解剖學科

陳學亭 (Syue-Ting Chen)

職稱：助理教授

研究室名稱：腫瘤細胞生物學實驗室

最高學歷：Ph.D.

學校/國家：國立台灣大學解剖暨細胞生物學研究所

分機號碼：3062

電子郵件帳號：stchen2021@cgu.edu.tw

個人網頁網址：

研究室現有： 博士後研究員   人

博士班研究生    人

碩士班研究生 1人

專任研究助理  1人

大學部專題生 2人

研究方向及研究室特色：

研究興趣領域:

1. 腫瘤細胞生物學

2. 分子訊息傳遞

3. 醣質細胞生物學

   醣基化是常見的蛋白質轉譯後修飾，此種修飾為蛋白質帶來諸多樣貌並賦予了蛋白質更多不同的功能，極大地擴增蛋白質體學的領域及研究困難度。目前已知的蛋白質聚醣結構是透過14種不同的醣基化路徑所產生的，它們包括：氮型醣基化、氧型醣基化(11種)、碳型醣基化及GPI 錨定蛋白的醣基化。迄今為止，至少發現了168種不同的醣基轉移酶負責執行這些醣基化路徑。陸續有研究指出，異常的蛋白質醣基化影響了各種癌症的惡性度，然而對於其中的作用機轉仍知之甚少。我們實驗室致力於探討醣基轉移酶及其作用的蛋白質在癌症中所扮演的角色，為此研究領域貢獻一份心力。

最近五年所發表論文：(列於次頁)

最近五年所發表論文：

1. Chang KS, Chen ST, Hsu SY, Sung HC, Lin WY, Tsui KH, Lin YH, Hou CP, and Juang HH (2024, Dec). The C-X-C Motif Chemokine Ligand 5, Which Exerts an Antioxidant Role by Inducing HO-1 Expression, Is C-X-C Motif Chemokine Receptor 2-Dependent in Human Prostate Stroma and Cancer Cells. Antioxidants, 13(12), 1489.

2. Chang KS, Chen ST, Lin WY, Hsu SY, Sung HC, Lin YH, Feng TH, Hou CP, and Juang HH (2024, Dec). Growth differentiation factor 15 is a glucose-downregulated gene acting as the crosstalk between stroma and cancer cells of the human bladder. American Journal of Physiology-Cell Physiology.

3. Chen ST, Chang KS, Lin YH, Hou CP, Lin WY, Hsu SY, Sung HC, Feng TH, Tsui KH, and Juang HH (2024, Nov). Glucose upregulates ChREBP via phosphorylation of AKT and AMPK to modulate MALT1 and WISP1 expression. Journal of Cellular Physiology.

4. Chen ST, Chang KS, Lin WY, Hsu SY, Sung HC, Lin YH, Feng TH, Hou CP, and Juang HH (2024, Jul). Activating transcription factor 3 is an antitumor gene synergizing with growth differentiation factor 15 to modulate cell growth in human bladder cancer. Biomedical Journal.

5. Lin NY, Lee JJ, Chen ST, Lin JA, Lin CH, Lin HY, Su YH, Chen CC, Lin MC, Kuo CY, and Haung MC (2023, Jul). Truncation of GalNAc-type O-glycans suppresses CD44-mediated osteoclastogenesis and bone metastasis in breast cancer. Molecular Cancer Research, 21 (7): 664–674.

6. Chang KS, Chen ST, Sung HC, Hsu SY, Lin WY, Hou CP, Lin YH, Feng TH, Tsui KH, and Juang HH (2023, Mar). Androgen Receptor Upregulates Mucosa-Associated Lymphoid Tissue 1 to Induce NF-κB Activity via Androgen-Dependent and -Independent Pathways in Prostate Carcinoma Cells. International Journal of Molecular Sciences, 24(7), 6245.

7. Liao YY, Chuang YT, Lin HY, Lin NY, Hsu TW, Hsieh SC, Chen ST, Hung JS, Yang HJ, Liang JT, Huang MC, Huang J (2023, Jan). GALNT2 promotes invasiveness of colorectal cancer cells partly through AXL. Molecular Oncology, 17(1):119-133.

8. Chang KS, Chen ST, Sung HC, Hsu SY, Lin WY, Hou CP, Lin YH, Feng TH, Tsui KH, and Juang HH (2022, Sep). WNT1 Inducible Signaling Pathway Protein 1 Is a Stroma-Specific Secreting Protein Inducing a Fibroblast Contraction and Carcinoma Cell Growth in the Human Prostate. International Journal of Molecular Sciences, 23, 11437.

9. Sung HC, Chang KS, Chen ST, Hsu SY, Lin YH, Hou CP, Feng TH, Tsui KH, and Juang HH (2022, Aug). Metallothionein 2A with Antioxidant and Antitumor Activity Is Upregulated by Caffeic Acid Phenethyl Ester in Human Bladder Carcinoma Cells. Antioxidants, 11(8), 1509.

10. Hou CP, Tsui KH, Chen ST, Chang KS, Sung HC, Hsu SY, Lin YH, Feng TH and Juang HH (2022, Jul). The Upregulation of Caffeic Acid Phenethyl Ester on Growth Differentiation Factor 15 Inhibits Transforming Growth Factor β/Smad Signaling in Bladder Carcinoma Cells . Biomedicines, 10(7), 1625.

11. Lin NY, Chen ST, Chang HL, Lu MY, Yang YL, Chou SW, Lin DT, Lin KH, Jou ST, Hsu WM, Huang MC, and Chang HH (2022, Feb). C1GALT1 expression predicts a favorable prognosis and suppresses malignant phenotypes via TrkA signaling in neuroblastoma. Oncogenesis, 11(1):8.

12. Kuo TC, Wu MH, Yang SH, Chen ST, Hsu TW, Jhuang JY, Liao YY, Tien YW, Huang MC (2021, Feb). C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv. Oncogene, 40(7):1242-1254.

13. Lee PC, Chen ST, Kuo TC, Lin TC, Lin MC, Huang J, Hung JS, Hsu CL, Juan HF, Lee PH, Huang MC (2020, Mar). C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. Oncogene, 39(13):2724-2740.