School of Traditional Chinese Medicine

Research Topics

Recent Research Projects

1. Multifunctional nanocarriers delivered to the kidney via retinol-binding protein 4 (RBP4) for the treatment of kidney injury induced by drug-resistant bacteremia
2. Flexible nano-liposomes containing the multifunctional blueberry-derived active compound pterostilbene for disruption of P. acnes biofilms and enhancement of topical anti-infective activity
3. Lipid nanocarriers conjugated with NIMP-R14 antibody for active targeting of neutrophils to enhance the anti-psoriatic activity of PDE4 inhibitors
4. Nanocarriers with both passive and active targeting capabilities for delivering ciprofloxacin in the treatment of infectious pneumonia: nonionic micelles using IsaB DNA as a ligand
5. Design and synthesis of squalene-containing prodrugs and development of their nanocarriers targeting hair follicles
6. Studies on the anti-inflammatory activity and transdermal absorption of active compounds from Magnolia officinalis
7. Studies on the treatment of atopic dermatitis using Antrodia cinnamomea extracts: anti-inflammatory mechanisms of monophenolic compounds in keratinocytes
8. Establishment of transdermal absorption parameters for a series of synthetic isoflavonoid compounds and investigation of their anti-psoriatic activity
9. Development of optimal separation techniques for polyphenolic compounds from Chinese herbal medicines

Recent Industry-Academia Collaboration Projects

1. Central Taiwan Science Park Bureau: Development of a 505(b)(2) new drug of minocycline for acne vulgaris with a novel dosage form and route of administration
2. Formosa Biomedical Technology Corp.: Studies on transdermal absorption and efficacy of skincare products and beauty devices
3. Ji Huo Li Aesthetics Innovation Research Institute: Transdermal absorption of lactoferrin anti-graying peptides
4. TCI Co., Ltd.: Evaluation of the transdermal absorption capability of LipoMask
5. Standard Chem. & Pharm. Co., Ltd.: Formulation optimization and physicochemical evaluation of VD-T03
6. Shin Fong Pharmaceutical Co., Ltd.: Protein removal testing for rigid contact lenses
7. E Ink Holdings Inc.: Feasibility study on skin permeation capability of a novel transdermal patch platform
8. Key Onco Pharmaceuticals, Inc.: Drug penetration study of KX-01 ointment for psoriasis
9. Enyang Biotechnology: Anti-inflammatory effects of Antrodia cinnamomea extracts for the treatment of psoriasis and atopic dermatitis

Patents

1. Fluorescent Dye Compositions and Uses Thereof
   Jia-Yu Fang, Chih-Jen Wen
   US Patent No.: US9,855,346 B2
   Country: United States
   Patent Term: 2014/11/06–2034/11/06
2. Use of 2,4-Dimethoxy-6-Methylbenzene-1,3-Diol for Treating Atopic Dermatitis
   Dong-Hong Wang, Jia-Yu Fang, Shih-Chun Yang, Tse-Hung Huang
   Taiwan Patent No.: I670055
   Patent Term: 2019/9/1–2038/4/10
3. Use of 2,4-Dimethoxy-6-Methylbenzene-1,3-Diol for Preventing and/or Inhibiting the Growth and Biofilm Formation of Staphylococcus Species
   Dong-Hong Wang, Jia-Yu Fang, Shih-Chun Yang, Tse-Hung Huang
   Taiwan Patent No.: I680756
   Patent Term: 2020/1/1–2038/7/1
4. Use of 2,4-Dimethoxy-6-Methylbenzene-1,3-Diol for Preventing and/or Treating Psoriasis
   Dong-Hong Wang, Jia-Yu Fang, Shih-Chun Yang, Shih-Yi Chuang, Tse-Hung Huang
   Taiwan Patent No.: I716940
   Patent Term: 2021/1/21–2039/7/22
5. Gel-Type Sunscreen Composition
   Chih-Yuan Wu, Shih-Chun Yang, Dong-Hong Wang, Jia-Yu Fang
   Taiwan Patent No.: 1760745
   Patent Term: 20224/11–2040/5/11

Honors and Awards

1. Professor Jia-Yu Fang received the 33rd Wang Min-Ning Award in recognition of achievements in the field of pharmacy.
2. Professor Jia-Yu Fang was again recognized in the 2023 World’s Top 2% Scientists list and ranked 23rd in Taiwan in the field of Clinical Medicine with specialization in pharmacy.
3. Professor Jia-Yu Fang was again included in the 2023 World’s Top 2% Scientists list.
4. Professor Jia-Yu Fang was again recognized in the 2022 World’s Top 2% Scientists list and ranked 23rd in Taiwan in the field of Clinical Medicine with specialization in pharmacy.
5. Professors Jia-Yu Fang and Tsung-Lung Huang were both included in the 2022 World’s Top 2% Scientists lists for both Career-Long Scientific Impact (1960–2021) and Single-Year Scientific Impact (2021).
6. Professors Jia-Yu Fang and Tsung-Lung Huang were both included in the 2021 World’s Top 2% Scientists lists for both Career-Long Scientific Impact (1960–2020) and Single-Year Scientific Impact (2020).

Laboratory Members and Activity Photos

1. Ph.D. Students: 1
2. Master’s Students: 6
3. Full-Time Research Assistants: 8
4. Postdoctoral Researchers: 2

Publications

The selected publications from total 339 articles

*, corresponding author

1. Tsai, M.J., Lin, C.Y., Trousil, J., Sung, C.T., Lee, M.H., Fang, J.Y.*, Yang, S.C. (2023) Proteinase K/retinoic acid-loaded cationic liposomes as multifunctional anti-acne therapy to disorganize biofilm and regulate keratinocyte proliferation. Int. J. Nanomed., 18, 3879‒3896.
2. Yang, S.C., Lin, C.F., Alshetaili, A., Aljuffalin, I.A., Chien, M.Y., Fang, J.Y.* (2023) Dual antibacterial and regenerative activities of platelet-rich plasma combined with β-lactam antibiotics are effective to treat MRSA-infected skin wound: the cell- and animal-based studies. Biomed. Pharmacother., 165, 115017.
3. Huang, T.H., Chen, C.J., Lin, H.C.A., Chen, C.H., Fang, J.Y.* (2023) Self-nanoemulsifying drug delivery system-containing the poorly absorbed drug‒valsartan in post-bariatric surgery. Int. J. Nanomed., 18, 2647‒2658.
4. Lin, C.Y., Yu, H.P., Chang, Y.T., Lin, Z.C., Alalaiwe, A., Hwang, T.L., Fang, J.Y.* (2023) Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via Ly6 antigen for psoriasiform dermatitis alleviation. Biomater. Sci., 11, 873–893.
5. Nirmal, G.R., Lin, Z.C., Lin, C.H., Sung, C.T., Liao, C.C., Fang, J.Y.* (2022) Polydopamine/IR820 nanoparticles as topical phototheranostics for inhibiting psoriasiform lesions through dual photothermal and photodynamic treatments. Biomater. Sci., 10, 6172–6189.
6. Lee, W.R., Chou, W.L., Lin, Z.C., Sung, C.T., Lin, C.Y., Fang, J.Y.* (2022) Laser-assisted nanocarrier delivery to achieve cutaneous siRNA targeting for attenuating psoriasiform dermatitis. J. Control. Release, 347, 590–606.
7. Tseng, C.H., Lin, C.F., Aljuffali, I.A., Huang, J.R., Yang, S.H., Fang, J.Y.* (2022) The effectiveness of synthetic methoxylated isoflavones in delivering to the skin and alleviating psoriasiform lesions via topical absorption. Int. J. Pharm., 617, 121629.
8. Lee, W.R., Hsiao, C.Y., Chang, Z.Y., Wang, P.W., Aljuffali, I.A., Lin, J.Y., Fang, J.Y.* (2022) Cutaneous delivery of cosmeceutical peptides enhanced by picosecond- and nanosecond-domain Nd:YAG lasers with quick recovery of the skin barrier function: comparison with microsecond-domain ablative lasers. Pharmaceutics, 14, 450.
9. Fang, J.Y., Huang, T.H., Chen, W.J., Aljuffali, I.A., Hsu, C.Y. (2022) Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis. Biomed. Pharmacother., 146, 112497.
10. Fang, J.Y., Chou, W.L., Lin, C.F., Sung, C.T., Alalaiwe, A., Yang, S.C. (2021) Facile biofilm penetration of cationic liposomes loaded with DNase I/proteinase K to eradicate Cutibacterium acnes biofilm for treating cutaneous and catheter infections. Int. J. Nanomed., 16, 8121–8138.
11. Chuang, S.Y., Chen, C.Y., Yang, S.C., Alalaiwe, A., Lin, C.H., Fang, J.Y.* (2021) 2,4-Dimethoxy-6-methylbenzene-1,3-diol, a benzenoid from Antrodia cinnamomea, mitigates psoriasiform inflammation by suppressing MAPK/NF-κB phosphorylation and GDAP1L1/Drp1 translocation. Front. Immunol., 12, 664425.
12. Nirmal, G.R., Lin, Z.C., Tsai, M.J., Yang, S.C., Alalaiwe, A., Fang, J.Y.* (2021) Photothermal treatment by PLGA-gold nanorod-isatin nanocomplexes under near-infrared irradiation for alleviating psoriasiform hyperproliferation. J. Control. Release, 333, 487–499.
13. Lin, Z.C., Hwang, T.L., Huang, T.H., Tahara, K., Trousil, J., Fang, J.Y.* (2021) Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation. Theranostics, 11, 4567–4584.
14. Liao, C.C., Yu, H.P., Yang, S.C., Alalaiwe, A., Dai, Y.S., Liu, F.C., Fang, J.Y.* (2021) Multifunctional lipid-based nanocarriers with antibacterial and anti-inflammatory activities for treating MRSA bacteremia in mice. J. Nanobiotechnol., 19, 48.
15. Elzoghby, A.O., Abdelmoneem, M.A., Hassanin, I.A., Abd Elwakil, M.M., Elnaggar, M.A., Mokhtar, S., Fang, J.Y., Elkhodairy, K.A. (2020) Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier and targeting ligand. Biomaterials, 263, 120355.
16. Tang, K.W., Lin, Z.C., Wang, P.W., Alalaiwe, A., Tseng, C.H., Fang, J.Y.* (2020) Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF-κB/AP-1 phosphorylation in keratinocytes. J. Dermatol. Sci., 99, 90–99.
17. Alalaiwe, A., Lin, Y.K., Lin, C.H., Wang, P.W., Lin, J.Y., Fang, J.Y.* (2020) The absorption of polycyclic aromatic hydrocarbons into the skin to elicit cutaneous inflammation: the establishment of structure–permeation and in silico–in vitro–in vivo relationships. Chemosphere, 255, 126955.
18. Yu, H.P., Liu, F.C., Lin, C.Y., Umoro, A., Trousil, J., Hwang, T.L., Fang, J.Y.* (2020) Suppression of neutrophilic inflammation can be modulated by the droplet size of anti-inflammatory nanoemulsions. Nanomedicine, 15, 773–791.
19. Wu, C.Y.J., Chen, C.H., Lin, C.Y., Feng, L.Y., Lin, Y.C., Wei, K.C., Huang, C.Y., Fang, J.Y.*, Chen, P.Y. (2020) CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase-2. Neuro-Oncology, 22, 253–266.
20. Yu, H.P., Liu, F.C., Umoro, A., Lin, Z.C., Elzoghby, A.O., Hwang, T.L., Fang, J.Y.* (2020) Oleic acid-based nanosystems for mitigating acute respiratory distress syndrome in mice through neutrophil suppression: how the particulate size affects therapeutic efficiency. J. Nanobiotechnol., 18, 25.
21. Lee, W.R., Lin, Y.K., Alalaiwe, A., Wang, P.W., Liu, P.Y., Fang, J.Y.* (2020) Fractional laser-mediated siRNA delivery for mitigating psoriasis-like lesions via IL-6 silencing. Mol. Ther.-Nucl. Acids, 19, 240–251.
22. Chen, P.Y., Wu, C.Y.J., Fang, J.H., Chen, H.C., Feng, L.Y., Huang, C.Y., Wei, K.C., Fang, J.Y.*, Lin, C.Y. (2019) Functionl change of effector tumor-infiltrating CCR5+CD38+HLA-DR+CD8+ T cells in glioma microenvironment. Front. Immunol., 10, 2395.
23. Weng, J.R., Huang, T.H., Lin, Z.C., Alalaiwe, A., Fang, J.Y.* (2019) Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-κB/AP-1 activation. Biomed. Pharmacother., 119, 109398.
24. Hsiao, C.Y., Yang, S.C., Alalaiwe, A., Fang, J.Y.* (2019) Laser ablation and topical drug delivery: a review of recent advances. Expert Opin. Drug Deliv., 16, 937–952.
25. Lin, C.Y., Hsu, C.Y., Elzoghby, A.O., Alalaiwe, A., Hwang, T.L., Fang, J.Y.* (2019) Oleic acid as the active agent and lipid matrix in cilomilast-loaded nanocarriers to assist PDE4 inhibition of activated neutrophils for mitigating psoriasis-like lesions. Acta Biomater., 90, 350–361.
26. Fang, J.Y., Lin, C.H., Huang, T.H., Chuang, S.Y. (2019) In vivo rodent models of type 2 diabetes and their usefulness for evaluating flavonoid bioactivity. Nutrients, 11, 530.
27. Lin, Z.C., Hsieh, P.W., Hwang, T.L., Chen, C.Y., Sung, C.T., Fang, J.Y.* (2018) Topical application of anthranilate derivatives ameliorates psoriatic inflammation in a mouse model by inhibiting keratinocyte-derived chemokine expression and neutrophil infiltration. FASEB J., 32, 6783–6795.
28. Abdelmoneem, M.A., Mahmoud, M., Zaky, A., Helmy, M.W., Sallam, M., Fang, J.Y.*, Elkhodairy, K.A., Elzoghby, A.O. (2018) Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma. J. Control. Release, 287, 78–93.
29. Elgohary, M.M., Helmy, M.W., Abdelfattah, E.Z.A., Ragab, D.M., Mortada, S.M., Fang, J.Y.*, Elzoghby, A.O. (2018) Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy. J. Control. Release, 285, 230–243.
30. Chuang, S.Y., Lin, C.H., Sung, C.T., Fang, J.Y.* (2018) Murine models of psoriasis and their usefulness for drug discovery. Expert Opin. Drug Discov., 13, 551–562.
31. Liu, F.C., Yu, H.P., Lin, C.Y., Elzoghby, A.O., Hwang, T.L., Fang, J.Y.* (2018) Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge. J. Nanobiotechnol., 16, 35.
32. Hsu, C.Y., Sung, C.T., Aljuffali, I.A., Chen, C.H., Hu, K.Y., Fang, J.Y.* (2018) Intravenous anti-MRSA phosphatiosomes mediate enhanced affinity to pulmonary surfactants for effective treatment of infectious pneumonia. Nanomed.-Nanotechnol. Biol. Med., 14, 215-225.
33. Liu, K.S., Huang, T.H., Aljuffali, I.A., Chen, E.L., Wang, J.J., Fang, J.Y.* (2017) Exploring the structure-permeation relationship of topical tricyclic antidepressants used for skin analgesia. Int. J. Pharm., 523, 386–397.
34. Hsieh, P.W., Hung, C.F., Lin, C.H., Huang, C.W., Fang, J.Y.* (2017) Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation. Eur. J. Pharm. Biopharm., 114, 154–163.