解剖學科

       陳家嬅 (Chia-Hua Chen)

職稱：助理教授

研究室名稱：腦瘤與多體學研究室

最高學歷：Ph.D.

學校/國家：台灣大學/台灣

分機號碼：+886-3-2118800 ext: 5076

電子郵件帳號：chchen@cgu.edu.tw

個人網頁網址：

研究室現有： 博士後研究員  人

博士班研究生  人

碩士班研究生  人

專任研究助理  人

大學部專題生  人

研究興趣

Oncology; Glioma; Translational medicine; Bioinformatics; Single cell RNA-seq analysis

利用癌症轉錄組結合臨床資訊探索腫瘤進展的分子機制和轉化醫學。

正在進行的計畫和未來的工作

l   神經膠質瘤相關巨噬細胞/小膠質細胞特異性訊號路徑的作用及其在腫瘤進展中的作用

l   腫瘤微環境和腫瘤細胞的相互作用對患者生存和治療標靶的選擇

l   透過分析患者玻片上的目標蛋白進行免疫組織化學染色之結果來預測患者的生存情況

最近五年所發表論文：

1.     Ian Yi-Feng Chang, Hong-Chieh Tsai, Chia-Hua Chen, Hsiu-Chi Chen, Chia-Wen Huang, Gerald F. Cox, Fang-Min Huang, You-Yu Lin, Ko-Ting Chen, Ya-Jui Lin, Kuo-Chen Wei. (2024, Aug). CAN008 prolongs overall survival in patients with newly diagnosed GBM characterized by high tumor mutational burden. Biomedical Journal, 47(4):100660. (SCI, 70/285(Q1), BIOCHEMISTRY & MOLECULAR BIOLOGY).

2.     Hung-Rong Yen, Wen-Chieh Liao, Chia-Hua Chen, Ying-Ai Su, Ying-Wei Huang, Chi Hsiao, Yu-Lun Chou, Yin-Hung Chu, Pin-Keng Shih, Chiung-Hui Liu (2024, May). Targeting chondroitin sulfate suppresses macropinocytosis of breast cancer cells by modulating syndecan-1 expression. Molecular Oncology.

3.     You-Cheng Lin*, Yin-Hung Chu*, Wen-Chieh Liao*, Chia-Hua Chen, Wen-Chuan Hsiao, Ying-Jui Ho, Meng-Yin Yang, and Chiung-Hui Liu (2023, Jul). CHST11-modified chondroitin 4-sulfate as a potential therapeutic target for glioblastoma. American Journal of Cancer Research, 13(7), 2998-3012. (SCI, 70/241(Q2), ONCOLOGY).

4.     Chia-Hua Chen, Kuo-Chen Wei, Wei-Chao Liao, You-Yu Lin, Hsiu-Chi Chen, Li-Ying Feng, Chiung-Hui Liu, Chiung-Yin Huang, Ko-Ting Chen, Chi-Sheng Wu, Yu-Sun Chang, Jau-Song Yu, Ian Yi-Feng Chang. (2022, Sep). Prognostic value of an APOBEC3 deletion polymorphism for glioma patients in Taiwan. Journal of Neurosurgery, 138(5),1325-1337. (SCI, 29/212, Surgery). 本人為第一作者.

5.     Kuo-Chen Wei, You-Cheng Lin, Chia-Hua Chen, Yin-Hung Chu, Chiung-Yin Huang, Wen-Chieh Liao, Chiung-Hui Liu. (2021, Nov). Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells. American Journal of Cancer Research, 11(11), 5472-5484. (SCI, 70/241, oncology).

6.     Chia-Hua Chen, Ya-Jui Lin, You-Yu Lin, Chang-Hung Lin, Li-Ying Feng, Ian Yi-Feng Chang, Kuo-Chen Wei, Chiung-Yin Huang. (2021, Apr). Glioblastoma Primary Cells Retain the Most Copy Number Alterations That Predict Poor Survival in Glioma Patients. Frontiers in Oncology, 11, 621432. (SCI, 85/241, oncology). 本人為第一作者.

7.     Wen-Chieh Liao, Hung-Rong Yen, Chia-Hua Chen, Yin-Hung Chu, Ying-Chyi Song, To-Jung Tseng, Chiung-Hui Liu. (2021, Mar). CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment. American Journal of Cancer Research, 11(3), 812-826. (SCI, 70/241, oncology).

8.     Yu-Ju Wu C, Chen CH, Lin CY, Feng LY, Lin YC, Wei KC, Huang CY, Fang JY, Chen PY. (2020, Feb). CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2. Neuro-oncology, 22(2), 253-266. (SCI, 4/212, clinical neurology).

9.     Chia-Hua Chen, PhD, Pin-Yuan Chen, MD, PhD, You-Yu Lin, PhD, Li-Ying Feng, BS, Shin-Han Chen, MSc, Chia-Yuan Chen, MSc, Yin-Cheng Huang, MD, PhD, Chiung-Yin Huang, PhD, Shih-Ming Jung, MD, Leslie Y. Chen, PhD, and Kuo-Chen Wei, MD (2019, Jan). Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma. Journal of Neurosurgery, 132(1),168-179. (SCI, 14/200, SURGERY; 37/197, CLINICAL NEUROLOGY). MOST 105-2314-B-182-019-MY3. 本人為第一作者.