Department of Anatomy

Syue-Ting Chen

Appointments：Assistant Professor

Lab：Tumor Cell Biology Lab.

Education：Ph.D.

School/Nation：National Taiwan University, Taiwan

Tel: +886-3-2118800 ext. 3062

E-mail: stchen2021@cgu.edu.tw

Research website:

研究室現有： 博士後研究員   人

博士班研究生    人

碩士班研究生 1人

專任研究助理  1人

大學部專題生 2人

Research outline：(1-3 pages)

Areas of research interest:

1. Tumor cell biology

2. Molecular signal transduction

3. Protein glycosylation in cell biology

Glycosylation of proteins is one of the most common post-translational modification. It creates diverse proteoforms with different functions and greatly amplifies the proteome. The known glycan structures of proteins are generated through 14 different glycosylation pathways, including N-glycosylation, 11 types of O-glycosylation, C-mannosylation and generation of GPI-anchored proteins. To date, there are at least 168 distinct glycosyltransferases were discovered to conduct these protein glycosylation pathways. Plenty of studies elucidated that aberrant expression of these glycosyltransferases was associated with malignancy in many cancers. However, the specific underlying mechanisms of these glycosyltransferases in cancers remain unknown, it is worth investigating its specific role in cancers.

Papers Published in the Last Five Years: (Listed on the next page)

Publications:

1. Chang KS, Chen ST, Hsu SY, Sung HC, Lin WY, Tsui KH, Lin YH, Hou CP, and Juang HH (2024, Dec). The C-X-C Motif Chemokine Ligand 5, Which Exerts an Antioxidant Role by Inducing HO-1 Expression, Is C-X-C Motif Chemokine Receptor 2-Dependent in Human Prostate Stroma and Cancer Cells. Antioxidants, 13(12), 1489.

2. Chang KS, Chen ST, Lin WY, Hsu SY, Sung HC, Lin YH, Feng TH, Hou CP, and Juang HH (2024, Dec). Growth differentiation factor 15 is a glucose-downregulated gene acting as the crosstalk between stroma and cancer cells of the human bladder. American Journal of Physiology-Cell Physiology.

3. Chen ST, Chang KS, Lin YH, Hou CP, Lin WY, Hsu SY, Sung HC, Feng TH, Tsui KH, and Juang HH (2024, Nov). Glucose upregulates ChREBP via phosphorylation of AKT and AMPK to modulate MALT1 and WISP1 expression. Journal of Cellular Physiology.

4. Chen ST, Chang KS, Lin WY, Hsu SY, Sung HC, Lin YH, Feng TH, Hou CP, and Juang HH (2024, Jul). Activating transcription factor 3 is an antitumor gene synergizing with growth differentiation factor 15 to modulate cell growth in human bladder cancer. Biomedical Journal.

5. Lin NY, Lee JJ, Chen ST, Lin JA, Lin CH, Lin HY, Su YH, Chen CC, Lin MC, Kuo CY, and Haung MC (2023, Jul). Truncation of GalNAc-type O-glycans suppresses CD44-mediated osteoclastogenesis and bone metastasis in breast cancer. Molecular Cancer Research, 21 (7): 664–674.

6. Chang KS, Chen ST, Sung HC, Hsu SY, Lin WY, Hou CP, Lin YH, Feng TH, Tsui KH, and Juang HH (2023, Mar). Androgen Receptor Upregulates Mucosa-Associated Lymphoid Tissue 1 to Induce NF-κB Activity via Androgen-Dependent and -Independent Pathways in Prostate Carcinoma Cells. International Journal of Molecular Sciences, 24(7), 6245.

7. Liao YY, Chuang YT, Lin HY, Lin NY, Hsu TW, Hsieh SC, Chen ST, Hung JS, Yang HJ, Liang JT, Huang MC, Huang J (2023, Jan). GALNT2 promotes invasiveness of colorectal cancer cells partly through AXL. Molecular Oncology, 17(1):119-133.

8. Chang KS, Chen ST, Sung HC, Hsu SY, Lin WY, Hou CP, Lin YH, Feng TH, Tsui KH, and Juang HH (2022, Sep). WNT1 Inducible Signaling Pathway Protein 1 Is a Stroma-Specific Secreting Protein Inducing a Fibroblast Contraction and Carcinoma Cell Growth in the Human Prostate. International Journal of Molecular Sciences, 23, 11437.

9. Sung HC, Chang KS, Chen ST, Hsu SY, Lin YH, Hou CP, Feng TH, Tsui KH, and Juang HH (2022, Aug). Metallothionein 2A with Antioxidant and Antitumor Activity Is Upregulated by Caffeic Acid Phenethyl Ester in Human Bladder Carcinoma Cells. Antioxidants, 11(8), 1509.

10. Hou CP, Tsui KH, Chen ST, Chang KS, Sung HC, Hsu SY, Lin YH, Feng TH and Juang HH (2022, Jul). The Upregulation of Caffeic Acid Phenethyl Ester on Growth Differentiation Factor 15 Inhibits Transforming Growth Factor β/Smad Signaling in Bladder Carcinoma Cells . Biomedicines, 10(7), 1625.

11. Lin NY, Chen ST, Chang HL, Lu MY, Yang YL, Chou SW, Lin DT, Lin KH, Jou ST, Hsu WM, Huang MC, and Chang HH (2022, Feb). C1GALT1 expression predicts a favorable prognosis and suppresses malignant phenotypes via TrkA signaling in neuroblastoma. Oncogenesis, 11(1):8.

12. Kuo TC, Wu MH, Yang SH, Chen ST, Hsu TW, Jhuang JY, Liao YY, Tien YW, Huang MC (2021, Feb). C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin αv. Oncogene, 40(7):1242-1254.

13. Lee PC, Chen ST, Kuo TC, Lin TC, Lin MC, Huang J, Hung JS, Hsu CL, Juan HF, Lee PH, Huang MC (2020, Mar). C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. Oncogene, 39(13):2724-2740.