Department of Anatomy

          Chia-Hua Chen

Appointments: Assistant Professor

Lab: Glioma and Multiomics

Education: Ph.D.

School/Nation: National Taiwan University/Taiwan

Tel: +886-3-2118800 ext: 5076

E-mail: chchen@cgu.edu.tw

Research website:

研究室現有： 博士後研究員  人

博士班研究生  人

碩士班研究生  人

專任研究助理    人

大學部專題生  人

Research interest

Oncology; Glioma; Translational medicine; Bioinformatics; Single cell RNA-seq analysis

Using cancer transcriptome combined with clinical information to explore the molecular mechanisms of tumor progression and translational medicine.

Ongoing projects and future works

l   The role of glioma-associated macrophages/microglia-specific signaling pathways and their effects in tumor progression

l   Interaction of tumor microenvironment and tumor cells to patient survival and selection of therapeutic targets

l   Predict patient survival from immunohistochemical staining of targeted protein on patient slides

Publications:

1.      Ian Yi-Feng Chang, Hong-Chieh Tsai, Chia-Hua Chen, Hsiu-Chi Chen, Chia-Wen Huang, Gerald F. Cox, Fang-Min Huang, You-Yu Lin, Ko-Ting Chen, Ya-Jui Lin, Kuo-Chen Wei. (2024, Aug). CAN008 prolongs overall survival in patients with newly diagnosed GBM characterized by high tumor mutational burden. Biomedical Journal, 47(4):100660. (SCI, 70/285(Q1), BIOCHEMISTRY & MOLECULAR BIOLOGY).

2.      Hung-Rong Yen, Wen-Chieh Liao, Chia-Hua Chen, Ying-Ai Su, Ying-Wei Huang, Chi Hsiao, Yu-Lun Chou, Yin-Hung Chu, Pin-Keng Shih, Chiung-Hui Liu (2024, May). Targeting chondroitin sulfate suppresses macropinocytosis of breast cancer cells by modulating syndecan-1 expression. Molecular Oncology.

3.      You-Cheng Lin*, Yin-Hung Chu*, Wen-Chieh Liao*, Chia-Hua Chen, Wen-Chuan Hsiao, Ying-Jui Ho, Meng-Yin Yang, and Chiung-Hui Liu (2023, Jul). CHST11-modified chondroitin 4-sulfate as a potential therapeutic target for glioblastoma. American Journal of Cancer Research, 13(7), 2998-3012. (SCI, 70/241(Q2), ONCOLOGY).

4.      Chia-Hua Chen, Kuo-Chen Wei, Wei-Chao Liao, You-Yu Lin, Hsiu-Chi Chen, Li-Ying Feng, Chiung-Hui Liu, Chiung-Yin Huang, Ko-Ting Chen, Chi-Sheng Wu, Yu-Sun Chang, Jau-Song Yu, Ian Yi-Feng Chang. (2022, Sep). Prognostic value of an APOBEC3 deletion polymorphism for glioma patients in Taiwan. Journal of Neurosurgery, 138(5),1325-1337. (SCI, 29/212, Surgery). 本人為第一作者.

5.      Kuo-Chen Wei, You-Cheng Lin, Chia-Hua Chen, Yin-Hung Chu, Chiung-Yin Huang, Wen-Chieh Liao, Chiung-Hui Liu. (2021, Nov). Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells. American Journal of Cancer Research, 11(11), 5472-5484. (SCI, 70/241, oncology).

6.      Chia-Hua Chen, Ya-Jui Lin, You-Yu Lin, Chang-Hung Lin, Li-Ying Feng, Ian Yi-Feng Chang, Kuo-Chen Wei, Chiung-Yin Huang. (2021, Apr). Glioblastoma Primary Cells Retain the Most Copy Number Alterations That Predict Poor Survival in Glioma Patients. Frontiers in Oncology, 11, 621432. (SCI, 85/241, oncology). 本人為第一作者.

7.      Wen-Chieh Liao, Hung-Rong Yen, Chia-Hua Chen, Yin-Hung Chu, Ying-Chyi Song, To-Jung Tseng, Chiung-Hui Liu. (2021, Mar). CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment. American Journal of Cancer Research, 11(3), 812-826. (SCI, 70/241, oncology).

8.      Yu-Ju Wu C, Chen CH, Lin CY, Feng LY, Lin YC, Wei KC, Huang CY, Fang JY, Chen PY. (2020, Feb). CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2. Neuro-oncology, 22(2), 253-266. (SCI, 4/212, clinical neurology).

9.      Chia-Hua Chen, PhD, Pin-Yuan Chen, MD, PhD, You-Yu Lin, PhD, Li-Ying Feng, BS, Shin-Han Chen, MSc, Chia-Yuan Chen, MSc, Yin-Cheng Huang, MD, PhD, Chiung-Yin Huang, PhD, Shih-Ming Jung, MD, Leslie Y. Chen, PhD, and Kuo-Chen Wei, MD (2019, Jan). Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma. Journal of Neurosurgery, 132(1),168-179. (SCI, 14/200, SURGERY; 37/197, CLINICAL NEUROLOGY). MOST 105-2314-B-182-019-MY3. 本人為第一作者.