解剖學科

徐淑媛(Shu-Yuan Hsu)

職稱：副教授

研究室名稱：細胞生物學實驗室

最高學歷：Ph.D.

學校/國家：長庚大學生物醫學研究所/台灣

分機號碼：5088

電子郵件帳號： hsusy@mail.cgu.edu.tw

個人網頁網址：

研究室現有： 博士後研究員   人

博士班研究生    人

碩士班研究生 人

專任研究助理    人

大學部專題生     人

研究方向及研究室特色：

利用基因工程的方式來研究特定基因在活體內的功能，是現今研究的一個重要工具。然而，除了在生化及生理上的改變之外，目前更重要的趨勢是將其功能與臨床上的病症相結合，以期達到促進健康的終極目標。因此我們利用操縱小鼠基因，觀察其對特定疾病過程產生的影響。除了瞭解特定生理生化上的功能影響之外，我們更著重於觀察因基因改變造成之受損組織或器官所產生的形態上改變。將組織或器官切片，以各種不同方式觀察其型態與特定分子的改變，以期與臨床上的特定病理狀態作結合。

(1)               Effect of Pnn on the regulation of alternative splicing in brain

(2)               Protective effects of conditioned medium on myocardial infarction

(3)               Regulation of genes on the proliferation and migration of cancer cells

最近五年所發表論文：

1. Kang-Shuo Chang, Syue-Ting Chen, Shu-Yuan Hsu, Hsin-Ching Sung, Wei-Yin Lin, Ke-Hung Tsui , Yu-Hsiang Lin, Chen-Pang Hou and Horng-Heng Juang. Antioxidant Role by Inducing HO-1 Expression, Is C-X-C Motif Chemokine Receptor 2-Dependent in Human Prostate Stroma and Cancer Cells. Antioxidants 2024, 13:1489

2. Syue‐Ting Chen, Kang‐Shuo Chang, Yu‐Hsiang Lin, Chen‐Pang Hou, Wei‐Yin Lin, Shu‐Yuan Hsu, Hsin‐Ching Sung, Tsui‐Hsia Feng, Ke‐Hung Tsui, Horng‐Heng Juang. Glucose Upregulates ChREBP via Phosphorylation of AKT and AMPK to Modulate MALT1 and WISP1 Expression. Journal of Cellular Physiology 2024, 10:1

3. Syue-Ting Chen, Kang-Shuo Chang, Wei-Yin Lin, Shu-Yuan Hsu, Hsin-Ching Sung, Yu-Hsiang Lin, Tsui-Hsia Feng, Chen-Pang Hou, Horng-Heng Juan. Activating transcription factor 3 is an antitumor gene synergizing with growth differentiation factor 15 to modulate cell growth in human bladder cancer. Biomedical Journal 2024, 6:100756

4. Chin-Chuan Chang, Chih-Hung Chen, Shu-Yuan Hsu, Steve Leu. Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction. BMC Cardiovascular Disorders 2024, 24(1):287

5. Kang-Shuo Chang, Syue-Ting Chen, Hsin-Ching Sung, Shu-Yuan Hsu, Wei-Yin Lin, Chen-Pang Hou, Yu-Hsiang Lin, Tsui-Hsia Feng, Ke-Hung Tsui, Horng-Heng Juang. Androgen Receptor Upregulates Mucosa-Associated Lymphoid Tissue 1 to Induce NF-κB Activity via Androgen-Dependent and-Independent Pathways in Prostate Carcinoma Cells. International journal of molecular sciences 2023, 24(7):6245

6. Chen-Pang Hou, Ke-Hung Tsui, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang. Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15. Biomedical journal 2022, 45(5):763

7. Hsin-Ching Sung, Kang-Shuo Chang, Syue-Ting Chen, Shu-Yuan Hsu, Yu-Hsiang Lin, Chen-Pang Hou, Tsui-Hsia Feng, Ke-Hung Tsui *, Horng-Heng Juang. Metallothionein 2A with Characteristics of Antioxidant and Antitumor is Upregulated by Caffeic Acid Phenethyl Ester in Human Bladder Carcinoma Cells. Antioxidants, 2022, 11, 1509

8. Kang-Shuo Chang, Ke-Hung Tsui, Shu-Yuan Hsu, Hsin-Ching Sung, Yu-Hsiang Lin, Chen-Pang Hou, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang. The Antitumor Effect of Caffeic Acid Phenethyl Ester by Downregulating Mucosa-Associated Lymphoid Tissue 1 via AR/p53/NF-κB Signaling in Prostate Carcinoma Cells. Cancers, 2022, 14, 274

9. Chen-Pang Hou, Ke-Hung Tsui, Syue-Ting Chen, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Tsui-Hsia Feng, Horng-Heng Juang. The Upregulation of Caffeic Acid Phenethyl Ester on Growth Differentiation Factor 15 Inhibits Transforming Growth Factor β/Smad Signaling in Bladder Carcinoma Cells. Biomedicines, 2022, 10, 1625

10. Shu-Yuan Hsu, Chih-Hung Chen, Sujira Mukda, Steve Leu. Neuronal Pnn Deficiency Increases Oxidative Stress and Exacerbates Cerebral Ischemia/Reperfusion Injury in Mice. Antioxidants, 2022, 11, 466

11. Chen-Pang Hou, Ke-Hung Tsui, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang. Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15. Biomedical Journal, 2021, October 15

12. Sheng-Jia Lin, Yin-Cheng Huang, Hao-Yuan Chen, Jia-You Fang, Shu-Yuan Hsu, Hung-Yu Shih, Yu-Chien Liu, Yi-Chuan Cheng. RGS2 Suppresses Melanoma Growth via Inhibiting MAPK and AKT Signaling Pathways. Anticancer Research, 2021, 41, 6135-6145

13. Ke-Hung Tsui, Kang-Shuo Chang, Hsin-Ching Sung, Shu-Yuan Hsu, Yu-Hsiang Lin, Chen-Pang Hou, Pei-Shan Yang, Chien-Lun Chen, Tsui-Hsia Feng, Horng-Heng Juang. Mucosa-Associated Lymphoid Tissue 1 Is an Oncogene Inducing Cell Proliferation, Invasion, and Tumor Growth via the Upregulation of NF-κB Activity in Human Prostate Carcinoma Cells. Biomedicines, 2021, 9, 250-265

14. SY Hsu, S Mukda, S Leu. Expression and Distribution Pattern of Pnn in Ischemic Cerebral Cortex and Cultured Neural Cells Exposed to Oxygen-Glucose Deprivation. Brain Sciences, 2020, 10 (10), 708

15. KC Chiang, KS Chang, SY Hsu, HC Sung, TH Feng, M Chao, HH Juang. Human Heme Oxygenase-1 Induced by Interleukin-6 via JAK/STAT3 Pathways Is a Tumor Suppressor Gene in Hepatoma Cells. Antioxidants, 2020, 9 (3), 251

16. Chen, C.-H.*; Hsu, S.-Y.*; Chiu, C.-C.; Leu, S. MicroRNA-21 Mediates the Protective Effect of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial Infarction in Rats. Cells 2019, 8, 935

17. S Leu, SY Hsu, P Ouyang. 4260 Loss of Pnn in cardiomyocytes results in impairment of intercalated discs and arrhythmogenic cardiomyopathy in mice. European Heart Journal, 2019, 40 (Supplement_1), ehz745. 0138