107年健康老化研究中心 第一次老化相關疾
報告摘要：
Neurodegenerative diseases research team intends to explore the cellular mechanism of designated ageing diseases or phenotype. In collaboration with NRC of CGMH and molecular imaging team, currently we have 6 ongoing projects conducted in ageing-related topics. The production of PARK14 KI mice (PLA2G6/D331Y) leads to a finding that these pathological progress links with mitochondrial dysfunction and apoptosis in SNpc dopamine neurons. In 6-OHDA-lesioned PD mice treated with L-dopa to induce drug side effect of dyskinesia (LID), we found optogenetic manipulation of cortical Glu neurons (vGluT2-Cre mice) would subside the dyskinesic symptoms with altered pNR2B signal in the striatum. In brain and cultured RBA-1 and SK-N-SH cell lines, we found HO-1/CO offers a cytoprotective role in neural inflammation and degeneration. With the use of 18F-AV-45, 18F-THK-5851 and 18F-florbetapir, brain imaging team members are able to detect pathological protein markers in various neurological and psychiatric disorders in both patients and animal models. With the production of Nptx2 KO mice, the role of this gene product was identified that showed an anxiety phenotype with reduced hippocampal neurogenesis, mediated through the hippocampal CRF signaling. Finally, in a circadian rhythm study, research team identified that SCN oscillator could play as a glucose sensor and, through the activity of KATP channel, regulates the light-dark cycle.