5. Guided student Peng Yongsheng to participate in the 15th (2017) Application Technology Seminar of Formosa Plastics Related Enterprises, and won the school group award for "Microfluidic Chip for Autoimmune Antibody Detection in Rapid Screening of Oral Cancer".
  6. Guided undergraduate special subject student Xu Jinghongxue to participate in the 2016 Xutai Science and Technology Paper Award, and won the Outstanding Creativity Award for his "X-Y-Z Platform Application for Rapid Production of Transdermal Drug Release Microneedle Arrays".
  7. Guided undergraduate student Xu Jinghong to participate in the 2016 Engineering Paper Competition of the Student Branch of the Chinese Society of Engineers, and won the Excellence Award for his "Rapid Production Method of Microneedle Array Molds with Controllable Needle Height and Bottom Width".
  8. Guided student Peng Yongsheng to participate in the 2015 Biomedical Engineering Technology Symposium, and won the first prize in the biomedical sensing group of the poster paper competition with his "Microfluidic detection chip for autoimmune antibody detection and its application in rapid screening of oral cancer".
  9. Guided Wu Jiawei to participate in the 2015 Chemical Sensors Association Symposium, and won the oral paper competition excellence award for "Combining Microfluidics and Mass Spectrometry Analysis Technology to Realize Rapid Preprocessing of Biomarker Samples for Cancer Diagnosis and Prognosis Assessment".
  10. Guided student Su Weiting to participate in the 2015 Chemical Sensors Association Symposium, and won the excellent oral paper competition award for her article "Microfluidic chips for rapid cancer screening using multiple peptide mass spectrometry sample preprocessing".
  11. Guided He Kaixiang to participate in the 2013 SEMBA Biomedical Engineering Application Symposium, and won the best paper award at the conference with "A new platform for assembling nanowire sensor by using combination of optically switched dielectrophoresis and dielectrophoresis".
  12. Guided student Peng Baiyou to participate in the 2013 Quanyan Science and Technology Master's Thesis Award, and won the Outstanding Creative Work Award for his "Immunoanalytical Transistor Combined with Innovative DNA Markers for Rapid Bladder Cancer Detection".
  13. Guided student He Kaixiang to participate in the 2012 National Nanotechnology Application Creativity Competition and won the silver medal for his project "Applying Optical Dielectrophoresis Force to the Assembly of Nanowire Sensing Components".
  14. Guided student Wang Jiaju to participate in the 2012 Biomedical Engineering Technology Symposium, and won the first prize in the poster paper competition with "High-efficiency bubble mixing microfluidic device combined with magnetic bead enzyme-linked immunoassay method for detection of bladder cancer".
  15. Guided classmate Wang Shihao to participate in the 15th Nano Engineering and Microsystem Technology Symposium, and won the best paper award at the conference for his "Blood Glucose, Urea, and Creatinine Acid ISFET Microfluid Sensing Chip".
  16. Guided classmate Wang Shihao to participate in the 9th Formosa Plastics Related Enterprise Application Technology Seminar, and won the school group merit award for "New enzyme immobilization technology applied to EIS microfluidic blood glucose sensing chip".