School of Traditional Chinese Medicine

Research Topics

1. New Drug Development, including serine protease/cathepsin inhibitors, as well as antiviral and anticancer agents
2. Synthesis and Biological Activity Evaluation of Natural Products and Their Analogues
3. Drug Repurposing of Traditional Chinese Medicines

Laboratory Members and Activity Photos

Publications

*, corresponding author

1. Amos C. Hung, Chun-Hao Tsai, Ming-Feng Hou, Wen-Lin Chang, Chie-Hong Wang, Yi-Chen Lee, Alice Ko, Stephen Chu-Sung Hu, Fang-Rong Chang, Pei-Wen Hsieh*, Shyng-Shiou F. Yuan*. The synthetic β-nitrostyrene derivative CYT-rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway. Cancer Lett. 2016, 371:251-261. (SCI) (I.F.: 6.508; R/C=29/229 in ONCOLOGY)
2. Jin-Yuan Ho, Jyh-Haur Chern, Chung-Fan Hsieh, Szu-Ting Liu, Chien-Jou Liu, Ya-Sian Wang, Ta-Wei Kuo, Sheng-Ju Hsu, Ten-Kuang Yeh, Shin-Ru Shih, Pei-Wen Hsieh, Chen-Hsun Chiu, Jim-Tong Horng. In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71. J. Antimicrob. Chemother. 2016, 71:1922-1932. (SCI) (I.F.: 4.715; R/C=27/267 in PHARMACOLOGY & PHARMACY)
3. Chien-Chong Hong, Chih-Chung Lin, Chian-Lang Hong, Zi-Xiang Lin, Meng-Hua Chung, Pei-Wen Hsieh. Analyzer with On-Chip molecularly-imprinted biosensors for electrical detection of propofol in plasma samples. Biosens. Bioelectron. 2016, 86:623-629. (SCI) (I.F.: 9.518; R/C=1/84 in CHEMISTRY, ANALYTICAL)
4. Yu-Li Chen, Tsong-Long Hwang, Huang-Ping Yu, Jia-You Fang, Kowit Yu Chong, Yao-Wen Chang, Chun-Yu Chen, Hsuan-Wu Yang, Wen-Yi Chang, Pei-Wen Hsieh*. Ilex kaushue and its bioactive component 3,5-dicaffeoylquinic acid protected mice from lipopolysaccharide-induced acute lung injury. Sci. Rep. 2016, 6:34243. (SCI) (I.F.: 4.011; R/C=15/69 in MULTIDISCIPLINARY SCIENCES)
5. Chung-Fan Hsieh, Yu-Li Chen, Chwan-Fwu Lin, Jin-Yuan Ho, Chun-Hsun Huang, Cheng-Hsun Chiu, Pei-Wen Hsieh, Jim-Tong Horng. An extract from Taxodium distichum targets hemagglutinin- and neuraminidase-related activities of influenza virus in vitro. Sci. Rep. 2016, 6:36015. (SCI) (I.F.: 4.011; R/C=15/69 in MULTIDISCIPLINARY SCIENCES)
6. Wen-Chin Chiu, Yi-Chen Lee, Yu-Han Su, Yen-Yun Wang, Chun-Hao Tsai, Yi-An Hou, Chie-Hong Wang, Ying-Fong Huang, Chih-Jen Huang, Shah-Hwa Chou, Pei-Wen Hsieh, Shyng-Shiou F. Yuan. The synthetic β-nitrostyrene derivative CYT-Rx20 inhibits esophageal tumor growth and metastasis via PI3K/AKT and STAT3 pathways. PLoS One 2016, 11:e0166453. (SCI) (I.F.: 2.776; R/C=24/69 in MULTIDISCIPLINARY SCIENCES)
7. Chun-Hao Tsai, Pei-Wen Hsieh, Yi-Chen Lee, Chie-Hong Wang, Wen-Chin Chiu, Chun-Wun Lu, Yen-Yun Wang, Stephen Chu-Sung Hu, Tain-Lu Cheng, Shyng-Shiou F. Yuan*. 3'-Hydroxy-4'-methoxy-β-methyl-β-nitrostyrene inhibits tumor growth through ROS generation and GSH depletion in lung cancer cells. Life Sci. 2017, 172:19-26. (SCI) (I.F.: 3.448; R/C= 76/267 in PHARMACOLOGY & PHARMACY)
8. Shun-Chin Yang, Shih-Hsin Chang, Pei-Wen Hsieh, Yin-Ting Huang, Chiu-Ming Ho, Yung-Fong Tsai, Tsong-Long Hwang. Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1. Free Rad. Bio. Med. 2017, 106:254-269. (SCI). (I.F.: 5.657; R/C=43/298 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
9. Chun-Hao Tsai, Amos C. Hung, Yuan-Yin Chen, Ya-Wen Chiu, Pei-Wen Hsieh, Yi-Chen Lee, Yu-Han Su, Po-Chih Chang, Stephen Chu-Sung Hu, Shyng-Shiou F. Yuan*. 3’-Hydroxy-4’-methoxy-β-methyl-β-nitrostyrene inhibits tumor-igenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction. Oncotarget 2017, 8:18106-18117.
10. Pei-Wen Hsieh, Chi-Feng Hung, Chih-Hung Lin, Chang-Wei Huang, Jia-You Fang. Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation. Eur. J. Pharm. Biopharm. 2017, 114:154-163. (SCI) (I.F.: 4.708; R/C=28/267 in PHARMACOLOGY & PHARMACY)
11. Yen-Yun Wang, Yuk-Kwan Chen, Ya-Ling Hsu, Wen-Chin Chiu, Chun-Hao Tsai, Stephen Chu-Sung Hu, Pei-Wen Hsieh, Shyng-Shiou F. Yuan*. Synthetic β-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction. Head & Neck 2017, 39:1055-1064. (SCI) (I.F.: 2.442; R/C=10/42 in OTORHINOLARYNGOLOGY)
12. Yen-Yun Wang, Yuk-Kwan Chen, Stephen Chu-Sung Hu, Ya-Ling Hsu, Chun-Hao Tsai, Tsung-Chen Chi, Wan-Ling Huang, Pei-Wen Hsieh, Shyng-Shiou F. Yuan. CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis. Cancer Chemother. Pharmacol. 2017, 79:1129-1140. (SCI) (I.F.: 3.008; R/C=101/267 in PHARMACOLOGY & PHARMACY)
13. Po-Hsiung Kung, Pei-Wen Hsieh, Ying-Ting Lin, Jia-Hua Lee, I-Hua Chen, Chin-Chung Wu. HPW-RX40 Prevents Human Platelet Activation by Attenuating Cell Surface Protein Disulfide Isomerases. Redo. Biol. 2017, 13:266-277. (SCI) (I.F.: 7.793; R/C=28/298 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
14. Yen-Yun Wang, Pei-Wen Hsieh, Yuk-Kwan Chen, Stephen Chu-Sung Hu, Ya-Ling Hsu, Chun-Hao Tsai, Shyng-Shiou F Yuan. CYT-Rx20 inhibits cervical cancer cell growth and migration through oxidative stress-induced DNA damage, cell apoptosis, and epithelial-to-mesenchymal transition inhibition. Int. J. Gynecol. Cancer 2017, 27:1306-1317. (SCI) (I.F.: 1.764; R/C=52/83 in OBSTETRICS & GYNECOLOGY)
15. Yu-Li Chen, Tsong-Long Hwang, Jia-You Fang, Yu-Hsuan Lan, Kowit Yu Chong, Pei-Wen Hsieh*. Polysaccharides from Kochia scoparia fruits protect mice from lipopolysaccharide-mediated acute lung injury by inhibiting neutrophil elastase. J. Funct. Foods. 2017, 38:582-590. (SCI) (I.F.: 3.197; R/C=33/135 in FOOD SCIENCE & TECHNOLOGY)
16. Yao-Wen Chang, Ching-Ping Tseng, Chih-Hsun Lee, Tsong-Long Hwang, Yu-Li Chen, Mei-Tzu Su, Kowit-Yu Chong, Ying-Wei Lan, Chin-Chung Wu, Kung-Ju Chen, Fen-Hua Lu, Hsiang-Ruei Liao, Chuen Hsueh, Pei-Wen Hsieh*. β-Nitrostyrene derivatives attenuate LPS-mediated acute lung injury via the inhibition of neutrophil-platelet interactions and NET release. Am. J. Physiol. Lung Cell Mol. Physiol. 2018, 314:L654-L669. (SCI) (I.F.: 4.060; R/C=14/81 in PHYSIOLOGY)
17. Bidyadhar Sethy, Chung-Fan Hsieh, Chieh Yeh, Jim-Tong Horng, Pei-Wen Hsieh*. Design, synthesis and structure-activity relationships of a new class of anti-human enterovirus D68 and A71 agents. Future Med. Chem. 2018, 10:1333-1347. (SCI) (I.F.: 3.617; R/C=19/61 in CHEMISTRY, MEDICINAL)
18. 86.   Zih-Chan Lin, Pei-Wen Hsieh, Tsong-Long Hwang, Chi-Yuan Chen, Calvin T. Sung, Jia-You Fang. Topical application of anthranilate derivatives ameliorates psoriatic inflammation in a mouse model by inhibiting keratinocyte-derived chemokine expression and neutrophil infiltration. FASEB J. 2018, 32:6783-6795. (SCI) (I.F.: 5.391; R/C=8/87 in Biology)
19. Bidyadhar Sethy, Chung-Fan Hsieh, Ta-Jen Lin, Po-Yuan Hu, Yu-Li Chen, Chia-Yi Lin, Sung-Nain Tseng, Jim-Tong Horng*, Pei-Wen Hsieh*. Design, synthesis, and biological evaluation of itaconic acid derivatives as potential anti-influenza agents. J. Med. Chem. 2019, 62:2390-2403. (SCI) (I.F.: 6.054; R/C=3/61 in CHEMISTRY, MEDICINAL)
20. Nobuo Watanabe, Masako Kidokoro, Yusuke Suzuki, Makiko Tanaka, Shigeaki Inoue, Hideo Tsukamoto, Noriaki Hirayama, Pei-Wen Hsieh, Ching-Ping Tseng, Yoshihide Nakagawa, Sadaki Inokuchi. A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction. PLoS One 2019, 14: e0222331. (SCI) (I.F.: 2.776; R/C=24/69 in MULTIDISCIPLINARY SCIENCES)
21. Ching-Ping Tseng, Yu-Ling Huang, Yao-Wen Chang, Hsiang-Ruei Liao, Yu-Li Chen, Pei-Wen Hsieh*. Polysaccharide-containing fraction from Artemisia argyi inhibits tumor cell-induced platelet aggregation by blocking interaction of podoplanin with C-type lectin-like receptor 2. J. Food Drug Anal. 2019, 28:115-123. (SCI) (I.F.: 4.176; R/C=13/135 in FOOD SCIENCE & TECHNOLOGY)
22. Chung-Fan Hsieh, Jia-Rong Jheng, Guan-Hua LinYu-Li Chen, Jin-Yuan Ho, Chien-Jou Liu, Kuei-Yang Hsu, Yuan-Siao Chen, Yoke Fun Chan, Hui-Ming Yu, Pei-Wen Hsieh, Jyh-Haur Chern, Jim-Tong Horng. Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors. Emerg. Microbes Infec. 2020, 9:1194-1205. (SCI) (I.F.: 19.568; 7/136 in Microbiology)
23. Eman Al-Sayed, Michal Korinek, Ahmed Esmat, Guan-Yu Chen, Yuan-Bin Cheng, Pei-Wen Hsieh, Bing-Hung Chen, Tsong-Long Hwang*. Anti-inflammatory, hepatoprotective and antioxidant activity of ellagitannin isolated from Melaleuca styphelioides. Phytochemistry 2020, 177:112429. (SCI) (I.F.: 4.004; 53/238 in PLANT SCIENCES)
24. Kung-Ju Chen, Yu-Li Chen, Shir-Hwa Ueng, Tsong-Long Hwang, Liang-Mou Kuo*, Pei-Wen Hsieh*. Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil–induced intestinal mucositis. Biomed. Pharmacother. 2021, 134:111152. (SCI) (I.F.: 7.419; R/C=24/279 in PHARMACOLOGY & PHARMACY)
25. Michal Korinek, Pei-Shan Hsieh, Yu-Li Chen, Pei-Wen Hsieh, Shih-Hsin Chang, Yi-Hsiu Wu, Tsong-Long Hwang*. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochem. Pharmacol. 2021, 190:114596. (SCI) (I.F.: 6.100; R/C=46/279 in PHARMACOLOGY & PHARMACY)
26. Che-Chuan Wang, Pei-Wen Hsieh, Jinn-Rung Kou, Su-Jane Wang*. Rosmarinic acid, a bioactive phenolic compound, inhibits glutamate release from rat cerebrocortical synaptosomes through GABAA receptor activation. Biomolecules 2021, 11:1029. (SCI) (I.F.: 6.064; R/C=75/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
27. Hao-Wei Chu, Bidyadhar Sethy, Pei-Wen Hsieh, Jim-Tong Horng*. Identification of potential drug targets of broad-spectrum inhibitors with a Michael acceptor moiety using shotgun proteomics. Viruses 2021, 13:1756. (SCI) (I.F.: 5.818; 14/37 in VIROLOGY)
28. Tzu-Yu Lin, Cheng-Wei Lu, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang*. Natural product isoliquiritigenin activates GABAB receptors to decrease voltage-gate Ca2+ channels and glutamate release in rat cerebrocortical nerve terminals. Biomolecules 2021, 11:1537. (SCI) (I.F.: 6.064; R/C=75/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
29. Anna Chang, Chi-Feng Hung, Pei-Wen Hsieh, Horng-Huey Ko and Su-Jane Wang*. Eupafolin suppresses P/Q-Type Ca2+ channels to inhibit Ca2+/ calmodulin-dependent protein kinase II and glutamate release at rat cerebrocortical nerve terminals. Biomol. Ther. (Seoul) 2021, 29:630-636. (SCI) (I.F.: 4.231; R/C=106/279 in PHARMACOLOGY & PHARMACY)
30. Yi-Chieh Hung, Yi-Hsiu Kuo, Pei-Wen Hsieh, Ting-Yang Hsieh, Jinn-Rung Kuo, Su-Jane Wang*. Chlorogenic acid decreases glutamate release from rat cortical nerve terminals by P/Q-type Ca2+ channel suppression: a possible neuroprotective mechanism. Int. J. Mol. Sci. 2021, 22:11447. (SCI) (I.F.: 6.208; R/C=69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
31. Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin*, Su-Jane Wang*. An anthranilate derivative inhibits glutamate release and glutamate excitotoxicity in rats. Int. J. Mol. Sci. 2022, 23:2641. (SCI) (I.F.: 6.208; R/C=69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
32. Chung-Fan Hsieh, Yu-Li Chen, Guan-Hua Lin, Yoke Fun Chan, Pei-Wen Hsieh, and Jim-Tong Horng*. 3,4-Dicaffeoylquinic acid from the medicinal plant Ilex kaushue disrupts the interaction between the five-fold axis of enterovirus A-71 and the heparan sulfate receptor. J. Virol. 2022, 96: e0054221. (SCI) (I.F.: 6.549; 11/37 in VIROLOGY)
33. Kung-Ju Chen, Yu-Ling Huang, Liang-Mou Kuo, Yi-Ting Chen, Chi-Feng Hung, Pei-Wen Hsieh*. Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil–induced intestinal mucositis: impact on inflammation and gut microbiota dysbiosis. Phytomedicine 2022, 101:154092. (SCI) (I.F.: 6.656; R/C=1/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)